@dnusinow

Computational biologist @InterlineTx . Proteomics, Mass Spectrometry, and Systems Biology. R, Debian, and Free Software fanboy. https://xitter.cf/t.co/1UOU5fldpx

 Boston, MA
Joined April 2007
  • Tweets4.2K
  • Following748
  • Followers730
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We are excited to share our analysis of over 2000 #colorectal #cancer whole #genomes from @GenomicsEngland A great collaboration with @davidcwedge @group_tomlinson @trevoragraham @AndreaSottoriva amongst many others 🧵 1/9 biorxiv.org/content/10.1101/…

Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes...

To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution map to date of somatic...

biorxiv.org
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🫡 See you on the flipside mastodon.social/@dnusinow

David Nusinow (@[email protected])

148 Posts, 167 Following, 133 Followers · Dad, computational biologist, proteomics, Free Software, and video games. I’m gravity in a lot of places

mastodon.social
Thrilled to share our lab’s first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal. cell.com/cell-genomics/fullt…
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Research led by @utswcancer's @joshuagruber finds that talazoparib shrank tumors of breast cancer patients with mutations in the PALB2 gene. Nice work, Josh utsouthwestern.edu/newsroom/…

Breast cancer drug benefits broader group of patients, trial shows

A drug approved to treat breast cancer patients with mutations in the BRCA1 or BRCA2 genes may also benefit people who have other genetic mutations.

utsouthwestern.edu
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Artem Lomakin@LomakinAI9 Nov 2022
From sequencing and evolutionary theory we know that tumours grow as mosaics of clones - but so far we haven’t been able to see them. The labs of @Yates_lab, @MatsNilssonLab and @MoritzGerstung created a new method to map the spatial evolution of cancers: nature.com/articles/s41586-0…
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Devin Schweppe@dschweppe18 Nov 2022
Excited that this is out now! Thanks to @MolecularCell for including me in the `Introducing new group leaders` series! For more on our work, checkout out: schweppelab.org/ cell.com/molecular-cell/full…

Schweppe Lab

Research

schweppelab.org
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Mastodon is interesting for a lot of reasons. It doesn’t feel like a real Twitter replacement but I don’t have a strong sense of what it’s really excellent for yet either. Something in between Discord/Slack/IRC and twitter somehow
It me
Justin Meyer@justinrmeyer5 Nov 2022
Joined mastodon, picked a server, was reminded that I do interdisciplinary research and this is not going to work.
Cosmically stupid or historically malicious? It's the unanswered, constantly repeating question of our time.
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Horse ebooks@Horse_ebooks28 Jun 2012
Everything happens so much
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Ed Huttlin@EdHuttlin4 Nov 2022
After watching this project come together for a while, it's great to see this out in print. Congratulations to @echouchani, @HaopengXiao, and the rest of the authors on their hard work!
Ed Chouchani@echouchani4 Nov 2022
OPABAT is out today in @CellCellPress! We developed a proteomic approach for outbred mice to: 1) Nominate co-operative functions for thousands of understudied proteins. 2) Identify conserved regulators of physiology in brown adipose tissue. A thread: cell.com/cell/fulltext/S0092…

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

A mass spectrometry and network analysis approach that leverages the natural genetic, proteomic, and phenotypic diversity found in outbred populations to annotate the functions of thousands of...

cell.com
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Mol Syst Biol@MolSystBiol3 Nov 2022
#Metabolomics & computational analysis of 180 #cancer cell lines grown under the same condition identifies two major metabolic types ➡️ bit.ly/3fAsb9t @_nicola_zamboni @IMSB_ETH #metabolicflux
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A big one. I've been saying for a decade: "This is biology's century." And we're still not ready. My editors asked me to explain what that means. It was harder than I expected. I hope you like reading it. statnews.com/2022/11/03/why-…

Here’s why we’re not prepared for the next wave of biotech innovation

This is "biology's century," @matthewherper writes. But we’re approaching a moment when changes in what we understand are every bit as terrifying as exhilarating.

statnews.com
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JNCI@JNCI_Now29 Sep 2022
Now in @JNCI_Now, Dr. Anthony T Nguyen, MD, PhD and team conduct a pan-#cancer analysis across 16 common solid tumors and find that number of positive lymph nodes is a dominant and universal predictor of mortality. Read the study here: bit.ly/3OWJyhi
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Gwen@DataGwen28 Sep 2022
babe are you ok? you’ve barely touched the dashboard you claimed was mission critical
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nature
@Nature21 Sep 2022
Nature research paper: Antibody targeting of E3 ubiquitin ligases for receptor degradation nature.com/articles/s41586-0…

Antibody targeting of E3 ubiquitin ligases for receptor degradation

Nature - Membrane-bound E3 ubiquitin ligases RNF43 and ZNRF3 are overexpressed in colorectal cancer, and can be repurposed using proteolysis-targeting antibodies (PROTABs) to selectively degrade...

nature.com
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BIOS@bios_community19 Sep 2022
Builders 🧱 w/ Zach Sweeney - Co-Founder & CEO @ Interline Therapeutics Thanks @ZacharyKSweeney for sharing your story building @InterlineTx! See our episode below... ow.ly/qwWG50KMvqh
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Most ML interpretation methods have a common enemy: Correlated features. They ruin interpretation both on a technical and a philosophical level. Why correlation is problematic, how to patch it, and why we have no cure. A thread 🧵
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