Excited to share our work on the host genetic landscape of invasive meningococcal disease! Karin van Leeuwen, @SanchoShimizu, Taco Kuijpers @amsterdamumc
jacionline.org/article/S0091…
An incredible 10-year+ effort by the @EUCLIDS_FP7 consortium and collaborators!
The complement and coagulation pathways are implicated in invasive meningococcal disease (MD). How might genetic variation contribute to disease? A study applies gene burden analysis and pathway-based approaches to a cohort of children with MD. Read on. bit.ly/4pnnsH5
Our new computational technique #burdenMC used to identify enrichment of rare variants in gene regulating the gut lining in patients with MIS-C. @dilyssantillo @SanchoShimizu @JExpMed
doi.org/10.1084/jem.20240699
Bellos, Santillo, @SanchoShimizu et al. identify an enrichment of rare, damaging variants in BTNL8 in MIS-C patients resulting in impaired Vγ4⁺ γδ T cell engagement associated with altered gut homeostasis which may contribute to the pathogenesis of MIS-C. hubs.la/Q02Z9_kK0
Evangelos Bellos retweeted
Bellos, Santillo, @SanchoShimizu et al. identify an enrichment of rare, damaging variants in BTNL8 in MIS-C patients resulting in impaired Vγ4⁺ γδ T cell engagement associated with altered gut homeostasis which may contribute to the pathogenesis of MIS-C. hubs.la/Q02Z9_kK0
Evangelos Bellos retweeted
Christmas came early - just received our new @nanopore toys! Looking fwd to the first sequencing data! 🔬🎄 @taniapsduarte @ebellos @jetpackjeth & @lachlancoin #nanopore #MinION
Evangelos Bellos retweeted
Not a bad start for Monday morning! Well done winning team: @SanchoShimizu @acunningID @jetpackjeth @ebellos 🏆💪 @ImperialMed
Evangelos Bellos retweeted
Scaffolding and completing genome assemblies in realtime with nanopore sequencing from the @lachlancoin lab @IMBatUQ nature.com/articles/ncomms14…
Evangelos Bellos retweeted
Streaming algorithms for ID'ing pathogens & antibiotic resistance potential from MinION sequencing #GigaScience bit.ly/2acBrwc
Evangelos Bellos retweeted
Thomson Reuters Predicts #2014 #Nobel #Laureates tmsnrt.rs/1xnrkue GO CNVs!! @thomsonreuters @lachlancoin @ebellos
Evangelos Bellos retweeted
#PLOSMedicine: A Transcriptional Signature for Active #TB: Have We Found the Needle in the Haystack? dx.plos.org/10.1371/journal.… #diagnostics
Evangelos Bellos retweeted
cnvHiTSeq: CNV discovery + genotyping method from @lachlancoin & co, uses integrative probabilistic approach bit.ly/12A8rmM #genomics