DIPG scientist | Underwater exploration | #DunLab post doc | https://xitter.cf/t.co/enliHkVrUx
Newcastle, NSW
Joined April 2020
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Had a wonderful afternoon playing monopoly supporting the #LittleLegsFoundation for beautiful Alegra. Thank you for all you do to support #dunlab and DIPG research. @evierjackson @mika persson
So great to see our review article on targeting CLPP out in print. Beautiful work from @evierjackson, @Mika_Persson97 and @MattDun17.
Huge congrats to @evierjackson @Mika_Persson97 & @duchatel_ryan for leading this & #DunLab team & wonderful #DMG #DIPG colleagues for your support.
"Current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered" academic.oup.com/neuro-oncol…
Dr Ryan Duchatel retweeted
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma: buff.ly/3TAz4Jd
@MattDun17 @childrenshealth @Uni_Newcastle
#Oncology #Therapeutics
Thank you @RobertReya for the fantastic and considered commentary on our recent @jclinicalinvest publication on PI3K/PKC in DIPG/DMG.
jci.org/articles/view/179144
Proud to see our paper targeting PI3K in DMG on the cover of JCI. Thank you to all those who assisted this work, in particular my amazing colleague @evierjackson and mentor @MattDun17.
#Cover: Targeting PI3K/mTOR in diffuse intrinsic pontine glioma: buff.ly/3TAz4Jd
#Image presents a model whereby the connectivity of these cancers can be harnessed using integrated technologies to identify potential therapeutic strategies.
#Oncology #Therapeutics
Dr Ryan Duchatel retweeted
#Cover: Targeting PI3K/mTOR in diffuse intrinsic pontine glioma: buff.ly/3TAz4Jd
#Image presents a model whereby the connectivity of these cancers can be harnessed using integrated technologies to identify potential therapeutic strategies.
#Oncology #Therapeutics
The combination of paxalisib and the PKC inhibitor Enzastaurin synergistically extended the survival of a number of aggressive pre-clinical DIPG/DMG models. (5/11)
This project was truly collaborative, with a number of researchers and groups contributing from across many countries. @DKiltschewskij, @DilanaStaudt, @Bryce_Thomas23, @Zacger, @DrLizzieManning, @DeVerrills, @DavidSkerrettB, @BrettNixon13, @DrSusanHua, @charles_debock (10/11)
Proud to highlight the recent publication of our #DunLab project (@MattDun17) in @jclinicalinvest identifying PI3K as a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma (DIPG/DMG). Thread... (1/11)
jci.org/articles/view/170329
Clinically, resistance to PI3K inhibitors is mediated by insulin feedback caused by hyperglycemic side effects following PI3K inhibition. Paxalisib in combination with the anti-glycemic drug metformin reduced these side effects and improved efficacy in pre-clinical models. (3/11)
CRISPR-Cas9 screening identified PIK3CA and MTOR as genetic dependencies in all 38 DIPG/DMG models studied and sensitivity to the blood brain barrier penetrant, PI3K inhibitor paxalisib, independent of mutational states @KaziaTx (2/11)
Dr Ryan Duchatel retweeted
This Christmas, our hearts carry a bittersweet ache as we reflect on the children who should be here laughing and celebrating with their families but are no longer physically present. Our hearts are with everyone who has an empty spot at their table during this holiday season.
Dr Ryan Duchatel retweeted
Editor’s view: Stop the lip service, and cough up some cash
Thanks Mick Carroll for voicing the words of every #DIPG #DMG parent, family, friend, clinician, researcher and carer!
dailytelegraph.com.au/news/o… via @dailytelegraph – at Putta Bucca - Bombira, New South Wales