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Soviet pharmacologists searched for a better compound than BROMANTANE to expand their military/space medicine applications, and created CHLODANTANE
It had a much wider spectrum of defense:
hypoxia, freezing cold, toxic chemical exposures, pronounced immune/antioxidant effects..
gaezv retweeted
if you are on amphetamines and want to prevent long term issues, a simple blood pressure medication will go a long way
not many people know this but several long term issues with amphetamines are NOT about dopamine, instead its linked to the AT1R receptor
- AT1R contributes to amphetamine induced oxidative stress and damage
- amphetamines increase astrocyte reactivity in the PFC, an effect reduced by AT1R inhibition
- amphetamines can enlarge blood vessels while reducing their growth in the PFC, through AT1R
- long term amphetamine abuse can impair memory, AT1R blockers can protect against these
- AT1R regulates dopamine production and release while amphetamines can change AT1R activity
the AT1R blockers called telmisartan and candesartan are what you are looking for and are what you want to use in combination with amphetamines
importantly, amphetamines do not bind directly to AT1R, the effects are downstream
Pyridostigmine, mildly increase GH
It inhibits acetylcholinesterase, increasing ACh tone in the hypothalamus, then suppressing somatostatinergic neurons, which unopposes GHRH
GH peaked by 4-5x, peaking at 2h, similar to light exercise, combining both made an even bigger peak
Pregnenolone for neuroprotection, basic but still decent
- anti apoptotic
- suppresses M1 microglial activation through TLR2
- potentiates NMDA at sigma-1
- helps sleep
- supports memory consolidation
- neurogenesis
- glutamate excitotoxicity protection
- pro myelin synthesis
PA-915, is also fascinating for elevated CORTISOL cases, an antagonist of PAC1 receptor (amygdala, mPFC..) REGULATING STRESS
The PACAP–PAC1 pathway is a modulator of HPA axis
- Normalizes corticosterone
- Restores dendritic spine density (like Ket)
- Antidepressant + anxiolytic
Instead of taking ashwaganda you should take phosphatidylserine
Ashwaganda lowers basal cortisol levels. The really painful thing here is that people deploy it despite never actually getting their cortisol tested. "I'm stressed. I need to lower my cortisol" well did you get your cortisol tested? "No but I just feel like it's high"
Utter brain death
Phosphatidylserine acts in a much more elegant manner by modulating stress-induced cortisol responses by reducing ACTH release and subsequent adrenal cortisol secretion induced by things like exercise or other stressful activity. This makes it an excellent, non-stimulating, pre-workout ergogenic
PS also acts as a component of neuronal membranes and can even improve memory under certain conditions. It also influences cholinergic signaling and acetylcholine release. Ashwaganda does not do anything for your cognition
I find that most people supplement something based on pure vibes and end up doing something retarded in the long run and waste a ton of money. The only use case for ashwaganda is to attenuate chronically elevated cortisol levels, confirmed by an actual cortisol test, and even then there are better options. Do better
gaezv retweeted
INT131 mogs pioglitazone to death
- 2mg Same HbA1c drop as 45mg Pio
- Less water retention / None at 1mg
- Less weight gain / None at 1mg
- Less edema / None at 1mg
- 20x higher PPARγ affinity (partial)
- Neuroprotective
- Helps w AGEs
- Metabolism benefit
- Insulin sensitivity
It is a linear calculation based on the data there on the image to calculate 2.5 mg EOD peak and throughs levels. Then get the IC50 values from published studies on GluN2A/2B
tiktok.com/@humanupgraded/ph…
Full tiktok breaking it down, i cannot break it down in a whole tweet, i do not have premium lol, but yeah that guy breaks it down pretty well
