Human pluripotent stem cells allow scientists to model human tissues and organs without using animals, but labeling cell types and states accurately can be tricky. In this perspective, @twatkeson and colleagues propose a “stem cell-relevant manifold”—a large reference map combining human tissue and stem cell-derived data. This could improve cell annotation, make lab-grown cells more physiologically accurate, and speed insights into development, disease, and potential therapies. Read in @stemcellreports: cell.com/stem-cell-reports/f… 👥 @Elias_RuizMor, @roserventotormo, @drneavin, @drjosephpowell, et al. 🏛️ @GarvanInstitute, @reNEW_Global, @sangerinstitute, @SCICambridge, @CellularFutures 💰 @nhmrc, @reNEW_Global, @wellcometrust