Prof at Korea Univ / Co-founder & CEO of MxT Biotech

Seoul, Republic of Korea
Joined October 2010
In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles nature.com/articles/s41587-0…
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Lipid nanoparticles chart path beyond the liver nature.com/articles/s41587-0… [🔓read free with login]
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For readers interested in the potential of in vivo CAR-T cell therapies for cancer and autoimmune diseases, here's a comprehensive review by pioneers in the field rdcu.be/koc33UDidsza nature.com/articles/s41573-0…
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Excited to share that Spatial Hi-C-RNA is now out in @CellCellPress! It brings the 3D genome into spatial multi-omics by co-mapping chromatin architecture and gene expression in the same tissue section. Congrats to the whole team! cell.com/cell/fulltext/S0092…
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mRNA technology is one of the platforms being used for n-of-1 therapies. Read about its application in this and a range of other areas such as in vivo CAR-T cell therapies and cancer immunotherapies in this Review nature.com/articles/s41573-0… rdcu.be/fteeb
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Aram Chung retweeted
Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production 🇮🇹 nature.com/articles/s41392-0…
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Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors go.nature.com/4atBJML
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Aram Chung retweeted
In cancer, activated T cells release abundant extracellular vesicles that transfer DNA to the nucleus of tumor and immune (dendritic) cells, turning tumors from cold to hot. An immunotherapy in the works. @Cancer_Cell sciencedirect.com/science/ar… sciencedirect.com/science/ar…
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CAR-X cell engineering dlvr.it/TSG6WV
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A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery go.nature.com/4ugPm9D
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Aram Chung retweeted
Macrophage senescence is a central driver of chronic inflammation in aging and metabolic liver disease, and a tractable therapeutic target.
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A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery #NBTNV go.nature.com/4s4X7P7 rdcu.be/fdfzQ
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Aram Chung retweeted
Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers nature.com/articles/s41591-0… nature.com/articles/s41591-0…
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For readers interested in lipid nanoparticles for oligonucleotide delivery, here's an article covering 60 years of progress in the field rdcu.be/fb9xD nature.com/articles/s41573-0…
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