Fergus O'Farrell (@fergusofarrell) header
Fergus O'Farrell (@fergusofarrell) profile picture

Fergus O'Farrell

@fergusofarrell

Doctor (Neuropathology SpR) & Neuroscience postdoc. PhD via @UCL_MBPhD. Neuron-glial-vascular interactions, physiology. 🌿📚🏳️‍🌈 he/him

 London
linktr.ee/ofarf
Joined December 2008
  • Tweets4.7K
  • Following4.2K
  • Followers1.9K
Brain capillary in an acute cortical slice. Imaged by me 6 years ago today (according to my phone).
Image from Fergus O'Farrell (@fergusofarrell)
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Gobbling up @StevenIsserlis' "The Marquis de Corberon Cello" 300th anniversary collection. Currently the Dvořák B minor concerto: goosebumps. Please listen!
Image from Fergus O'Farrell (@fergusofarrell)
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Histological aging signatures for monitoring tissue-specific aging and disease nature.com/articles/s41591-0…
Histological aging signatures for monitoring tissue-specific aging and disease

Histological aging signatures for monitoring tissue-specific aging and disease

Nature Medicine - Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to...

nature.com
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AHA Science (@AHAScience) profile picture
AHA Science
@AHAScienceMay 26
Published today, Vascular Contributions to Cognitive Impairment (VCID) and Brain Health: Clinical Update and Mechanistic Considerations. This paper proposes that multi-mechanistic origins of VCID and time-appropriate interventions that complement VRFs modification are important to maintaining brain health and preserving cognitive function across the lifespan. 📷 Conceptual diagram of vascular contributions to age-related cognitive decline and worsening brain health.
Image from AHA Science (@AHAScience)
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Neurodegenerative diseases need more mechanism-informed trials nature.com/articles/s41591-0…
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The source, because no one bothers these days...: Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins science.org/doi/10.1126/scie…
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

A model of the “average” synapse shows ~300,000 proteins and all organelles in the correct copy numbers, sizes, and positions.

science.org
Andrew Côté (@Andercot) profile pictureAndrew Côté
@AndercotFeb 19
A realistic picture of how closely packed molecules are inside a synapse of a nerve cell.
Image from Andrew Côté (@Andercot)
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GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection nature.com/articles/s41467-0…
GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling...

GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling...

Nature Communications - After a heart attack, blood flow restoration often fails in small vessels, worsening outcome. Here, the authors show that remote ischaemic preconditioning releases the gut...

nature.com
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Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence: Cancer Cell cell.com/cancer-cell/fulltex…
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Brain (@Brain1878) profile picture
Brain@Brain187829 Nov 2025
Jean-Martin Charcot was born in Paris on 29 November 1825. @ajlees marks the bicentenary of Charcot's birth by reflecting on how his scientific legacy continues to shape neurology today. tinyurl.com/s3c8rhhm
Image from Brain (@Brain1878)
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Simon Mead (@smead2) profile picture
Simon Mead@smead212 Nov 2025
Papers like this which demonstrate that alpha synuclein can act potently as prions, are exactly why you need to have proportionate safety measures in labs doing this kind of work. If you work on this and don’t have safety measures ask why! Great paper btw. nature.com/articles/s41586-0…
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Lymphoid gene expression supports neuroprotective microglia function nature.com/articles/s41586-0…
Lymphoid gene expression supports neuroprotective microglia function

Lymphoid gene expression supports neuroprotective microglia function

Nature - PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating...

nature.com
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Fergus O'Farrell retweeted
nature (@Nature) profile picture
nature
@Nature7 Nov 2025
Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT go.nature.com/4qPa53C
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John Lukens (@LukensJohnR) profile picture
John Lukens
@LukensJohnR6 Nov 2025
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease @NatureNeuro nature.com/articles/s41593-0…
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease

Nature Neuroscience - Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to...

nature.com
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Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human nature.com/articles/s41467-0…
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Rong Fan (@RongFan8) profile picture
Rong Fan@RongFan85 Nov 2025
Thrilled see our paper out in @Nature ! 🤩 Wonderful collaboration with @GoCasteloBranco. Kudos to my amazing postdoc @Di_0579 at @YaleEngineering and Leslie Kirby from Goncalo's lab @karolinskainst. Huge team science with @YaleMed @UCSF @ASTARsg nature.com/articles/s41586-0…
Spatial dynamics of brain development and neuroinflammation

Spatial dynamics of brain development and neuroinflammation

Nature - A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

nature.com
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Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L9…
Image from Joseph G. Gleeson (@jogleeson_ucsd)
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Neuron (@NeuroCellPress) profile picture
Neuron@NeuroCellPress30 Oct 2025
Online now: The brain neurovascular epigenome and its association with dementia dlvr.it/TNzKxX
The brain neurovascular epigenome and its association with dementia

The brain neurovascular epigenome and its association with dementia

Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and...

cell.com
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The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease go.nature.com/47NI2Ke
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Earl K. Miller (@MillerLabMIT) profile picture
Earl K. Miller@MillerLabMIT29 Oct 2025
Today, I teach the (graduate) kids about long-term memory. I'm bringing along my 3D print of HM's brain, made from post-mortem histology. #neuroscience
Image from Earl K. Miller (@MillerLabMIT)
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The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation | Science Advances science.org/doi/10.1126/scia…
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and...

The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and...

CLIC1 regulates surveillance, morphology, and interleukin release in mouse and human brain microglia.

science.org
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Excited to share our @CurrentBiology Primer written with @AudreyChagnot in the Brain-Body Interactions special issue! We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health. @UKDRI @TheBHF shorturl.at/NNc57
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