@adamnitido

Virologist | Research Fellow @ Ragon Institute

 Cambridge, MA
Joined December 2019
  • Tweets54
  • Following232
  • Followers113
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Why do some broadly neutralizing antibodies (bNAbs) suppress HIV in vivo—while others fail—even when they look equally potent in vitro? We address this in our new study in @ImmunityCP: authors.elsevier.com/c/1mgR9… @BalazsLab 🧵👇
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When we experimentally increased the fitness cost of escape mutations, we converted partial suppression into durable viral control in humanized mice.
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These findings suggest that effective bNAb therapies should be designed not only for breadth and potency, but to maximize the evolutionary cost of resistance. Grateful to collaborate with Nicolás Gálvez Arriagada and the exceptional team @BalazsLab. authors.elsevier.com/c/1mgR9…
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Adam Nitido retweeted
Balazs Lab@BalazsLabFeb 25
Our latest manuscript just came out in @ImmunityCP describing over a decade of work in the lab studying HIV evolution and escape from HIV broadly neutralizing antibodies. authors.elsevier.com/a/1mgR9…
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HIV deciding whether to take the easy way, or the hard way around an antibody.

ALT HIV deciding whether to take the easy way, or the hard way around an antibody.

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'Virology—The next fifty years' - a perspective by Eddie Holmes, @GoodrumVirusLab and myself in Cell cell.com/cell/fulltext/S0092…
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QuickFit: A high-throughput RT-qPCR-based assay to quantify viral growth and fitness in vitro biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Adam Nitido retweeted
Balazs Lab@BalazsLab14 Mar 2024
Our preview of a new paper describing the development of a new mRNA vaccine against mpox is now available online. Thanks to @adamnitido for the great team effort putting this together! sciencedirect.com/science/ar…
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Adam Nitido retweeted
Douam Lab@DouamLab12 Mar 2024
New pre-print from the lab🥳🥳!! Amazing team effort between @DouamLab, @BalazsLab and Christelle Harly's group in Nantes. Congrats to @DevinKenney10 for spearheading the work. biorxiv.org/content/10.1101/…

Resolution of SARS-CoV-2 infection in human lung tissues is driven by extravascular CD163+ monocytes

The lung-resident immune mechanisms driving resolution of SARS-CoV-2 infection in humans remain elusive. Using mice co-engrafted with a genetically matched human immune system and fetal lung xenogr...

biorxiv.org
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Adam Nitido retweeted
RonGeller@RonGellerLab8 Mar 2024
Ever wonder why despite the extreme mutation rates of RNA viruses, diversity in nature is concentrated in a few viral proteins? Could it be because viral proteins have different abilities to tolerate mutations? Our full proteome DMS study looks at this! biorxiv.org/cgi/content/shor…
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I will be defending my Ph.D. dissertation (via zoom) on August 24 at 11AM ET! If you want to watch it, send me a DM, and I'll share with you the link.
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Adam Nitido retweeted
Balazs Lab@BalazsLab8 Jul 2022
Our preprint is live! We find that IgG antibody subclass has a big influence on protective efficacy of VRC07 broadly neutralizing antibody against vaginal HIV transmission in humanized mice. We also show that even a little VRC07 yields protection in vivo. biorxiv.org/content/10.1101/…

Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized...

HIV broadly neutralizing antibodies (bNAbs) are capable of both blocking viral entry and recruiting innate immunity to HIV-infected cells through their fragment crystallizable (Fc) region. Vaccinat...

biorxiv.org
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Adam Nitido retweeted
Balazs Lab@BalazsLab20 Jan 2022
We are looking to recruit new techs to join the lab and help us engineer immunity against SARS-CoV-2 and HIV infection! If you are passionate about virology and immunology and want to be part of creating the next-generation of interventions please apply! partners.taleo.net/careersec…
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Our method to improve confidence and prevent common errors in SARS-CoV-2 sequencing is out in @NatureMicrobiol. What started as a pandemic scramble to help out in some way, turned into project and team I am so proud to be part of! nature.com/articles/s41564-0… a brief overview: (1)
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Adam Nitido retweeted
Balazs Lab@BalazsLab14 Dec 2021
Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfredo_nk, @kstdenis29, @EvanCLam, @adamnitido, @NaranbhaiVivek who have been up at all hours of the night both at the bench and writing the paper! 1/16
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First day of #HumanViruses Dynamics & Evolution conference. I’ll give a flavour in the thread below. HIV & SARS-CoV-2, sequencing & modelling & immunology. Talks listed here cpd.ucsd.edu/hivdynamics/age…. Organisers @manonragonnet @sergeilkp @ucsandiegocme @ucsdcme 1/N
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Adam Nitido retweeted
Balazs Lab@BalazsLab17 Feb 2021
If anyone is interested in reading the complete pre-print, it is now available for download on out lab's website: balazslab.partners.org/
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Adam Nitido retweeted
Balazs Lab@BalazsLab14 Feb 2021
We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2. Before it posts online, I'd like to put them into context. A thread: 1/12
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