Developmental Cancer Genomics. We study cancer and developmental biology using genomics and computing. PI @StAnna_CCRI | postdoc @CeMM_News | PhD @crm_edinburgh
Vienna, Austria
Joined March 2019
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Our latest paper on modeling the effects of #neuroblastoma mutations on #development using #stemcells is finally out in @NatureComms! Amazing collaboration with @a_tsakiridis! More info to follow, read the paper here: rdcu.be/dGLrQ
Florian Halbritter retweeted
Happy to share our last work on mitotic bookmarking where we describe a new role for extensively studied TFs. Heroic effort by first author Inma over many years. genesdev.cshlp.org/content/e…
Florian Halbritter retweeted
👩🔬👨💻Happy to share the latest paper from the lab, led by postdoc Ana Kutschat. We found that ARID5B - a factor associated with predisposition to pediatric leukemia, functions as a chromatin repressor recruiting HDACs on chromatin. 💊🔬🩸
🧬How inherited DNA changes increase childhood leukemia risk
A new study from CeMM Adjunct PI @DSeruggia's group at @StAnna_CCRI reveals how ARID5B guides immune cell development & how its loss may raise B-cell leukemia risk.
➡️ bit.ly/4xZO4CK
📄 bit.ly/43RSc9X
Florian Halbritter retweeted
Congrats to @ines_4412, PhD in our team, on her first first-author paper! 😉 #KRAS #TPD #PROTACs #LUAD #IRBBarcelona
A great collaboration with the Santamaría (@ciccancer) and Riera labs (@URSAchemlab, #IRB), among many other friends and colleagues!
Now online: Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis doi.org/10.1158/0008-5472.CA…
Florian Halbritter retweeted
🔬 At this year’s Long Night of Research, around 850 visitors joined us to experience the future of childhood cancer research. Through direct engagement, guests gained insight into how scientific ideas evolve into meaningful approaches for young patients!
Check out this work from Davide's lab!
🚨New paper! St. AnnaCCRI Researchers together with @CeMM_News uncovered a new strategy against leukemia: by collapsing the SAGA scaffold, the cancer-driving protein KAT2A breaks down, potentially halting leukemia cell growth. Published in @NatureComms👉shorturl.at/IWWwy
Florian Halbritter retweeted
Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s41586-0…
Florian Halbritter retweeted
New preprint from the lab!
How do tissue shapes influence cell fate decisions?
By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors.
biorxiv.org/content/10.64898…
1/
Florian Halbritter retweeted
Functional chromatin signatures premark future lineage-specific enhanc... sciencedirect.com/science/ar…
Florian Halbritter retweeted
🔍 Search a tissue image like a dataset?
CeMM PI André Rendeiro & team have developed #LazySlide, an AI-powered, open-source tool that links whole-slide pathology images to molecular data & enables natural-language search.
➡️ bit.ly/4jZWLGk
📄 bit.ly/4ujQZEq
Florian Halbritter retweeted
Integration of large, complex single-cell datasets with Harmony2 biorxiv.org/content/10.64898…
Florian Halbritter retweeted
👋We are hiring a computational PhD student, interested in functional genomics and the non-coding genome. To continue developing our BRAIN-MAGNET algorithm recently published in Cell (cell.com/cell/fulltext/S0092…). See vacancy for details!
werkenbijerasmusmc.nl/en/vac…
Florian Halbritter retweeted
CellDEEP: Cell DiffErential Expression by Pooling highlights issues in differential gene expression in scRNA-seq biorxiv.org/content/10.64898…
Florian Halbritter retweeted
Excited to share another recent paper from the lab, in collaboration with @lucapinello and @danielevanbauer. We leveraged allele distributions after dense editing to identify the regulatory potential of individual nucleotides within #enhancers:
nature.com/articles/s41467-0…
Florian Halbritter retweeted
INTERESTED IN SINGLE-CELL LINEAGE TRACING?
New review @NatureRevGenet from the @FraticelliLab. 🎉🎉
nature.com/articles/s41576-0…
With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY!
Read link: rdcu.be/e50gy
Florian Halbritter retweeted
Happy to share our paper in collaboration with the Halbritter group (@cancerbits). We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin!
👉 doi.org/10.1093/nar/gkag124
@StAnna_CCRI @CeMM_News
Our new paper is out! Read all about it in the post below:
📢 New paper alert!
A research team led by @cancerbits and @DSeruggia developed a new method that helps scientists craft more accurate cellular models from stem cells. More: ccri.at/guiding-stem-cells-s…
Florian Halbritter retweeted
📢 New paper alert!
A research team led by @cancerbits and @DSeruggia developed a new method that helps scientists craft more accurate cellular models from stem cells. More: ccri.at/guiding-stem-cells-s…
Florian Halbritter retweeted
In Focus: Raising Awareness of Tremendous Progress and Ongoing Challenges in the Fight against Childhood
and Adolescent Cancers brnw.ch/21x088m
By Samara L. Potter and Elaine R. Mardis at @nationwidekids @OhioStateMed
Florian Halbritter retweeted
🎗️#InternationalChildhoodCancerDay! Every year, around 400,000 children worldwide are diagnosed with cancer. Progress is possible: through research, international collaboration and close cooperation between science and clinical care. Read more: ccri.at/international-childh…
