Stranger in a Strange Land
Chandigarh, India
Joined May 2021
- Tweets849
- Following369
- Followers1.2K
- Likes1.4K
M PREMKUMAR retweeted
🧬 Our new paper in @JCEH_Hepatology is out!
In 69 North Indian MASLD patients genotyped for 12 candidate SNPs, we found that APOC3 and PNPLA3 operate on distinct genetic axes:
🔸 APOC3 rs2854116 — enriched in MASLD vs Indian population (OR 1.93, P<0.001) but NO fibrosis association → susceptibility variant
🔹 PNPLA3 rs738409 — strongest fibrosis predictor (OR 2.89, P=0.006) → severity variant
🔥 Carriers of risk alleles at ALL 3 loci (APOC3+PNPLA3+SAMM50) had 90% fibrosis prevalence (OR 13.7, P=0.0001)
Who gets the disease ≠ who gets worse. Ancestry-specific genetic data matter.
#MASLD #LiverTwitter #Genetics #PNPLA3 #APOC3 #Hepatology #JCEH #IndianGenomics
sciencedirect.com/science/ar…
M PREMKUMAR retweeted
New issue alert ⚠️📙
Dear Readers,
The latest issue Volume 45, Issue 5 of IJG is out. Happy reading 📖🙂
#science #sciencejournal #IJG #ISG #Springer #SpringerNature #journals
link.springer.com/journal/12…
@drvishal82 @DrAnuraagJ @IJG_Journal @UshaPGIMER @drsridhars @docMPK
M PREMKUMAR retweeted
Continuing our work on recomp-
1/3rd of AIH also can recomp.
AIH-PBC -25%
AIH-PSC none
link.springer.com/article/10…
@RoyAHep @karanbjmc93 @docMPK @BavenoCoop @ReibergerThomas @JimmyLaiCT @TerryYip12 #LiverX
🚨 Recompensation in decompensated AIH cirrhosis
🔹34% achieved Baveno VII recompensation
🔹 Transplant-free survival was 97% vs 63%* with vs without recompensation
🔹 20% re-decompensated
Recompensation in AIH is real but dynamic.
link.springer.com/article/10…
M PREMKUMAR retweeted
🚨 Recompensation in decompensated AIH cirrhosis
🔹34% achieved Baveno VII recompensation
🔹 Transplant-free survival was 97% vs 63%* with vs without recompensation
🔹 20% re-decompensated
Recompensation in AIH is real but dynamic.
link.springer.com/article/10… – at Kolkata, India
M PREMKUMAR retweeted
🇮🇳 Real-world data from >1000 patients with MASLD/MetALD
MRI-PDFF phenotyping + 🧲 MRE anchor
🔍 Key takeaways:
✔️ Similar CMRF & AF burden
✔️ FIB-4 & NFS perform well
❌ APRI underperforms
💡 Simple NITs even for MetALD
@AnandVKulkarni2 @DrMaheshgoenka
link.springer.com/article/10…
M PREMKUMAR retweeted
🧵NEW STUDY PUBLISHED
Our DiaFib-Liver Study is now published in @LancetRH_SEAsia.
The largest-ever real-world survey of liver fibrosis in type 2 diabetes from any low- or middle-income country.
9,202 patients. 82 doctors. Pan-India. 🇮🇳
🔗 authors.elsevier.com/sd/arti…
M PREMKUMAR retweeted
#Fibrosis prevalence across clinical subgroups:
Highest: CAD (33%),
eGFR <60 (33%),
Obesity (32%),
Dyslipidaemia (30%)
Even without obesity: 19%
Dashed line = overall prevalence (26%).
No difference by sex or hypothyroidism.
Fibrosis is widespread across ALL subgroups.
M PREMKUMAR retweeted
*New Issue Alert*
The special IJG Women and Gastroenterology March-April issue (Volume 45, Issue 2) is online.
Please have a look:
link.springer.com/journal/12…
@IJG_Journal @docMPK @drvishal82 @drsridhars @DrAnuraagJ @giri_gutnliver @UshaPGIMER
M PREMKUMAR retweeted
Gastro-intestinal infections and stewardship practices—A call for action to practising GI professionals
Rohit Gupta et al
link.springer.com/article/10…
M PREMKUMAR retweeted
MUST-READ REVIEW
Gastrointestinal cancers in women: The role of sex hormones
by Amit Yadav &
Prof Usha Dutta @UshaPGIMER
#WomenGI #GItwitter
link.springer.com/article/10…
M PREMKUMAR retweeted
On the occasion of International Women's Day
We released the special issue of @IJG_Journal on women and gastroenterology.
It is purple to signify women empowerment
#GITwitter #WomensDayEveryDay
M PREMKUMAR retweeted
🆕 @INASL_Liver Consensus provides practical guidance on “difficult-to-treat AIH”
🔹 Acute AIH
🔹 Cirrhosis
🔹 Overlap syndromes & drug-induced AIH
🔹 Pregnancy, paediatric & post-LT AIH, comorbidities
📖 Read now in JCEH jcehepatology.com/article/S0…
M PREMKUMAR retweeted
Recompensation in ALD-20% (large multicenter data from India)
✅higher in DC without AAH
✅Linked to better survival
Each additional month of abstinence -3% higher chance of recomp.
7% re-decomp
17% decomp further (who did not recomp first)
ghadvances.org/article/S2772…
@BavenoCoop @ReibergerThomas @JimmyLaiCT @RoyAHep @ggarciatsao @ebtapper @juanpabloarab @TCotterMD #LiverX
M PREMKUMAR retweeted
💬 In cirrhotic patients with #HCC, how do you approach thrombotic risk assessment?
🔘 Routine screening
🔘 Case-by-case
🔘 Mainly after PVT occurs
🔘 No standardized approach
#LiverCancer #Hepatology
@manhalizzy @rav7ks @MichaelAlbertMD @docMPK @perillo_prazole @katiewiskar
🩸 This review highlights the burden of local and systemic thrombosis in #cirrhotic patients with #hepatocellular carcinoma, with a focus on portal vein thrombosis and its impact on treatment eligibility and outcomes.
🔗 [f.oaes.cc/xmlpdf/e4766416-3c…]
M PREMKUMAR retweeted
The Pancreas edition of @IJG_Journal is out !!
A wonderful compilation of articles!
M PREMKUMAR retweeted
Challenges and solutions for women in gastroenterology practice: From training to leadership roles
Sweta Rose @docMPK @drvishal82 @ShubhraMishra91
DrMakharia DrMatthew DrUsha
link.springer.com/article/10…
M PREMKUMAR retweeted
Non-selective beta blockers are well tolerated in pregnancy with portal hypertension
Team @cmcvelloreoff
link.springer.com/article/10…
M PREMKUMAR retweeted
Abstract Submission ➕ Registrations Now Open 📂
bls2026.com/
@ajay_duseja
@AnandVKulkarni2 @docMPK @drnipunverma @drsuniltaneja @DrKaushalMadan1 @doc_arka @DrAshish_Kumar @kumarrahul0204 @ebtapper @JasmohanBajaj @RajivJalan1 @DrHuangDQ @RobertFontanaMD
🪔On this auspicious occasion of Diwali
We are thrilled to announce the Bengal Liver Summit 2026!
📅 8–10 January 2026
📍 ITC Royal Bengal, Kolkata
🎯 Theme: Acute Complications in Liver Disease
🌍 12 International 🇮🇳 100+ National Faculties
Stay tuned for more updates!
#BLS2026
M PREMKUMAR retweeted
👨⚕️ @AnandVKulkarni2 et al. reported that of the 156 patients with Wilson disease, pediatric patients more often presented as ALF/ACLF with lower TFS than adults. 54% of patients had pathogenic/likely pathogenic ATP7B variants.
🔗 ow.ly/YTUp50Xm89W
🏷️ #GITwitter #GIX
M PREMKUMAR retweeted
Stigma & fatigue remain less commonly addressed issues in managing patients with IBD...Check out articles addressing the same with @DrAnuraagJ @drpreetamnath @drvishal82 @AKSHAYK49225783 @hsid_h
Stigma in IBD: onlinelibrary.wiley.com/doi/…
Fatigue in IBD: dx.doi.org/10.4291/wjgp.v16.…
