@dcmadoff

Interventional Oncologist; Vice Chair for Clinical Research @YaleRadiology, Section Chief @Yale_IR, Yale School of Medicine

New Haven, CT
Joined October 2015
Interventional Oncology as the Fourth Pillar of Cancer Care: Essential Role in Gastrointestinal Cancer Management gicasym.org/interventional-o…
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Hot off the press! Our new review, “Locoregional therapies for intrahepatic cholangiocarcinoma: a stage-stratified, biology-informed multidisciplinary framework,” is now published in Chinese Clinical Oncology. Jonathan Tefera and I review the evolving role of locoregional therapies in the management of intrahepatic cholangiocarcinoma (iCCA), including future liver remnant augmentation, ablation, TACE, TARE, hepatic arterial infusion chemotherapy, and SBRT. Importantly, we discuss how these therapies can be integrated with surgery and modern systemic therapies across the disease continuum. As treatment options for iCCA continue to expand, multidisciplinary patient selection and appropriate sequencing of locoregional and systemic therapies will become increasingly important. The full article can be found at cco.amegroups.org/article/vi… #InterventionalOncology #InterventionalRadiology #Cholangiocarcinoma #LiverCancer #Oncology #Radiology @jomi9601 @YaleRadiology @Yale_IR @YaleIMed @YaleSurgery @YaleMed @YaleCancer @SmilowCancer @SIRspecialists @SIO_Central @cirsesociety @ECIOcongress @ISMIO_official @curecc @AASLDtweets @EASLnews @AHPBA
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Hot off the press in Current Oncology Reports! As the Interventional Oncology Section Editor, I am pleased to share our latest review, “Role of Interventional Oncology in the Management of Neuroendocrine Tumors: 2026 Update,” by Daniel DePietro and @michaelsoulen. The management of neuroendocrine tumor liver metastases continues to evolve, with liver-directed therapies playing an important role as systemic treatment options expand. This timely review examines recent advances in embolization, radioembolization, and ablation, as well as treatment sequencing, novel technologies, and the emerging role of biopsy and molecular profiling. An important theme is the increasingly integrated role of interventional oncology within multidisciplinary NET care, not simply as an isolated treatment, but as part of a longitudinal treatment strategy. Congratulations to Dan and Mike on this excellent and timely contribution! The full article can be found at link.springer.com/article/10… #InterventionalOncology #InterventionalRadiology #NeuroendocrineTumors #LiverMetastases #Embolization #Radioembolization #Ablation @SIO_Central @SIRspecialists @SIRRFS @SIR_ECS @cirsesociety @ECIOcongress @NANETS1 @ENETS_ORG @Penn_IR @PennRadiology
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Please join us for our upcoming Advancing Care in Liver Cancer: Surveillance, Team-Based Care, and Emerging Therapies — A Patient and Community Symposium on Saturday, October 17 at Yale. This program will bring together patients, families, members of the community, and experts from across our multidisciplinary liver cancer team to discuss surveillance and early detection, liver-directed therapies, transplantation, emerging treatments and clinical trials, and survivorship. I will be speaking about integrating liver-directed therapies into multidisciplinary liver cancer care and will also moderate a discussion focused on collaborating with our patients to improve care. The multidisciplinary approach is particularly important in liver cancer, where patients may benefit from a number of different treatment options throughout the course of their care. I look forward to what should be a very informative and interactive program. Saturday, October 17 | 9:00 AM–2:00 PM The Greenberg Center | 391 Prospect Street, New Haven #LiverCancer #InterventionalOncology #MultidisciplinaryCare #CancerCare #YaleCancerCenter @YaleMed @YaleRadiology @Yale_IR @YaleIMed @YaleDigestive @YaleLiverCancer @YaleSurgery @YaleCancer @SmilowCancer @MarioStrazzabos @sundar__raghav @JakabSimona
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Can we predict how well a liver will regenerate before liver venous embolization? Pleased to share our latest work from the Yale Interventional Oncology Research Lab, now published in the @JVIRmedia entitled “CT Radiomics to Predict Regenerative Biomarker Expression after Liver Venous Embolization: Proof-of-Concept in a Porcine Model.” We evaluated liver regeneration following venous embolization in both healthy and cirrhotic livers and asked whether baseline CT radiomics could provide insight into the underlying biologic regenerative response. Combined portal and hepatic vein embolization (PVE + HVE) produced greater angiogenic activity than PVE alone. Importantly, baseline CT radiomics showed promise for predicting regenerative biomarker expression, with the strongest performance for Ki-67 (AUC 0.84). This is proof-of-concept work, but I believe the direction is important: moving beyond measuring liver growth after embolization toward predicting regenerative potential before treatment. Congratulations to Jana Nguyenová, who led this work, and to Junlin Yang, Xuchen Zhang, @LShewarega, @jomi9601, @ResearchTomKuhn, Bernhard Gebauer, Lynn Savic, and @JuliusChapiro for their outstanding contributions to this collaborative effort. Article can be found at jvir.org/article/S1051-0443(… #InterventionalRadiology #InterventionalOncology #HepaticAugmentation #LiverRegeneration #Radiomics #ArtificialIntelligence #PVE @YaleRadiology @Yale_IR @YaleIMed @YaleSurgery @YaleMed @YaleCancer @ChariteBerlin @SIRspecialists @SIR_ECS @SIRRFS
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impact on ARRT and the profession. Wishing you all the best in your next chapter! 2/2
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Thank you! It was truly a privilege to serve on the @TheOfficialARRT Board of Trustees for the past eight years. I am incredibly grateful for the opportunity, the people I had the chance to work with, and the many friendships made along the way. I look forward to staying connected with the ARRT community!
Replying to @dcmadoff
On behalf of everyone at ARRT, thank you for eight years of dedicated service on the ARRT Board of Trustees, David! We are incredibly grateful for the time commitment, expertise, and leadership you brought to this volunteer role. Your contributions have made a meaningful 1/2
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I can’t believe my time on the @TheOfficialARRT Board of Trustees has come to an end. The past eight years truly flew by. It has been an honor and a privilege to serve on the Board alongside such a dedicated group of people. With more than 370,000 credentialed professionals, the work of ARRT is incredibly important. Throughout my time on the Board, I gained an even greater appreciation for the role ARRT plays in establishing professional standards, promoting quality and safety, and ultimately serving patients and the public. I am very proud of what we accomplished together and thankful to have had the opportunity to contribute. I am also grateful for the many colleagues and friendships that came from my time on the Board. Thank you to everyone at ARRT and to my fellow Trustees!
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I am looking forward to participating in the upcoming @SIO_Central Resident and Medical Student Section (RMSS) Journal Club on liver venous deprivation (LVD). We'll review the evolution of hepatic augmentation strategies, the rationale and technical approach behind combined portal and hepatic vein embolization (PVE/HVE), and the clinical evidence supporting liver venous deprivation, including the DRAGON-1 study. We'll also discuss the design and rationale of the ongoing DRAGON-2 trial, as well as the role of LVD in optimizing the future liver remnant before major hepatic resection. I hope to see you there on August 13! @Yale_IR @YaleRadiology @YaleMed @YaleCancer @SmilowCancer @YaleIMed @YaleSurgery
Join the next RMSS Journal Club to explore the evolving role of liver venous deprivation (LVD) and how combined portal and hepatic vein embolization (PVE/HVE) may enhance future liver remnant growth compared with traditional PVE. Register: bit.ly/3Rtf9Lv
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It was a pleasure joining Dr. @JMichaelBarraza on the @_backtable podcast to discuss portal vein embolization & its evolving role in expanding the boundaries of liver tumor resectability. We discussed the physiological basis of PVE, technical considerations, patient selection, and emerging approaches to optimize future liver remnant function before major hepatic resection. I hope the conversation is helpful to those involved in the multidisciplinary care of patients with liver tumors. Thank you for the invitation. @Yale_IR @YaleRadiology @YaleMed @YaleCancer @YaleIMed @YaleSurgery @SIRspecialists @SIO_Central @cirsesociety @ECIOcongress @ISMIO_official @AASLDtweets @EASLnews @IHPBA
How is portal vein embolization pushing the boundaries of liver tumor resectability, and what does it take to induce hypertrophy without compromising the remnant liver? In this episode, interventional radiologist Dr. David Madoff (@dcmadoff) of @Yale_IR joins Dr. Michael Barraza (@JMichaelBarraza) to discuss the pathophysiological rationale, technical considerations, and emerging clinical paradigms of performing PVE to augment the future liver remnant prior to resection and reduce the risk of postoperative liver failure. 🎧 Tune in to the episode on the BackTable app → na2.hubs.ly/H06t32-0 #VI660 #InterventionalRadiology #IRad #RadTwitter #PortalVeinEmbolization #LiverSurgery #MedEd
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Great time spent with Professor Jens Vogel-Claussen. Enjoyed our time together and very interesting lecture. Thanks @JuliusChapiro for inviting me to participate in the festivities!
It was truly great to welcome Professor Dr. Jens Vogel-Claussen, my colleague, friend and brand new Chariman of the Department of Radiology @ChariteBerlin to @YaleRadiology for a Grand Round Lecture. Our partnership continues to grow, with the Rising Star Exchange and other deep scientific ties being of tremendous mutual importance. Both of our stories began at @Hopkins_Rad ! Amazing to see him elevate all of @ChariteBerlin globally! They are so lucky to have him and we were lucky to welcome him to teach our residents and faculty on his outstanding work on Lung Cancer Screening in Germany! Thank you @Mahan_Mathur @dcmadoff @CsFuss @fabianmaxlg for your help and your time and the support to organize this! Thank you also to our fabulous educational team and to the @YaleRadRes who impressed our guest with expert knowledge and totally mastered the case review! ❤️🙏🏻
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Agree with @JuliusChapiro! We have excellent programs in clinical #irad as well as in research and education!
Our @Yale_IR section at the Yale School of Medicine is seeking outstanding faculty candidates to join one of the nation’s premier academic IR programs. Opportunities include: 🔹 Clinical excellence across a high-volume tertiary referral network 🔹 Dedicated research and innovation support 🔹 IR residency education and mentorship and global health @Road2IR 🔹 Multidisciplinary collaboration in vascular disease, pediatric IR, vascular malformations, transplant, trauma, complex venous disease, PAD, VTE, oncology, pain therapy Very competitive compensation & great benefits. We expect excellent applicants from early-mid to senior career stages. Join a growing team of 15 faculty shaping the future of IR DM for details! #InterventionalRadiology #IRad #AcademicMedicine #YaleMedicine #PhysicianJobs #Radiology #MedTwitter
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Amazing first day of the Ibero-American Society of Interventional Radiology (SIDI) Congress in Medellín, Colombia! My lecture was on technological advances in liver tumor management during the morning session on #interventionaloncology! Many thanks to Dr. Micaela Arrieta, Dr. Ethel Rivas Zuleta and Dr. Pilar Bayona for your kind invitation! #irad @YaleMed @YaleRadiology @Yale_IR @YaleCancer @YaleIMed @YaleSurgery
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David C. Madoff, MD retweeted
Thank you very much @dcmadoff for your continuous support. It is my honor and pleasure to be part of such a supportive and strong Yale International Oncology team! @JuliusChapiro @Yale_IR @YaleMed @YaleRadiology @ChariteBerlin #irad #interventionaloncology #Radiology
Awesome work @SaraAbosabie! All of us at the Yale Interventional Oncology Research Lab are so proud of you! Congratulations! #irad #interventionaloncology #radiology @YaleMed @Yale_IR @YaleRadiology @YaleIMed @YaleCancer @ChariteBerlin
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Awesome work @SaraAbosabie! All of us at the Yale Interventional Oncology Research Lab are so proud of you! Congratulations! #irad #interventionaloncology #radiology @YaleMed @Yale_IR @YaleRadiology @YaleIMed @YaleCancer @ChariteBerlin
Thankful to be featured on the official @ChariteBerlin Instagram page as a young MD/PhD candidate and researcher. I am very grateful for the support of my amazing mentors, Dr. Lynn Savic, @JuliusChapiro @dcmadoff @Yale_IR @YaleRadiology @YaleMed Video: instagram.com/reel/DKHmpmFMH…
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David C. Madoff, MD retweeted
The @Yale_IR #IOlab graduated yet another class! Off to your amazing adventures. Strong work. Keep working hard! There is no substitute for hard work. It always pays off. Bright future ahead! @ChariteBerlin
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David C. Madoff, MD retweeted
Whenever I do a really complex case in a rare pathology and succeed, I walk out thankful for the amazing training I had during residency. I can’t imagine a better place to train than among the giants of @Yale_IR ! This is truly the place to be. I periodically have my mentors return to me in spirit during the case, and whisper words of wisdom to me, in their own voices. Am I the only IR who keeps hearing voices? @SIRspecialists #NotParanoid #Thankful
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David C. Madoff, MD retweeted
I would like to recognize and thank @bostonsci @bsc_io @bsc_pi for 8 years of continued support with an instrument grant for Cryoablation, giving us the opportunity to study cryoablation on 2 @NIH funded grants and to publish it in high impact journals like @radiology_rsna and J Hep. This investment meant a lot for us and continues to support our deepening understanding of immunological microenvironments around HCC.
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The @Yale_IR #IOLab is definitely firing on all cylinders!!! Looking forward to more interesting research and publications in the near future!
We have 2 more major blockbusters coming out soon from the lab in addition to the Radiology and J Hep papers published in the last 12 months. This NIH RO1 will end with a nice firework of papers. If it ever gets renewed a third time, it will not be for the lack of hard work that the students and post-docs put in. Everyone is working very very hard. This is truly not for the weak. The lab is known for iron clad discipline, long hours, but also lots of fun and passion. @Yale_IR #IOlab is the Top Gun.
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Such a great team! Truly enjoying working with all of you!
Updated @Yale_IR #IO lab pic Regrets from @LShewarega and who was on clinical service! Patient care first!
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