@KeyserLab

We are a group of scientists at the Cavendish Lab, University of Cambridge, UK. Focused on understanding transport processes through membranes.

 Cambridge, England
keyserlab.org
Joined July 2019
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  • Following571
  • Followers1.2K
79Media
(1/n) How do we detect modified RNA, and DNA with the help of template-free, catalyst-free click chemistry and solid-state nanopores? 🧪🥼🧬🕳️
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Leveraging rRNA's 100,000-fold higher abundance over rDNA, we developed a one-pot method for RNA isolation, enrichment, and assembly of RNA identifiers, enabling detection of pathogenic bacteria and AMR variants without the need for amplification! 🧬🥼 @sarahesandler @KeyserLab
https://www.biorxiv.org/content/10.1101/2024.08.15.608086v1.full

ALT https://www.biorxiv.org/content/10.1101/2024.08.15.608086v1.full

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pre-print alert!🚨 @FilipBoskovic12 and I’s collaboration from our time in the ⁦@KeyserLab⁩ using #nanopores for serovar discrimination with single base pair specificity of rRNA is now on biorxiv! 🦠 biorxiv.org/content/10.1101/…

One pot RNA:DNA assembly for ribosomal RNA detection of pathogenic bacteria with single-molecule...

Effective treatment of infectious diseases hinges on timely and accurate diagnosis. Current methods face challenges in distinguishing between pathogens that cause a similar symptom and where approp...

biorxiv.org
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In a study led by @FilipBoskovic12 we examined how the electrophoretic transport of RNA:DNA and DNA through nanopores depends on the contour length rather than the number of base pairs. Nice blend of experiments and simulations! @aksimentievLab @acsnano 🧬🕳️⚛️ @Cambridge_Uni
Filip Boskovic@FilipBoskovic12
3 Jun 2024
_1/n Honestly, it has been an incredible experience to scratch the surface of the physics behind our applied work! Building on the work of nanopore crew, we've uncovered some unexpected clues about the electrophoretic translocation of duplexes and how their form affects velocity!
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🥳 New paper from the group! @casey_platnich has shown with nanopore sensing that the denaturing properties of urea can be used to break up RNA secondary structure and allow DNA staples to bind without heating! 🧬 Check out the paper in @J_A_C_S here:tinyurl.com/5bkx7nzv
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Great second session at @CamInfectDis Annual #Symposium @ksbakes @KeyserLab @Chris3Ruis @monkeymyshkin @RobinsonCamb – at Cambridge, England
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Check out our new article in @NatureComms ! We use RNA nanotechnology and nanopore sensing to assess transcript size and heterogeneity. We identify premature transcription termination, study rolling circle transcription and describe enzymatic processivity. Special thanks to everyone at @KeyserLab, @FilipBoskovic12 and our great collaborators @fondzanauku_rs. 🧬 nature.com/articles/s41467-0…
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Our latest paper collab with lots of great colleagues is now available in @an_chem, extending our solid-state #nanopore approach to analyzing the size distribution of heavy-chain modified #hyaluronan from physiological biofluids. pubs.acs.org/doi/full/10.102…

Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State...

Abstract. The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological functions where the distribution of its molecular weight (MW

pubs.acs.org
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While characterising harmful oligomers is crucial to developing accurate diagnoses and treatments for diseases involving misfolded proteins, like Alzheimer's, identifying them in complex mixtures has remained challenging. This new test may change that. chemistryworld.com/news/nano…

Nanopore test could identify misfolded proteins in Alzheimer’s ...

Sensor could provide more accurate diagnoses and help doctors track progress of neurodegenerative diseases

chemistryworld.com
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Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores | Journal of the American Chemical Society @Cambridge_Uni @DeptofPhysics @Maxwell_Centre #digital #Characterization #Misfolded #Protein #Nanopores pubs.acs.org/doi/10.1021/jac…

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

Abstract. Misfolded protein oligomers are of central importance in both the diagnosis and treatment of Alzheimer’s and Parkinson’s diseases. However, accur

pubs.acs.org
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Our paper is finally out in JACS! Exciting to see this collaboration (@KeyserLab,@VendruscoloLab) develop into a project with a lot of potential impact in both the fields of #protein #sensing using #nanopores and PD #diagnostics and #therapeutics 🧬💊 pubs.acs.org/doi/full/10.102…

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

Abstract. Misfolded protein oligomers are of central importance in both the diagnosis and treatment of Alzheimer’s and Parkinson’s diseases. However, accur

pubs.acs.org
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With Uli Keyser you always get the combination of cool physics and application driven assay development.
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Four of our physicists have been recognised in the @IOP Awards 2023 for their outstanding contribution to experimental physics, public engagement, soft matter physics, and atomic physics. Congratulations to them!🏅 Follow the thread to learn about the winners and their awards 🧵
Portrait photos of the 4 winners Hannah Stern, Harry Cliff, Ulrich Keyser and Ulrich Schneider, with the words Institute of Physics Awards 2023

ALT Portrait photos of the 4 winners Hannah Stern, Harry Cliff, Ulrich Keyser and Ulrich Schneider, with the words Institute of Physics Awards 2023

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Finally we are happy to announce that in the last week of September we spent an amazing time with the members of the DYNAMO consortium. Students under the guidance of professionals in the field of #nano presented their projects and defined goals for the future #DYNAMO #nanopores – at Finale Ligure, Liguria
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In a paper in @NatureNano, researchers @Cambridge_Uni went fishing for viruses using programmable DNA nanobait technology. @KeyserLab bit.ly/3Zu7M8L
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End-of-summer barbecue and foosball at Ulrich’s house 🍖 🌱 ⚽️ 🧬
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Check out my first first author paper of my PhD out now in @natBME ! We utilize solid state #nanopore sensing and #dna #nanotech as a way to assay #CRISPR #Cas9 binding efficiency!
Nature Biomedical Engineering@natBME
7 Aug 2023
Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores nature.com/articles/s41551-0…
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Latest review on nanopore protein sequencing, have a look!
Chang Liu@Chang_Liu666
25 Jul 2023
I am glad to see a year of hard work with @XiaojunWei2 and @aksimentievLab getting published today on ACS Nano! This is an exciting field with great potentials and we learned a lot writing this review paper: pubs.acs.org/doi/full/10.102… @UofSC_CEC @USCResearch

Engineering Biological Nanopore Approaches toward Protein Sequencing

Abstract. Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have for identifying

pubs.acs.org
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Check out our new paper in Nanoletters led by the talented Yunxuan Li, where we use DNA nanostructures and nanopore signals to characterize the physical properties of DNA! @NanoLetters @KeyserLab #dna #nanotech #nanopores pubs.acs.org/doi/10.1021/acs…

DNA Volume, Topology, and Flexibility Dictate Nanopore Current Signals

Abstract. Nanopores have developed into powerful single-molecule sensors capable of identifying and characterizing small polymers, such as DNA, by electrop

pubs.acs.org
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Delighted to annouce our work is out @nanoscale_rsc! A big team effort @KeyserLab @group_laser @mng_ceb @David_Holcman @NathalieRouach Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiology pubs.rsc.org/en/content/arti…

Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysio...

Dendrites and dendritic spines are the essential cellular compartments in neuronal communication, conveying information through transient voltage signals.

pubs.rsc.org
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