DeSci🧬Biohacking - Researching Canine Longevity @DogYearsDAO | Advisor to @UnlimitedBio | As seen on #UnnaturalSelection & #CitizenBio | šŸ³ļøā€šŸŒˆšŸ“ā˜Æļø

San Francisco
Joined December 2015
the "Hard Problem" in a nutshell: 1. atoms aren't conscious 2. humans are made of atoms 3. humans are conscious 4. so at least one of 1-3 must be false Panpsychists say #1 is false Dualists say #2 is false Illusionists say #3 is false Materialists say #4 is false
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Tristan Roberts retweeted
Former managing director at BGC Group/British banker-turned-whistleblower Simon Andriesz, the man who told the FBI about Lutnick/BGC’s ā€œfinancial irregularities,ā€ fraudulent 9/11 charity, and revealed Lutnick’s business partnership with Epstein in Adfin, has been found dead.
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Tristan Roberts retweeted
rationalists be like yeah this guy is probably a sociopath and maybe a rapist but he's charming and writes good so who can say if he's really bad
yeah I recall hearing a bit about someone getting kicked out of LO for sleeping over, maybe it was WBE. obviously if he's banned we won't have him at Manifest maybe this reflects badly on me, but I've actually read a lot of this person's substack, and found it, idk, at least quite captivating. (while not endorsing a lot of his behavior). I find his writing better written than ~half of inkhaven I also have a lot of sympathy for someone who just really doesn't have any money (he says, $800 net worth); but still wants to meet and talk to other interesting smart people. Manifest has historically provided many complimentary tickets to eg students for this reason seems like the kind of thing jesus would do?
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Replying to @anniealtman108
Annie is wearing her dad’s fleece. Jerry Altman had a known heart condition, but was overworking. Annie pleaded Sam to help their father’s retire. Sam never did. Then their father died of heart failure. Jerry left a trust to support Annie if she struggled with income. Sam colluded to hide the trust from Annie. Then they blocked access for years. Annie became homeless, struggled with severe health issues, and had to turn to sex work. This is all covered in the *second* lawsuit. Which btw, needs funds because Annie’s previous lawyers all left, and she had to get new ones. Please help get the story out xitter.cf/anniealtman108/status/…
Hello, my name is Annie Altman. My father, Jerry Altman, lived from October 4, 1950 until May 25, 2018. He loved sports, music, thrift shopping, and seeing his loved ones happy. I often wished and asked for him to be retired, especially due to his known heart conditions. Instead he died at age 67, while working more than overtime hours, including overnight road trips between St. Louis and Kansas City. After my Dad’s death in 2018, his assets were supposed to fund a trust for my benefit. Instead, my ā€œfamilyā€ did nothing to fulfill his wishes and hid the existence of the trust from me. You can find a history of his estate in the court file and see for yourself their inaction on: ww.courts.mo.gov/casenet/ Case Number: 25SL-PR02320 In the time without the support my Dad intended for me, I was homeless for more than three years, began survival sex work, and managed Elhers-Danlos Syndrome, PCOS (Polycystic Ovarian Syndrome), PTSD (Post-Traumatic Stress Disorder), and more. In 2024, St. Louis attorney Mike Gras helped show that the Trust did exist and I now receive monthly payments for my basic needs. These payments, that my Father intended for me to have after his death in 2018, allowed me to: finally have stable housing again after a 2021 home invasion, slowly stop the sex work I had begun for survival, and finally get major ankle surgery after seven straight years (and 12 years since the first walking boot) of pain. I am sharing this from my fourth week of recovery from said ankle surgery, where scar and other tissues were removed and an internal support was attached to my bones. The Trust is currently being managed by Parkside Financial Bank & Trust in St. Louis. I have not received all of the information I am entitled to about the assets in the trust, especially concerning my siblings' company Hydrazine. Hydrazine is a company founded by my eldest sibling Sam, and my other siblings Max and Jack have been employees of Hydrazine, all of whom I went no contact with in 2020. I filed a lawsuit in St. Louis County for their failure to fulfill my father's wishes, which can be found here: courts.mo.gov/fv/c/Petition.… Lawyers specialized in this kind of trust litigation require upfront retainers that are out of my capacity to afford. The court denied my request for the trust to cover my legal fees, so here I am. Thank you for helping me protect my Dad's wishes and legacy.
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He was onto something
Crazy, unexpected science news today: the brain is actually 2 colocated but independent organs that develop from 2 totally separate progenitor cells in early development. Big implications for some research areas (eg ALS) & for creating ethical brainless clones for transplant.
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Tristan Roberts retweeted
I was very strongly influenced by rationalism/LessWrong/EA growing up. This is why I don’t emphasize claims that it’s all just a cynical ploy for power. I know what it feels like to sincerely believe these things. And that’s much worse. By and large, I think these people really believe that not just the world but the entire lightcone is at stake, and the only hope for a good outcome is if they totally control AI development, which would require global governance and a surveillance state. And since the stakes are ~infinite, any means are justified in achieving this. A cynical greedy person can be negotiated with and bought off. A true believer can’t. They’re much more dangerous, ironically for the same reason they say AGI will be dangerous: monomaniacal focus on a single goal leads via instrumental convergence to unconstrained power-seeking.
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Tristan Roberts retweeted
The god these tech bros are worshipping is not AI, it's capitalism
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Tristan Roberts retweeted
Totally agree. I’d argue myostatin inhibitors and other muscle-preserving and generating therapies may even end up being bigger than GLP-1 drugs and a key second bridge to the longevity escape bridge in extending human lifespan.
The FDA just approved a myostatin inhibitor for a rare muscle wasting disease to prevent muscle loss. Guaranteed this will be approved soon to be taken with GLP-1s. Myostatin inhibitors will be as big as GLP-1s.
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Tristan Roberts retweeted
In two or three years there will be 10x the number of INDs and the same number of people you can recruit into a clinical trial. I don't understand what people think is going to happen. Everyone is funding molecular design but folks, we've got to also be funding new validation methodologies in a big big way.
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Tristan Roberts retweeted
Fourteen moves in eight days The psyop to create hysteria to manipulate Congress into regulating AI. Almost everyone involved is affiliated with Coefficient, Open Philanthropy, Anthropic, and/or OpenAI -- all who serve to benefit financially from creating regulation.
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Tristan Roberts retweeted
Sorry, but it's not just Anthropic. Palantir has been working on predictive policing and surveillance of dissidents for the US government for well over a decade. The goal of the Bush admin immediately after 9/11 was pre-crime via "Total Information Awareness" and they have been building it ever since, through the privatization of that program as Palantir. And there are other companies working toward this end to, all with ties to US intelligence or top US officials (Satellogic, SpaceX, Axon/Carbyne, etc.) Anthropic may be "building" their own private equivalent, but this is something the government and its other private contractors have already built. Under the first Trump admin, Bill Barr as AG created the legal framework for pre-crime. They are just waiting on the right excuse or justification to scale it. We have to realize how far along this is if we really want to stop it. It is now many companies ushering in a pre-crime paradigm, all with State backing.
Anthropic Is building a surveillance system to monitor activists using a ā€œpre-crimeā€ approach that tries to predict incidents before they happen. The extensive monitoring system that the AI company is building is aimed primarily at keeping tabs on activists who oppose the rapid development of artificial intelligence. More from @DRBoguslaw below: prospect.org/2026/09/09/anth…
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Tristan Roberts retweeted
Everyone has lost their minds. If you are going to claim that a statistical regression of all of the world’s data is going to destroy humanity, describe the logical progression. A statistical model has no agency or intelligence. It’s just a relational database of information. So there are no scenarios where a database rises up and ends humanity without some human(s) on the back end deciding to allow it. These humans would be responsible for crimes and should just be prosecuted like every other criminal. The problem is not a really big scary database, the problem is human criminals that are not held to account for their crimes.
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Tristan Roberts retweeted
the chance AI will kill us all is close to 0% the chance that Anthropic or OpenAI want to have ultimate control over humanity is close to 100% few understand this.
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Tristan Roberts retweeted
LessWrong utilitarianism has all the features of Levantine religious fanaticism: obsessive, abstract, uncompromising, infinitary, graphomanic, self-sacrificial, and of course based on slave morality from beginning to end.
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Tristan Roberts retweeted
its worth pausing to notice how many major recent findings across the sciences driven by models seem to recover aspects of christian metaphysics as seemingly innate to the systems they are learning in the case of levins paper, staggeringly coherent reconstruction of logos
Here it is - the official, revised, peer-reviewed version of my Platonic Space paper. mdpi.com/2409-9287/11/5/161 Of all the many unpopular positions I’ve taken over the decades - bitter controversies around the origin of left-right asymmetry in embryogenesis, bioelectricity and genetics, diverse intelligence, etc., this one has by far generated the most pushback: serious (grateful for those!) and energetic attempts to move me to other views, pleas to just drop it and not talk about it (for several different reasons), nasty emails and accusations, impacts on reviews of papers that have nothing to do with this, etc. Kind of amazing to me how incendiary this is. What can I say... Our job is to call it as we see it, and right now for me, this is it. Apologies to collaborators and colleagues for any shrapnel! Time will tell if this pans out or not; I've placed my bets. And btw, if you think this stuff is weird and uncomfortable, just wait… There’s much more on the way. The knob turns slowly but as long as the data keep coming, I'm going to say what I think it all means and follow it to the next steps it enables. Buckle up!
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Tristan Roberts retweeted
The only way to ensure that mass surveillance tools like Flock Cameras won’t one day be used by despots to round up political dissidents for execution is for such tools not to exist at all. If you think that’s hyperbolic, you know little of history and even less of human nature.
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Tristan Roberts retweeted
The danger of psychedelics isn't MDMA putting holes in your brain, LSD making you jump out of windows, or shrooms making you crazy. The danger lies in new perspectives. You see that everything that society cares about doesn't matter. You're alienated. This is the price you pay.
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Tristan Roberts retweeted
the most important thing i learned from rationalists is that smart people can be incredibly stupid. you have the god-given right to refuse to defer to anyone’s authority no matter how smart they seem if they’re talking nonsense, and intelligence is no substitute for wisdom
Rationalist Hadith
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Tristan Roberts retweeted
Vorinostat might be the swiss knife drug - grows bones (runx2 upregulation + dkk-1 suppression), force stem cells into forming bone (wnt) - wakes up dormant HIV out of T cells - restores memory function - neuroprotective - anti fibrotic, heart protective - switch genes on HDAC
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Tristan Roberts retweeted
What is stopping us from all giving our pets longevity peptides as they near the end of their life? Worst case scenario nothing changes. Best case you get more time with your best friend. Either way we get anecdotes.
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