MD. Life Sciences x AI. Ex. McKinsey/BCG/Takeda/Astrazeneca.

Boston, MA
Joined October 2010
Friends, there is a common view of God as the supreme being among many beings—as the biggest and greatest of all beings. But this is a false understanding of God, who is, as Aquinas says, “ipsum esse subsistens”—the sheer act of “to be” itself. In other words, he is the creative ground from which all finite reality comes. God is not a being in the world like the ancient mythological gods and goddesses but the creative source of all that is.
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Emir Roach retweeted
Here the 50+ ADCs that will be discussed at #ESMO26 next week, divided by payload class and target. B7-H3 TOPO1i leads, with 7 different ADCs! (Note: TiP and ePoster not included)
Only 2 weeks until the @myESMO 2026 Congress in Madrid! For ADCs: ▪️ 210+ regular abstracts and 23 Late-Breaking Abstracts (LBAs) accepted ▪️ 50+ talks, 120+ posters, and 60+ ePosters 👇👇 Here the list of the 14 ADCs being presented for the first time at #ESMO26!
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Emir Roach retweeted
Dusting off this tweet from April because this gap in shared understanding of LLM capability is *widening*. It's now less "two groups of people speaking past each other" and more a sharp funnel. - Napkin math somewhere around 6B people (~75% of the population) have barely come in contact with LLMs at all. - Around 1-2B (~20%) are casual and infrequent users of free-tier ChatGPT-like products. This group sees derpy chatbots and treats them a bit like a better Google search, a writing aid, or etc. Maybe an agent tries to book you a flight. I have non-tech friends who (reasonably, imo) say they have not much use for it at all. Even many professionals outside of math&code are in this tier. For example, execs and many other functions spend a lot of their time talking to other people, so while they understand what is happening intellectually, it is still second-hand and a bit abstract. - Now we get to professional use of frontier-grade LLMs in math&code. Somewhere around 20M people (0.2%) see first-hand that large, complex projects that used to take them weeks/months can now be completed by agents with a prompt. Building apps, copying apps, translating apps, decompiling apps from binaries... This has all happened very quickly and recently - less than 1 year ago, I was writing code manually by hand, typing memorized computer code commands into a code editor character by character, occasionally pressing Tab to autocomplete a little chunk of code. - And finally we get to the ~5,000 people (~0.00006%) with access to frontier-grade systems internally. The external world has seen the preview. It looks like swarms of thousands of agents collaborating over weeks on software mega projects: minting zero days, running cyber attacks and defenses at machine speeds, discovering new science, advancing the frontier of mathematics. Things that would have taken top professionals in the industry years of work. Meanwhile, human review and comprehension are starting to fall behind. For example, people are still involved in the "archeology" of the OpenAI-HF incident from many months ago. Mathematicians may be poring over the 722 manuscripts on frontier mathematics for a while. The funnel is driven by a combination of factors: 1. The impact scales with ambition, problem size, and horizon. A question with a paragraph answer barely stresses the system. You need a reservoir of big, difficult problems that you really care about. This aspect drives the consumer / professional dimension of the funnel. 2. The jaggedness of the system (which I have written about a lot separately). Capability peaks in domains that are digital, verifiable and economically valuable. This is because LLM capability emerges from reinforcement learning on verifiable rewards on a curated environment mixture driven by revenue potential. This aspect primarily drives the area (e.g. math&code) dimension of the funnel. 3. Access. Free-tier, paid-tier, internal. So this is the weirdness of the moment. The general public has mostly not interacted with these systems. When they have, it looks like a derpy chatbot. The majority of professionals still see only a modest uplift. And a small sliver of professionals are experiencing the vertigo of the curve going vertical. And it is all happening at the same time.
Judging by my tl there is a growing gap in understanding of AI capability. The first issue I think is around recency and tier of use. I think a lot of people tried the free tier of ChatGPT somewhere last year and allowed it to inform their views on AI a little too much. This is a group of reactions laughing at various quirks of the models, hallucinations, etc. Yes I also saw the viral videos of OpenAI's Advanced Voice mode fumbling simple queries like "should I drive or walk to the carwash". The thing is that these free and old/deprecated models don't reflect the capability in the latest round of state of the art agentic models of this year, especially OpenAI Codex and Claude Code. But that brings me to the second issue. Even if people paid $200/month to use the state of the art models, a lot of the capabilities are relatively "peaky" in highly technical areas. Typical queries around search, writing, advice, etc. are *not* the domain that has made the most noticeable and dramatic strides in capability. Partly, this is due to the technical details of reinforcement learning and its use of verifiable rewards. But partly, it's also because these use cases are not sufficiently prioritized by the companies in their hillclimbing because they don't lead to as much $$$ value. The goldmines are elsewhere, and the focus comes along. So that brings me to the second group of people, who *both* 1) pay for and use the state of the art frontier agentic models (OpenAI Codex / Claude Code) and 2) do so professionally in technical domains like programming, math and research. This group of people is subject to the highest amount of "AI Psychosis" because the recent improvements in these domains as of this year have been nothing short of staggering. When you hand a computer terminal to one of these models, you can now watch them melt programming problems that you'd normally expect to take days/weeks of work. It's this second group of people that assigns a much greater gravity to the capabilities, their slope, and various cyber-related repercussions. TLDR the people in these two groups are speaking past each other. It really is simultaneously the case that OpenAI's free and I think slightly orphaned (?) "Advanced Voice Mode" will fumble the dumbest questions in your Instagram's reels and *at the same time*, OpenAI's highest-tier and paid Codex model will go off for 1 hour to coherently restructure an entire code base, or find and exploit vulnerabilities in computer systems. This part really works and has made dramatic strides because 2 properties: 1) these domains offer explicit reward functions that are verifiable meaning they are easily amenable to reinforcement learning training (e.g. unit tests passed yes or no, in contrast to writing, which is much harder to explicitly judge), but also 2) they are a lot more valuable in b2b settings, meaning that the biggest fraction of the team is focused on improving them. So here we are.
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Emir Roach retweeted
Technical moats are mostly over at this point. If you’re building something that is meant to be durable, the only moats now are: • Proprietary data • Network effects • A physical component
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Emir Roach retweeted
In an age dominated by technology, in which efficiency and profit often take precedence, it is so important that we continue to cultivate a spirit of contemplation and allow time and space for beauty. Such an attitude will greatly help humanity, especially young people, to discover the ability of art to uplift and reveal the depths of the human spirit and our openness to the divine. Contemplation presents a marvelous opportunity to encounter the God who is Beauty.
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Emir Roach retweeted
Today, Nolla Health became the first organization in the U.S. (and possibly the world) to receive regulatory approval for an AI to issue initial prescriptions. This makes Nolla the first ever actual end-to-end AI doctor.
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Pick any medical specialty other than your own. Who’s the most famous physician in it? You probably can’t name one. Almost none of us will be known outside our field, and even those who achieve real professional fame are mostly forgotten within a few decades. Fame is a poor reason to devote your life to medicine. The work itself matters more: caring for patients, discovering new knowledge, and teaching the next generation.
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Emir Roach retweeted
Many people are rediscovering the Gospel and embracing the faith against the backdrop of a society marked by a deeply secularized culture. With pastoral tenderness and fraternal charity, we must recognize, welcome, and protect the small flame that the Holy Spirit has kindled in the darkness of the night. #ApostolicJourney #France vatican.va/content/leo-xiv/e…
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Hardly anyone on Earth understands the magnitude of this. It's actually happening right now. Crazy that we get to witness it close up.
🤖 Made with AI
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Opus 5.5 is amazing. Well done @AnthropicAI
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We’re working with an independent advisory group of mathematicians to help OpenAI responsibly share advances in AI and mathematics. The group will advise on how we assess and communicate new mathematical results, uphold academic and professional standards, and build tools that support mathematical research and learning. Through this work, we want mathematicians to be at the center of shaping how AI supports mathematical understanding and how its benefits reach the wider community. openai.com/index/advisory-gr…
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ADC field's uneven maturity: Diversification in targets, consolidation in payloads Source: cell.com/cell/abstract/S0092…
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“Duc in altum.” Put out into the deep. St. John Paul II repeatedly returned to Christ’s words to Peter in Luke 5:4 as a call to courage—a call to leave the safety of the shore and trust Christ in deeper waters. He challenged a generation: “Do not be satisfied with mediocrity.” “Do not be afraid to be holy!” And he reminded us that when Christ calls us into the deep, we do not go alone. Faith was never meant to be comfortable. Do not be afraid. Go deeper. Put out your nets. "Duc in altum." — Jim Caviezel
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Good review
Drs. Tarek H. Mouhieddine and Kenneth C. Anderson summarize treatment for multiple myeloma, highlighting four-drug induction therapy, evolving transplantation strategies, tailored maintenance therapy, and in relapse, earlier use of BCMA-directed immunotherapy. Read the Review Article “Treatment Decisions in Multiple Myeloma”: nej.md/4cDwLOF
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Emir Roach retweeted
Yes, this result cost millions of dollars. But remember that when @OpenAI announced o3 it cost ~$500,000 to score 87.5% on ARC-AGI 1. Today, Astra scores higher for ~$20. In 2025 it took us and GDM an enormous amount of compute to achieve IMO gold. For the 2026 IMO, anyone with a $20/month ChatGPT subscription could do it. Massively scaling test-time compute gives us a glimpse of the future. I believe that a year from now everyone will have an AI at their fingertips capable of solving problems of this caliber.
We’re sharing a solution to the Navier-Stokes Millennium Prize Problem, one of the deepest problems at the frontier of mathematics. The proof was produced by a group of agents, using an OpenAI next-generation model significantly more capable than GPT-6 Astra. The problem concerns whether the description of smooth three-dimensional fluid motion modeled by the Navier-Stokes equations can break down. It has remained unresolved for roughly 90 years.
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Emir Roach retweeted
We’re sharing a solution to the Navier-Stokes Millennium Prize Problem, one of the deepest problems at the frontier of mathematics. The proof was produced by a group of agents, using an OpenAI next-generation model significantly more capable than GPT-6 Astra. The problem concerns whether the description of smooth three-dimensional fluid motion modeled by the Navier-Stokes equations can break down. It has remained unresolved for roughly 90 years.
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Emir Roach retweeted
This is like that first video of Will Smith eating spaghetti all over again See you all in 2030
okay Astra time to rickroll
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Friends, for the wokeist philosophy that dominates today, empathy—feeling the feelings of the other and not harming those feelings—is treated as a supreme value. But while empathy is perfectly good and decent, the Bible teaches that love, not empathy, is the supreme value. And love does not mean, primarily, feeling the feelings of the other or not hurting those feelings; it means willing the good of the other—and that can be, as Dostoevsky said, “a harsh and dreadful thing.”
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Emir Roach retweeted
Engineering our immune cells has successfully treated many types of cancer and even led to cure of some autoimmune diseases. But the engineering of cells was done outside the body, is highly complex, takes 3 to 6 weeks, and is not scalable. But now there are many in vivo (inside the body) Phase 1 clinical trials reading out soon. Watch this space. nature.com/articles/d41573-0…
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Emir Roach retweeted
The revolution in pancreatic cancer is not just about the new, impressive FDA approved drug or the vaccine treatment. It's also about AI detection up to 3 years before it is currently diagnosed. wsj.com/opinion/fda-approves…
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