Scientist (chromatin, epigenetics, repetitive elements, brain development). British male human living in Sweden. Views are my own.
Malmö (home) and Lund (work)
Joined January 2012
- Tweets1.4K
- Following346
- Followers540
- Likes2.4K
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
Christopher Douse retweeted
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. nature.com/articles/s41467-0…
Christopher Douse retweeted
📰 A recent @NatureComms study by a @Lund_Stem team led by @ch_douse reveals how DNA methylation & the HUSH complex work to silence repetitive #DNA and protect genomic stability, providing new insights for #aging and disease research.
Read more ⤵️
stemcellcenter.lu.se/article…
Cool study!
The research project that got the lab off the ground has been published in @NatureSMB 🥹. I couldn't do a better job of summarizing than co-lead author @jrichardalbert , so he'll take it from here! (and makes unexpected connections with our other recent study)
Christopher Douse retweeted
#RepeatExpansionDisorders are up to three times more common than current estimates. Underdiagnosis or reduced penetrance?
by our wonderful dream team @kriski_ibanez @mattzano @chrsclrksn + Bharati Jadhav & Andy Sharp
nature.com/articles/s41591-0…
Christopher Douse retweeted
New research from the Krabbe lab!
We used deep-brain imaging at the single cell level to show that amygdala interneurons are highly plastic across fear learning and extinction at both the ensemble and single neuron level.
biorxiv.org/content/10.1101/…
Christopher Douse retweeted
An exciting advance in Type 1 diabetes
First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it!
@CellCellPress
sciencedirect.com/science/ar…
@Nature
nature.com/articles/d41586-0…
Christopher Douse retweeted
Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation.
Congratulation to all the authors!
nature.com/articles/s41586-0…
This is awesome 👇
🚨Preprint alert🚨 Excited to share the #preprint version of our work @MundlosLab ! Curious about how a transposable element (TE) insertion can cause developmental phenotypes? 🧬🦠🐁
Check the 🧵 below and the full version on BiorXiv:
biorxiv.org/content/10.1101/…
This is such an honour! Thanks @RBerrens :)
This Post is from an account that no longer exists. Learn more
Delighted that this is finally out! Thanks to @Faulkner_Lab @todd_macfarlan and the other reviewer for good and constructive comments that arrived in my inbox the day after my second child was born... paper here nature.com/articles/s41467-0…. Short reflection on new stuff...
Happy and proud to share my lab’s study on how DNA methylation and the HUSH-MORC2 corepressor work together, out last week on biorxiv: biorxiv.org/content/10.1101/…
A fantastic collaboration with our colleagues at @JakobssonLab @Lund_Stem...1/7
We also think that our findings explain conflicting prior work on HUSH-MORC2-mediated retrotransposon restriction i.e. that the methylation status of the genome in general, and individual L1/transposon integrants in particular, is critical in defining sensitivity to this complex.
Christopher Douse retweeted
Happy to share my co-1st author paper in @Nature on how the immune system adapts during gender-affirming hormone therapy with testosterone treatment (1/15)
nature.com/articles/s41586-0…
Really excited to read this - I so loved the MORC3 study. Congratulations to all the authors!!
This Post is from an account that no longer exists. Learn more
Christopher Douse retweeted
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine.
science.org/doi/10.1126/scie…
Here is a summary of what we discovered!
Christopher Douse retweeted
🚨 Big news! My first first-author paper is now published in Science! 🎉 So grateful to all co-authors, collaborators and funders for their big support! 🙏
Check out the study here: science.org/doi/10.1126/scie…
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine.
science.org/doi/10.1126/scie…
Here is a summary of what we discovered!