Currently at @AstraZeneca. Previously @HFSP, @MCDB_Yale, @Gates_Cambridge, @MRC_LMB, @NagoyaUniv_info. Interested in Gene Expression Regulation & Public policy
New Haven, CT
Joined March 2014
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“Science alone can solve the problems of hunger and poverty, sanitation and illiteracy,of superstition and deadening custom and tradition, of vast resources running to waste, of a rich country inhabited by starving people”
- Pandit Jawaharlal Nehru
Anantha Narayanan retweeted
The latest preprint from GENCODE focuses on expanding and unifying lncRNA annotations. GENCODE: massively expanding the lncRNA catalog through capture long-read RNA sequencing biorxiv.org/content/10.1101/… @_Rory_Johnson_ @GOLDLab_UCD @GuigoLab @RodericGuigo @GencodeGenes
Elegant biochemical study from James Stowell, @connyyu, @lapassmore and team showing IDRs in RNA adaptors are fundamental for targeted deadenylation!
New work from the lab!
James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/
#RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
Exciting times ahead for Structural Studies! Congratulations @lapassmore on the appointment!
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Anantha Narayanan retweeted
Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/arti…
CryoEM at IITM! Super exciting. Perhaps time for me to go back home?!
The Cryo-Electron Microscopy (EM) Facility that I inaugurated at @iitmadras along with Prof Kamakoti, Director, IIT Madras and Prof T Pradeep brings India at par with the global league in the science of small objects, ranging from simple molecules to complex biological structures and composites.
Anantha Narayanan retweeted
DynaMight from @SjorsScheres @MRC_LMB models continuous structural heterogeneity in cryo-EM datasets, leading to an improved reconstruction of the consensus structure. The study also explores the issue of overfitting when modeling structural flexibility.
nature.com/articles/s41592-0…
Congratulations @palconh ! Great to see this out and an elegant example of combining single molecule work with cryoEM!
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It’s the week of pioneering factor reviews! Looking forward to reading this @_M_Carminati congratulations 🙌 🥳
Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA sciencedirect.com/science/ar…
Comprehensive review of pioneering TFs, how they might open chromatin and the big picture questions! Just read it in a single sitting during my commute! As a recent pioneering factor enthusiast, I found the article informative and it sparked many thoughts and ideas!
Proud to see this out now. We tried to give this topic a different perspective, put more weight on the MD simulations and NMR and look forward to the future that we believe should focus on dynamics.
link.springer.com/article/10…
Afternoon well spent at the Milner Therapeutics seminar. Great lineup of speakers from academia, big pharma and startups! Some of my key takeaways:
- Basic academic research is very much relevant and is the foundation for building new biotechs!
Anantha Narayanan retweeted
New preprint! 🧬🖥️ With the @FrogWalterLab, we created a predictome of nucleosome acidic patch binders using AlphaFold. Our approach identified both known and novel acidic patch interactors, opening new avenues for chromatin research. Check it out: biorxiv.org/content/10.1101/…
(1/3)
ALT Multiple proteins that interact with the H2A–H2B dimer acidic patch. Structures shown in ribbon representation.
What is the likely range of salt concentration inside the cell, especially the nucleus? Appreciate any references regarding such a calculation/approx measurement.
Anantha Narayanan retweeted
Sun et al. present a multiscale model on nucleosome packaging, offering insight into how ion concentration affects nucleosome core particle (NCP) condensation and chromatin folding in the cell nucleus. ow.ly/Jks950S8wKO
Anantha Narayanan retweeted
1000s of ligand-binding #riboswitch classes likely remain hidden in bacterial transcripts. In @NAR_Open, we report many new candidate #ncRNA classes (including the opuB riboswitch candidate shown below) discovered by careful bioinfo analysis of 50 genomes. tinyurl.com/yj2n47sj
A neat study on compaction and confirmations of IDRs in the human proteome! The compaction correlates with the function and cell localization!
Happy to share the publication of our paper in @Nature
Conformational ensembles of the human intrinsically disordered proteome
Work led by @GiulioTesei and @AnnaIdaTrolle. I'll post more later, but for now here is a link:
nature.com/articles/s41586-0…
and a short movie about the work
Anantha Narayanan retweeted
Today we're proud to announce that 36 new @Stormzy Scholarships will be awarded to Black students at the University of Cambridge over the next 3 years, bringing the total number to 81 🤎
cam.ac.uk/news/stormzy-2023
Anantha Narayanan retweeted
You’d think the fact that in 2023, PNAS still has a member-contributed track would be a bigger issue than eLife publishing high quality assessments of every paper it reviews. But trust academia to get its priorities mixed up.
“Let freedom reign.”
Remembering Nelson Mandela on his birth anniversary. #18thJuly #MandelaDay