Don Le (@dusk2don) header
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Don Le

@dusk2don

Former 2019 Chair of @texpathol DCS | Former Pathology Resident @bswhealth | Former Cytopathology Fellow @bcmhouston | Surgical Pathology Fellow @methodisthosp

 Houston, TX
Joined June 2011
  • Tweets124
  • Following197
  • Followers656
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Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)Photo by Don Le (@dusk2don)
Image from Ahmed Shehabeldin (@Anshehabeldin)
Image from Ahmed Shehabeldin (@Anshehabeldin)
Image from Ahmed Shehabeldin (@Anshehabeldin)
Image from Ahmed Shehabeldin (@Anshehabeldin)
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Here's a rare but well defined entity: "Papillary thyroid carcinoma with desmoid type fibromatosis" Two components of the tumour: 1) BRAFV600E positive papillary thyroid carcinoma 2) Desmoid type fibromatosis (nuclear expression of beta-catenin) So unusual-deserves a retweet!
Image from Anthony J Gill (@CaDxPath)
Image from Anthony J Gill (@CaDxPath)
Image from Anthony J Gill (@CaDxPath)
Image from Anthony J Gill (@CaDxPath)
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Malakoplakia presenting as a renal mass- histiocytes (von Hansemann cells) with Michaelis-Gutmann bodies. Shown HE & Calcium stain- one of the best I have seen! #kidney #gupath #pathology #MedTwitter #pathresidents @UMichPath @UMichUrology
Image from ROHIT MEHRA (@drmehrarohit)
Image from ROHIT MEHRA (@drmehrarohit)
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I got a request to post the images from the case I presented at this year's USCAP "Kidney and Beyond" session. So here it is again in all of its insane glory... Intraglomerular metastasis of a poorly-differentiated salivary gland primary.
Image from Jean Hou, MD (@JeanHouMD)
Image from Jean Hou, MD (@JeanHouMD)
Image from Jean Hou, MD (@JeanHouMD)
Image from Jean Hou, MD (@JeanHouMD)
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Dx: HPV-related adenosquamous carcinoma Teaching points: 1) Soft palate is oropharynx, always consider HPV-related carcinomas in OP 2) Ages of HPV+ OP carcinomas is rising (this pt was 82) 3) HPV+ adenosquamous CA looks weird, salivary-like (esp MEC), doesn't follow the "rules"
Image from J. Bishop (@ENTpathology)
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Coexistence of DCIS and LCIS (with invasive lobular carcinoma) True “collision” or “progression” from ductal to lobular phenotype (as a member of low grade breast neoplasia family) ❓🤪 #breastpath #pathology #surgpath
Image from Taywin Atikankul (@AtikankulTaywin)
Image from Taywin Atikankul (@AtikankulTaywin)
Image from Taywin Atikankul (@AtikankulTaywin)
Image from Taywin Atikankul (@AtikankulTaywin)
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I saw yesterday's GEJ case when I was in training. It was signed out as polypoid Barrett's with high-grade dysplasia. I got a teaching recut. A few years later, I came across it, took a look, and said wait a sec ... that's a pyloric gland adenoma! #pathology #gipath
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
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I hope everyone enjoyed yesterday's case of an epidermoid cyst arising in an intrapancreatic accessory spleen. #pathology #gipath
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
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Yesterday's case ... so I never believed in "inflammatory myoglandular polyp," until I saw (and diagnosed) this case. Hope I was right! #pathology #gipath
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
Image from Raul S. Gonzalez, MD (@RaulSGonzalezMD)
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Since we all need a tiny bit less of stress & a tiny bit more of educational material, I thought I would share with you this beauty.. *Middle-age F, breast Bx* #BreastPath #SurgPath – at Montréal, Québec
Image from Greta Evaristo, MD (@gtevaristomd)
Image from Greta Evaristo, MD (@gtevaristomd)
Image from Greta Evaristo, MD (@gtevaristomd)
Image from Greta Evaristo, MD (@gtevaristomd)
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Solid pseudopapillary neoplasm of pancreas it is 👏 ➡️young female,tail mass ➡️cyto:papillary fronds,bland tumor cells,hyaline globules,nuclear grooves ➡️DDX:PNET(SPN can be NE markers+ mostly CD56, Synpato less chromo) ➡️nuclear beta-catenin+(CTNNB1 mutation) #GIpath #pathboards
Image from Aysha Mubeen (@AMubeen_Path)
Image from Aysha Mubeen (@AMubeen_Path)
Image from Aysha Mubeen (@AMubeen_Path)
Image from Aysha Mubeen (@AMubeen_Path)
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Pleomorphic lipoma. Fat, ropey collagen, myxoid, hyperchromatic pleomorphic cells with floret/wreath multinucleation. Atypical but benign. Loss of 13q (RB1) or 16q. #pathology #BSTpath pics: @kusaurap
Image from Jerad Gardner, MD (@JMGardnerMD)
Image from Jerad Gardner, MD (@JMGardnerMD)
Image from Jerad Gardner, MD (@JMGardnerMD)
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Histoplasmosis: 2-4 micron yeasts with narrow-based budding commonly within macrophages. Buzz words: bird or bat droppings, Ohio, Mississippi. Touch prep of retroperitoneal lymph node.
Image from Don Le (@dusk2don)
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Great tips for telling osteoblasts from plasma cells in bone by @KyleBradleyMD #pathology #hemepath #BSTpath
Image from Jerad Gardner, MD (@JMGardnerMD)
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Gangliocytic paraganglioma (GPG) - perhaps one of the most enigmatic pathology entities! Classic location - D2/periamp (rarely spinal cord) EGD - nodule/bump Histo- 3 components - 1. Endocrine - carcinoid/paraganglioma-like 2. Schwannian/spindle cell 3. Ganglion cells #GIpath
Image from Monika Vyas (@Mvgs1706)
Image from Monika Vyas (@Mvgs1706)
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Melanoma simulating pulmonary adenocarcinoma with areas of interstitial and lepidic-like growth, in and amongst the pneumocytes. The stuff of nightmares. Keratin and Melan A pictured, S100 and SOX10 also positive.
Image from Jennifer Boland, MD (@JenniferBoland7)
Image from Jennifer Boland, MD (@JenniferBoland7)
Image from Jennifer Boland, MD (@JenniferBoland7)
Image from Jennifer Boland, MD (@JenniferBoland7)
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Been ages since I did this, hope I remember how. Recent case, 82-year-old woman, large soft palate mass, pictured here. #headandneckpathology #ENTPathology #ENTpath #oralpath
Image from J. Bishop (@ENTpathology)
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Case I very nearly eff’ed up: 42 year old man, 3.5cm mass apparently arising from the gastric serosa. Will post some IHCs in a bit. #GIpath #BSTpath @IHC_guy @JMGardnerMD @TxicMegacolon @LizMontgomeryMD @CArnold_GI
Image from Brian McMillen MD (@Teclis82)
Image from Brian McMillen MD (@Teclis82)
Image from Brian McMillen MD (@Teclis82)
Image from Brian McMillen MD (@Teclis82)
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