Statistical Geneticist at @KorroBio
Cambridge, MA
Joined September 2011
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An exciting day for @KorroBio!
We are excited to announce we have closed our merger with @frequencytx and private placement of $117M. The combined company is expected to publicly trade on @Nasdaq under ticker “KRRO” starting 11/6. We appreciate the support of our investors: bitly.ws/Znim
Ellen Schmidt retweeted
Always great to catch up with @UMich grad school friends! Go Blue! 〽️💙 #ASHG23
@Jasamack @m_t_mcnulty @AbhayHukkuBST @ellenmschmidt @weizhouw @tidnapatina @wu_khh Sarah Hanks & Aubrey Annis
Ellen Schmidt retweeted
Today is #InternationalDayOfWomenAndGirlsInScience, and as we salute efforts to support equitable participation in STEM industries, we also recognize the massive contributions women have made at Korro!
More on the event: bit.ly/32FUdtW
Excited to be a part of the @VesaliusTx team as we launch from stealth mode today!
Flagship launches Vesalius Therapeutics (@VesaliusTx) to redefine the understanding and treatment of the diseases that drive ninety percent of human illness. Read release: bit.ly/3tqghlp & visit: vesaliustx.com @DougCole2
Check out our newly published work on systematic drug target prioritization from Open Target Genetics! 👇
Read all about the latest updates to Open Targets Genetics in @NatureGenet!
The Genetics Portal enables users to easily prioritise genes at disease and trait-associated loci and assess their potential as drug targets.
👉nature.com/articles/s41588-0…
Or keep scrolling for a recap🧵
Ellen Schmidt retweeted
Excited to share our preprint on the challenges of expressing SARS-CoV-2 S protein as transgene and how introns came to rescue. A simple question back in last May led to an unexpected finding, filing my first patent application and starting a company🤯🧵 biorxiv.org/content/10.1101/…
Huge congratulations to my thesis advisor and mentor @cristenw for winning the 2021 @GeneticsSociety Early Career Award! So well-deserved! 👏
ashg.org/publications-news/p…
Shout out to my brilliant science sisterhood, both near and far. You are such a powerful inspiration! 👩🔬👩💻🧬🌎 #WomenInScienceDay #WomenInScience #WomenInSTEM
Ellen Schmidt retweeted
Very glad to share the preprint for our web-based GWAS visualization tool, LocusZoom.js (and associated services). This has been a long-running team effort, including strong driving use cases with the @T2DKP team and others. Try with your own data at my.locuszoom.org .
LocusZoom.js: Interactive and embeddable visualization of genetic association study results biorxiv.org/cgi/content/shor… #bioRxiv
Brooke Wolford @bnwolford performs benchmarking of polygenic and conventional risk factor models for CVD traits in @theHUNTstudy. Using metaGRS with conventional risk factors, 10.5% of participants that would be reclassified as high risk have a CAD event within 10 years. #ASHG20
One take-home from the bioethics discussion: Science is not value-neutral. It only answers the questions we ask, and we should always think about whether the questions we are asking are the right ones or not. #ASHG20
Eddie Cano Gamez @eddiecg detects 9,186 eQTLs during CD4+ T cell activation; identifies 219 colocalizations between eQTLs and immune disease loci, half of which involve dynamic eQTLs. @targetvalidate #ASHG20
#ASHG2020 Minzhi Jiang gives a clear explanation of reasons to use Canonical correlation analysis (CCA) rather than PCA for multi-omics data integration.
Ryan Schubert uses multi-ethnic TOPMed MESA proteome to compare standard elastic net with fine mapped elastic net regression; fine mapped model predicts more proteins. #ASHG20
Next, @kerencarss on phenome-wide gene-based analysis of rare loss-of-function and missense variation in 300K UKB exomes for 19K phenotypes. Tests 4.4 billion associations in <24 hours and identifies 949 and 767 significant associations for binary and quantitative traits. #ASHG20
Kicking off platform session, Computational Methods for Association Studies, is Kavita Praveen: Exome-sequencing + meta-analysis of 4 cohorts: (116K cases, 347K controls) identifies rare, coding variants in Mendelian hearing loss genes that span the spectrum of severity. #ASHG20
President Wynshaw-Boris opens virtual #ASHG20 by characterizing ASHG as a BIG TENT: An inclusive umbrella that accommodates a diverse set of geneticists from throughout the world. Asks, how do we move forward in an ever-changing world presenting new, unforeseen challenges?
2020 just got a little better 🤗
Surprise 🤗 Tonight at midnight I’ll be releasing my 8th studio album, folklore; an entire brand new album of songs I’ve poured all of my whims, dreams, fears, and musings into. Pre-order at store.taylorswift.com
Ellen Schmidt retweeted
**Postdoc & PhD opportunities**
Interested in using large genomic datasets to discover and analyse non-coding variants that cause rare diseases?
Come work @HumanGeneticsOx @UniofOxford
whiffinlab.org/join-us
Please share and RT!
But why should you join my team? A thread 1/4