I tweet about genome assembly and related topics. If something happens in the world of genome assembly and I don’t tweet about it…then it didn’t really happen.
London, England
Joined November 2010
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The Assemblathon retweeted
Does anyone have recommendations on programs for genome alignment and synteny analysis? #pacbio #genomealignment #synteny #assembly #genomeassembly @assemblathon
The Assemblathon retweeted
So proud and excited for our #T2T work on "A complete reference genome improves analysis of human genetic variation"! Im enormously grateful to the whole team for their tireless work and support @JHU_BDPs @JHUCompSci @HopkinsCMDB science.org/doi/10.1126/scie…
The Assemblathon retweeted
The End of the Beginning of Human Genome Sequencing? Quick thoughts on today's #T2T publishing barrage omicsomics.blogspot.com/2022…
The Assemblathon retweeted
Happy to share this happy accident and collaboration we've been working on for the last two years!
In summary: We accidentally assembled a Poa pratensis reference genome.
biorxiv.org/content/10.1101/…
The Assemblathon retweeted
Has anyone written a genome assembly scaffolding algorithm that combines 10x linked reads and HiC data? If not, is there any reason why these wouldn’t combine complementarily to generate a higher resolution proximity matrix? #Genomics
The Assemblathon retweeted
nf-core/mag: a best-practice pipeline for metagenome hybrid assembly and binning biorxiv.org/content/10.1101/… github.com/nf-core/mag
The Assemblathon retweeted
The complete sequence of a human genome - finally…! biorxiv.org/content/10.1101/…
The Assemblathon retweeted
Metagenomic long-read assemblies often collapse closely-related strains/species. Here we assembled 428 high-quality MAGs from ~250Gb PacBio HiFi reads. ~50% MAGs have no polymorphisms, and we can phase the remaining ones. A collaboration with @BickhartDerek, Tim Smith et al.
Generation of lineage-resolved complete metagenome-assembled genomes by precision phasing biorxiv.org/cgi/content/shor… #bioRxiv
The Assemblathon retweeted
Yes we have no bananas (with assembly gaps) biorxiv.org/content/10.1101/…
The Assemblathon retweeted
Vertebrate Genomes Project publishes lessons learned from first 16 genome assemblies: plans to produce maps for 70,000 species of animals with backbones @ucdavisbiology @RockefellerUniv bit.ly/3e1uFKB
The Assemblathon retweeted
Long-Read Genome Assemblies Have 'Blind Spots' for Structural Variant Detection genomeweb.com/sequencing/lon…
The Assemblathon retweeted
Hey #GenomeAssembly tweeps, it strikes me that it would be useful to have two different assembly gap notations for high confidence (i.e. don't mess with) scaffolding and one for low confidence (correct if you can) scaffolding. Anyone else agree and/or done something like this?
The Assemblathon retweeted
Percent missing multi-copy genes as a measurement of assembly quality: lh3.github.io/2020/12/25/eva…
The Assemblathon retweeted
The Telomere-to-Telomere consortium is proud to announce our v1.0 release of a complete human genome. When @khmiga asked me to team up on this a few years ago, I wasn't sure it would be possible. Now down to just 5 gaps. What a journey! Read more here genomeinformatics.github.io/…
The Assemblathon retweeted
Like assembly graphs? Here, have ALL of them 😂
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The Assemblathon retweeted
For our birthday we are looking back at the highlights of our 8 years. 2013's highlight has to be @assemblathon 2: winner of #OpenData prizes, inspiration for #titusischucknorris memes, and quite pessimistic view of genome assembly doi.org/10.1186/2047-217X-2-… #gigascienceat8
The Assemblathon retweeted
I am excited to share the first T2T human chromosome. I am grateful to @aphillippy, @sergekoren and the entire #T2T team. This paper serves as an important milestone in genomics and calls for a new era for centromere research. nature.com/articles/s41586-0…
The Assemblathon retweeted
20 years after the announcement of the "working draft" of the human genome, we have the first complete assembly of a human chromosome. It's hard work to chase down every last base! rdcu.be/b5Dka
The Assemblathon retweeted
HapSolo: An optimization approach for removing secondary haplotigs during diploid genome assembly and scaffolding. biorxiv.org/cgi/content/shor… #biorxiv_bioinfo