@FraticelliLab

Quantitative Stem Cell Dynamics lab @IRBBarcelona led by @AlejoFraticelli stem cells | hematopoiesis | lineages | epigenetic memories Account run by students

 Barcelona
fraticellilab.com/
Joined December 2021
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  • Followers1.7K
33Media
Finally out in Nature our collaboration with the Velten Lab 🥰 Enjoy the reading! nature.com/articles/s41586-0…

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...

nature.com
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Fraticelli Lab retweeted
Maria Guarini@mguarini1
Sep 1
It was a pleasure to present our new technology at @ISEHSociety 2026 in Frankfurt ✨😍 It makes me really proud of my PhD journey! Thanks to all the @FraticelliLab to make it possible!💫
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Super proud of our postdoc @VictoriaParreno for receiving the prestigious Branco Weiss Fellowship 😍 She will explore how life events, such as pregnancies and menopause affect hematopoietic stem cells 👏✨💫 brancoweissfellowship.org/fe…

Victoria Parreno - The Branco Weiss Fellowship

brancoweissfellowship.org
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We are still recovering from yesterday’s emotions! Our very special @mlopezosias successfully defended her PhD 🔥🎓💕we are extremely proud of you and we hope all your wishes become true!! 🙌🏻Enhorabuena Dr.a Marta López-Osias!!
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We are still thinking about #ISCO2026 😍 It was super nice to host in Barcelona the single cell omics community! 👏 Great science and great vibes 💃
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🧬How do stem cells ‘think’? 👨‍🔬Tomorrow, @alejofraticelli @irbbarcelona @icreacommunity will be giving the seminar ‘Stem cells thinking: fast and slow’ as part of @hmar_research cancer series 📍Marull Room @hospitaldelmar 📅3/06 |🕑2.00 pm 👉researchmar.net/agenda/1093/ @fraticellilab
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Happy to share that members of our lab were part of this major story just published! Congratulations to all the authors!!🥳🥳 nature.com/articles/s41556-0…

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from...

Nature Cell Biology - Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying...

nature.com
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Fraticelli Lab retweeted
Mick Milsom@MilsomMick
May 25
How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @NatureCellBio Collab with @haas_lab @ChariteBerlin BIH & MDC; Thomas Höfer & Daniel Hübschmann @DKFZ @NCT_HD @hi_stem_lab 1st authors @Esther_RCorrea @FloGrunschlager & Tamar Nizharadze
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One of the most interesting studies on lineage fate plasticity I’ve seen in a while. This one is an instant must-read. Is there clonal memory? Yes of course. But the actual clonal outcome is heavily influenced by demand from the niche/feedback. (Glad our minor contribution was helpful!)
Mick Milsom@MilsomMick
May 25
How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @NatureCellBio Collab with @haas_lab @ChariteBerlin BIH & MDC; Thomas Höfer & Daniel Hübschmann @DKFZ @NCT_HD @hi_stem_lab 1st authors @Esther_RCorrea @FloGrunschlager & Tamar Nizharadze
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This is an amazing opportunity for pediatric hemato-oncology researchers. @EHA_Hematology @BloodCancer_Res @DFBC_PedCare @ISEHSociety @ASH_hematology @EHA_StemCells @Hemasphere_EHA @LeukemiaJnl @BloodPortfolio
Josep Carreras Leukaemia Research Institute (IJC)
@CarrerasIJC
Apr 27
🔬 We’re hiring 3 Group Leaders in Paediatric Haematologic Malignancies 🤝 @CarrerasIJC & @IRSJD_info are joining forces to launch a new translational research hub focused on paediatric blood cancers. 📝 Apply now to drive real change for young patients: careers.carrerasresearch.org… @SJDbarcelona_es @fcarreras
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Happy to celebrate the @IRBBarcelona 20th bday with such an amazing event! ☀️🫶🏻🎂
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Huge news from #EHARecon2026 in Finland! 🏆 Congrats Maria! 🥰👏 #EHA @EHA_Hematology
Maria Guarini@mguarini1
Mar 27
It was a pleasure to present for the first time my PhD project at the #EHAReCon26 in Finland. 🇫🇮 Extremely honoured to have received the best poster presentation award from the scientific committee. Really inspired and grateful to be part of such an amazing community☀️🤍
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Fantastic day hearing about all the super cool projects cooking at the @AlejoFraticelli lab. Such a creative group of people! – at Barcelona, Spain
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New GROUP LEADER POSITION announced @IRBBarcelona !!! This one is for CHEMICAL BIOLOGY 🧪! Chemists apply👩🏻‍🔬👨🏽‍🔬🧑🏻‍🔬!!!! recruitment.irbbarcelona.org…
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Victoria@VictoriaParreno
Feb 27
Interested in single-cell lineage tracing? 🧬 Our new Review in @NatureRevGenet updates the modern toolbox for genetic tracing and clonal analysis — from synthetic barcoding to natural genomic and epigenomic variants. Glad to have contributed alongside @AlejoFraticelli 🙌
Alejo Rodriguez-Fraticelli
@AlejoFraticelli
Feb 27
INTERESTED IN SINGLE-CELL LINEAGE TRACING? New review @NatureRevGenet from the @FraticelliLab. 🎉🎉 nature.com/articles/s41576-0… With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY! Read link: rdcu.be/e50gy

Charting single-cell lineages with synthetic and natural barcodes

Nature Reviews Genetics - In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as...

nature.com
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INTERESTED IN SINGLE-CELL LINEAGE TRACING? New review @NatureRevGenet from the @FraticelliLab. 🎉🎉 nature.com/articles/s41576-0… With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY! Read link: rdcu.be/e50gy

Charting single-cell lineages with synthetic and natural barcodes

Nature Reviews Genetics - In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as...

nature.com
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A nice good-morning with a new preprint from our lab!! 😍🥳 this was a real team effort💥 Hope you all enjoy the reading!
Alejo Rodriguez-Fraticelli
@AlejoFraticelli
Feb 26
🚨 NEW @FraticelliLab PREPRINT JUST WENT LIVE biorxiv.org/content/10.64898… Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!
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The Fraticellis started 2026 with great energy! 🥳 Our lab retreat of last week was full of fun, good vibes, heartfelt moments, and crazy late-night science discussions. 👀🩷 Batteries fully recharged!🔋
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2025 was an incredibly successful year for the Fraticelli Lab! We loved celebrating it together during our xmas day—especially with some wonderful new faces joining us.🥰 We’re excited for what 2026 will bring and wish everyone happy holidays! 🎄🎅💫
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Outstanding PhD fellowship call OPEN for excellent students. lacaixafoundation.org/en/doc… This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels). If you’re interested in doing a PhD in our lab @IRBBarcelona, reach out!!!!

Doctoral INPhINIT fellowships - Incoming Call 2026

We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

lacaixafoundation.org
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In addition, the main @IRBBarcelona PhD call is open right now! 👉 General call ➡️ bit.ly/3LtzIXi 👉 IRB DRIVE call ➡️ bit.ly/4hODx5B Come work on us - several cool possible projects in immunity, cancer and aging!!! Let’s trace some cells!
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