@drjackpgreen

Presidential Fellow at the University of Manchester. Researching inflammasomes and molecular mechanisms of inflammation

 Manchester, England
Joined October 2017
  • Tweets206
  • Following245
  • Followers325
7Media
Very happy to share our latest study out now in @JCellBiol! We describe a new way in how macrophages translate cell volume changes to sense danger and drive inflammation. Check it out here hubs.la/Q04fQS5V0

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling

Cook et al. show that macrophages sense cell volume disruption as a danger signal promoting transcriptional reprogramming and inflammatory responses via ty

rupress.org
Journal of Cell Biology@JCellBiolMay 7
Cook, Green et al. @OfficialUoM show that #macrophages sense cell volume disruption as a danger signal promoting transcriptional reprogramming and inflammatory responses via type I interferon signaling. hubs.la/Q04fQS5V0 #Inflammation #CellSignaling #Immunology
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Exciting opportunity to join the Brough lab as a PDRA for 3 years studying the NLRP3 inflammasome. More details here - jobs.manchester.ac.uk/Job/Jo…

Research Associate in Inflammation Research:Oxford Road

jobs.manchester.ac.uk
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Join us for our next Inflammazoom on Dec 15th with our two exciting speakers Sid Balachandran and Marcus Taylor
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New pre-print from the lab: Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells. biorxiv.org/content/10.1101/… @BiologyatYork @YBRI_UoY @The_MRC

Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer cells

Inflammasomes are critical in rapidly responding to infections and tissue damage, with current paradigms centred on macrophages and epithelial cells. Natural Killer (NK) cells are innate lymphoid...

biorxiv.org
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Do not miss this! #inflammazoom is back in October 🎉 with James Murphy from WEHI and Jonathan Maelfait from VIB Ghent we are back with some really 🔥 stories!
Abcam
@abcam8 Oct 2025
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: bit.ly/4iXGqjw #InflammaZoom #innateimmunity #inflammasomebiology
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Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
Journal of Experimental Medicine@JExpMed2 Sep 2025
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. hubs.la/Q03GtbGx0
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One week to go! 🎉 Join us on 11th September for an amazing innate immunology showcase. Don’t miss out - register today! bit.ly/43q9x9r
Dave Boucher@dave_boucher1 Sep 2025
Still time to sign up! La crème de la creme of innate immunity in the Uk! Join us for an exciting 2 days of science!
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Last chance! The early bird registration for the innate immunity & inflammation UK 2025 meeting in Manchester closes TONIGHT at 23:59 BST. Don’t miss your opportunity to save and be part of this important event. Register now before the deadline hits! bit.ly/43q9x9r
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Don’t miss out! The early bird deadline for 'Innate immunity & inflammation: UK inflammation 2025 meeting' in Manchester is just 1 week away! Secure your place now for discounted registration fees. 🐦 Register now before the early bird offer flies away! bit.ly/43q9x9r
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🐦Early bird registration for our UK inflammation 2025 meeting closes soon, on 27 August! Don’t miss your chance to save on this event in Manchester, 11-12 Sept. Register today and secure your spot before the deadline! bit.ly/43q9x9r
BSI Congress & Events@bsicongress30 Jul 2025
Discover advances in innate immunity & inflammation at our event in Manchester, 11-12 Sept! We’ve had an incredible response with a high number of abstracts submitted – register today to be part of this discussion. Early bird registration ends soon 👀 bit.ly/43q9x9r
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New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…

10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry,...

Caspases are a family of cysteine proteases conserved across all metazoa which play critical functions that range from cell death, inflammation, and cellular differentiation. Caspases cleave a subset...

jbc.org
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Discover advances in innate immunity & inflammation at our event in Manchester, 11-12 Sept! We’ve had an incredible response with a high number of abstracts submitted – register today to be part of this discussion. Early bird registration ends soon 👀 bit.ly/43q9x9r
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📢 Last chance to showcase your groundbreaking work on innate immunity & inflammation! The abstract deadline for our UK inflammation 2025 meeting in Manchester is TOMORROW. Don’t miss the opportunity to present your research! Click here to submit - bit.ly/43q9x9r
BSI Congress & Events@bsicongress17 Jul 2025
Did you miss your chance to submit an abstract for our UK inflammation 2025 meeting focussing on innate immunity and inflammation? 📢 Great news! The submission deadline has been EXTENDED to Thursday 24 July. Submit your abstract here: bit.ly/43q9x9r
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Abstract deadline coming up fast - 15th July! Don’t miss the chance to be part of this fantastic meeting. Great opportunities for ECRs to present their research. Submit your abstract here! bit.ly/43q9x9r
BSI Congress & Events@bsicongress26 Jun 2025
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with @BSI_Inflam on 11–12 Sept in Manchester! Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July! ☑️ Submit your abstract & register: bit.ly/43q9x9r
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Join us in September for this excellent event showcasing the latest in innate immune signalling and inflammation - An amazing line-up of speakers and plenty of opportunities for ECRs to share their research!
BSI Congress & Events@bsicongress28 May 2025
Dive into cutting-edge innate immunity & inflammation science at our event on September 11! From immune cell roles to inflammasome signalling, discover advances shaping clinical care. Abstract deadline: 15 July Early bird registration ends: 27 August 🔗 bit.ly/43q9x9r
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I'm delighted to be hosting a #NLRP3 @InflammaZoom spectacular next week! With @Innate_immuno and @anatapia85 - please join us on Monday 19th May. Register here: events.abcam.com/event/Infla…
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Our preprint “Lysosome positioning affects NLRP3 inflammasome activation” is out! Excited to share the work from my PhD project. Big thanks to the amazing scientists who collaborated on this study! biorxiv.org/content/10.1101/…

Lysosome positioning affects NLRP3 inflammasome activation

The NLRP3 inflammasome, an important multi-molecular protein complex driving inflammation, is activated by multiple cellular stresses, including a loss of organelle homeostasis. Studies indicate that...

biorxiv.org
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🚨 UK Cell Micro 2025 is here! 🚨 📅 2nd-3rd June 2025 📍 King’s College London Join us for fun science, networking, and a rooftop social! 🌇🎉 💡 Submit your abstract by 10th April ukcellmicro.org
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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/scia…

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death...

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

science.org
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📢 I'll be hosting Jack Auty @mere_conjecture & Kesavardana Sannula @keshu_VRimmCh for the next @InflammaZoom session on Monday 20th Jan at 8am GMT, 1:30pm IST, 7PM AEDT. Register here: events.abcam.com/event/Infla…
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