Professor, University of Queensland. Retrotransposons and genomics. Views my own. Scholar publications: https://xitter.cf/t.co/xQu0hWudj1 @faulknerlab.bsky.social
Brisbane, Queensland
Joined July 2017
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After years of telling visitors to Brisbane what an awesome place it is for fun* adventures, I've decided to make a list in the order I remember them of my favourite places to go for ease of reference. Here goes ...
(*definition of fun may vary)
I wrote peer review comments for a recent bioRxiv preprint from the SMaHT consortium @SMaHTnetwork
hyp.is/YZCCeKp1EfGbxutkqUxjK…
Consortium is a $140M USD @NIH Common Fund initiative to deeply sequence human tissues. I hope the comments, mainly on the mobile DNA part, are useful.
Our study published today @ScienceMagazine shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome:
doi.org/10.1126/science.adz8…
With outstanding Perspective from Aurelien Doucet & @retrogenomics:
doi.org/10.1126/science.aej3…
Credit to all the authors, particularly co-first authors Jose de los Rios Barreda, @eugeniaferreiro, @tashjansz, @charles_bell92, and co-senior author John Moran, and thanks to the reviewers for writing thoughtful and reasonable critiques. I'll write a more detailed 🧵soon.
Reposting comment on preprint of this @Dev_Cell paper. Stats done on technical replicates of L1 KD to make small absolute changes seem significant. Biological replicates were available but not used for stats, why? Because p>0.05? I don't understand this.
sciencedirect.com/science/ar…
I doubt the stated phenotype here is due to changes in L1 mRNA. The ASO and CRISPRi KD approaches (Figs 1, S1, S2) reduce L1 expression by <10% and these small changes are noted as efficient and significant KD. Stats were done on tech reps to give p<0.05
biorxiv.org/content/10.1101/…
Geoff Faulkner retweeted
1/ Our lab’s first preprint found a wonderful journal home! 🎉
Our paper explores the role of testis-specific transcription factors in Drosophila and reveals broad functional connections between tissue-specific paralog proteins.
📝: genesdev.cshlp.org/content/e…
Thoughtful and rigorous work from @RippeiH and @PRAndersen teams looking at PAF1C and transcriptional termination. Interesting for me to look at "the other end" of transcription for a change. I wonder what brings tTAF and tPAF together?
genesdev.cshlp.org/content/e…
Geoff Faulkner retweeted
🚀 Join the CRG as a Junior Group Leader in Quantitative Cell Biology! 🧬
We’re seeking passionate leaders to tackle fundamental biological questions using cutting-edge multidisciplinary approaches. Enjoy generous core funding, state-of-the-art facilities, and a collaborative environment.
📅Apply by Oct 15!
ℹ️Details: ow.ly/aACB50TzKM2 #CRG
Geoff Faulkner retweeted
The 5-year postdoc position in my lab is now "live" for applications! Deadline to apply is November 3rd: imperial.ac.uk/jobs/search-j…
Please RT
I doubt the stated phenotype here is due to changes in L1 mRNA. The ASO and CRISPRi KD approaches (Figs 1, S1, S2) reduce L1 expression by <10% and these small changes are noted as efficient and significant KD. Stats were done on tech reps to give p<0.05
biorxiv.org/content/10.1101/…
Geoff Faulkner retweeted
I am looking for a motivated PhD student who is interested in understanding the fundamentals of gene regulation. They will be working directly with me on a DECRA funded project (scholarship guaranteed for domestic students). DM me if you know of anyone interested, including you
Geoff Faulkner retweeted
interested in 3D genome organization during early development? want to understand how it is shaped by RNA? you like data analysis and developing new computational tools? 🧬💻🧐
With @golobor we are recruiting a PhD student/intern to work with us at @IMBA_Vienna
Congrats @JuanManuelBotto for passing your final PhD milestone and welcome to the lab @barunlz !
Geoff Faulkner retweeted
Delighted that this is finally out! Thanks to @Faulkner_Lab @todd_macfarlan and the other reviewer for good and constructive comments that arrived in my inbox the day after my second child was born... paper here nature.com/articles/s41467-0…. Short reflection on new stuff...
Happy and proud to share my lab’s study on how DNA methylation and the HUSH-MORC2 corepressor work together, out last week on biorxiv: biorxiv.org/content/10.1101/…
A fantastic collaboration with our colleagues at @JakobssonLab @Lund_Stem...1/7
Geoff Faulkner retweeted
Calling all emerging scientists - it’s time to send us an application! 😉😎 Lead your own #MaxPlanck Research Group w/ €2.7M in funding over 6 yrs, full independence & resources to hire staff. State-of-the-art infrastructure awaits you!🌟 Apply today➡️mpg.de/career/max-planck-res…
Geoff Faulkner retweeted
Preprint on "BWT construction and search at the terabase scale". We can compress 100 human genomes to 11GB in 21 hours, find SMEMs with it, do affine-gap alignment and retrieve similar local haplotypes. 7.3Tb commonly sequenced bacterial genomes ⇒ 30GB arxiv.org/abs/2409.00613
Geoff Faulkner retweeted
Proud to have contributed to this fantastic study led by @ch_douse . HUSH for the world!
nature.com/articles/s41467-0…
Geoff Faulkner retweeted
1/11 Welcome to our August ECR spotlight! This month we get to know Charles Bell @charles_bell92 who works in the Faulkner lab @Faulkner_Lab at the Mater Research Institute @MaterResearch and University of Queensland.
Geoff Faulkner retweeted
Just under a week to apply to join our team working on the spatial transcriptomics (#MERSCOPE, #VisiumHD, #Xenium, and more..) of poor prognosis cancers.
external.jobs.uwa.edu.au/en/…
Geoff Faulkner retweeted
Please RT! 🧬🧬
I am looking for a #postdoc fellow to lead a new project in 3D chromatin organisation and transcriptional regulation in cancer (experimental and/or computational) at @SAiGENCI in Adelaide.
Apply below:
careers.adelaide.edu.au/cw/e…
This @CellCellPress paper reported rat RNLTR12-int ncRNAs influence myelination. I guessed an alternative explanation for what was found but after testing this I was wrong. I wanted to share what we did in case anyone else goes down the same path. 1/n
sciencedirect.com/science/ar…
Juan made a HEK293T line (where RNLTR12-int should be absent) stably expressing rat Mbp and introduced the RNLTR12-int siRNA, then used the published Mbp qPCR primers to evaluate the siRNA's effect on Mbp compared to a non-targeting siRNA. No significant effect was observed. 4/n
