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Emily Derrick

@emsderrick

PhD student | Immunotherapies | CRISPR šŸ§¬ @PeterMacCC

 Melbourne, Victoria
Joined June 2018
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Photo by Emily Derrick (@emsderrick)
Excited to finally see this work come out online @NaturePortfolio. In this work we identify FOXO1 overexpression as a strategy to improve CAR T cell persistence and metabolic function using CAR T derived from mice, healthy donors and cancer patients. nature.com/articles/s41586-0ā€¦
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Nature - Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

nature.com
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Excited to share the latest work from the lab led by @ImranHouse and @emsderrick. Using CRISPR HDR we report a method to generate bona fide reporters for a secreted factor of interest, in our case CXCL9. cell.com/cell-reports/fullteā€¦
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9...

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9...

House, Derrick, etĀ al. develop a reporter cell line through CRISPR-Cas9-mediated ā€œknockinā€ of GFP cDNA immediately prior to the Cxcl9 stop codon. This enables a CRISPR-Cas9 screen for regulators of...

cell.com
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