@biotaxis
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Bioengineering grad student at BU, BioBuilder educator, @OlinCollege alum. Synthetic biology, human-centered design, & fermented foods. He/him.
Boston, MA
Joined March 2016
- Tweets333
- Following828
- Followers405
- Likes6.2K
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This was an exciting project, and I am so glad we get to share it now!
Antibiotic resistance genes have been a core tool in synthetic biology since the start. In our new preprint by @biotaxis, we develop tools that will enable control over bacterial survival in space and time using light. 🦠💡
biorxiv.org/content/10.1101/…
Michael Sheets retweeted
An excellent contribution to the literature on SynBio education - congrats to the team @EngBioRC !
Introduction to Engineering Biology: A Conceptual Framework for Teaching Synthetic Biology | ACS Synthetic Biology pubs.acs.org/doi/10.1021/acs…
Michael Sheets retweeted
Minipreps! They're a fact of life. But if they don't bring you joy, you might want to try new tactics or treat yourself to some fun new toys!
Our lab has done 2,625 minipreps so far. Let me share a few tidbits about our approach and our favorite pieces of equipment. 🧵 (1/n)
Michael Sheets retweeted
On Thursday we had the pleasure of hosting the Tyngsboro High School's BioBuilderClub Team at our Learning Lab! While here, they performed a bacterial transformation with the DNA plasmid they designed. Great work from these amazing students! #tpsprepares #biobuilder
Michael Sheets retweeted
Our latest paper is out! Light-inducible expression of antibiotic resistance genes. Led by @biotaxis, with help from @NathanTague2. Constructs are on @Addgene if you want to try them out.
And to wrap up today's paperfest, @biotaxis and co in the @DunlopLab at @BostonU_BME present an optogenetic toolkit for light induced antibiotic resistance
go.nature.com/41AGRJd
Excited to share my latest work! We use light to turn on antibiotic resistance, and can use this to boost fatty acid bioproduction.
And to wrap up today's paperfest, @biotaxis and co in the @DunlopLab at @BostonU_BME present an optogenetic toolkit for light induced antibiotic resistance
go.nature.com/41AGRJd
Michael Sheets retweeted
Delighted to share our latest paper on the RENDR platform — an engineered ribozyme that can convert RNA signals into orthogonal protein outputs. Published in @NatureComms and led by @laurgamb, @AOStaubus, @Kimwai_Mo, and @andrea_faint. Supported by @NSF
nature.com/articles/s41467-0…
Michael Sheets retweeted
We are now accepting applications for the 2023 Apprentice Challenge Class! BioBuilder's 8 Week program for Boston area high schoolers that prepares students for summer internships at area academic labs and life science companies.
biobuilder.org/program/high-…
Michael Sheets retweeted
Interested in bacterial peptide sensing? Check out my latest paper! Thanks to all of my amazing co-authors in
@LabTabor lab + beyond: @synthetic_queer Andrew Mu @KGroszman @KyVanHoang @kevin_lorch @bhpogostin @DrGunn43 @jeffrey_j_tabor nature.com/articles/s41589-0…
Michael Sheets retweeted
Join the EBRC SPA December 6 for Data and Engineering: Operating at the Technical Interface. Panelists will discuss transitioning to industry, their current role, and valuable data-specific skills. Learn more and register here: ebrc.org/ebrc-spa-presents-d…
Michael Sheets retweeted
Super excited that our paper with @ajofranklinlab, i.e., CAF, is out (doi.org/10.1038/s41586-022-0…) with @meeeeechigan, @su2lin_SEU, Xu Zhang, and George Bennett. Congrats to all!!!
Michael Sheets retweeted
Very excited to share our new preprint where we use a deep learning-based feedback algorithm to control gene expression in real time in thousands of single E. coli cells in parallel. This work was led by @jblugagne and @cblassick. 1/
I learned so much through making these slides, and I hope they'll help you learn (and teach) too! Very excited to share a new course module that covers the theory, core tools, and impacts of engineering/synthetic biology: ebrc.org/ed-module-introduct…
Looking to teach #engineeringbiology in your course? EBRC is excited to announce a new resource! Our modular slide deck on the impacts and principles of Engineering Biology, by Michael Sheets @biotaxis and Josh Atkinson @meeeeechigan: ebrc.org/ed-module-introduct…
Michael Sheets retweeted
Here's our new article -- potentially, everything you ever wanted to know about light-regulated gene expression in bacteria (& much more).
frontiersin.org/articles/10.…
Welcome opportunity to team up once again with @RobertOhlendorf (this guy knows stuff!). Enjoy
Michael Sheets retweeted
What if you could image 🔬cells and then choose which ones to sequence 🧬?
What if you could go back and image 🔬cells that you previously sequenced 🧬?
Now you can 🔬 then 🧬 then 🔬 cells again with Light-Seq!
nature.com/articles/s41592-0…
Let’s dig in 🧵.
Michael Sheets retweeted
Genome sequencing of the evolved populations revealed why resistance accelerated in MS but not in SS: mildly-selected resistance mutations were stably maintained without selection, contrarily to strongly-selected mutants that were unstable in drug-free environments.
4/5
Michael Sheets retweeted
REVIEW: Deep Learning Concepts and Applications for Synthetic Biology
@DunlopLab and colleagues present an overview of #SynBio relevant classes of data and #DeepLearning architectures and discuss the challenges and future opportunities in this space.
liebertpub.com/doi/10.1089/g…
Michael Sheets retweeted
I am pleased to release the @EngBioRC “Synthetic Biology and Machine Learning” education module. In it I talk with synbio/ML researchers about projects in their groups and ideas for how to learn more about this space.
ebrc.org/synbio-ml-education…
Michael Sheets retweeted
BREAKING: The Supreme Court just reversed nearly 50 years of precedent and overturned Roe v. Wade, ending the federal constitutional right to abortion.
We won't deny what a horrible moment this is.
Half of the states are expected to ban abortion.
Michael Sheets retweeted
What an amazing meeting #bostonbacterial22 has been! We would like to thank, our 2022 co-chairs @ssespinozam and @Jenna_Wurster, the organizing committee, and all of our attendees for creating a wonderful & engaging environment for science! THANK YOU!