RIKEN (CODATA, WDCM ...) - NIG (CODATA, DDBJ/CIB, WDCM, OECD BRC, GBIF, JST BIRD, TPRP ...) - FREE
Tokyo (Web site in Japanese)
Joined January 2017
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高齢ドナーの赤血球前駆細胞から、分子年齢が元の約5～13%の神経幹細胞へ：ボン大学などが捉えた「ゆっくり進む細胞若返り」の意義
(Aging Cell誌刊行論文から）
crisp-bio.blog.jp/archives/4…
“Protracted Fate Acquisition and Epigenetic De-Aging During Induced Neural Stem Cell Conversion of Human Blood Cells”
Jessica Berg LJ, Franzen J, Buness A [..] Brüstle O.
Aging Cell. 2026-10-03.
doi.org/10.1111/acel.70751
NEWS “Researchers Transform Old Blood Cells into Young Brain Cells”
Universität Bonn. 2026-10-09.
uni-bonn.de/en/news/211-2026
NEWS “Researchers Transform Old Blood Cells into Young Brain Cells”
Universität Bonn. 2026-10-09.
uni-bonn.de/en/news/211-2026
【NATURE】中国は科学分野を牽引していく波に乗っている、科学分野の勢力地図を塗り替えるところまでいきそうだ
(10月14日付NEWS FEATURE記事から)
crisp-bio.blog.jp/archives/4…
NEWS FEATURE
"China’s extraordinary rise in science and how it will change the world."
Xiaoying You. Nature 2026-10-14
doi.org/10.1038/d41586-026-0…
The nation is on a trajectory to lead the world in science, a development that will reshape technological advancement, innovation and the balance of global power.
因子322種類の機能を解明：単一細胞レベルでのプール型CRISPR/Cas9スクリーニングを介して
（Cell Stem Cell誌刊行論文から）
crisp-bio.blog.jp/archives/4…
322のエピジェネティック因子は、遺伝子発現への影響の類似性から、9つの摂動クラスター（PC0～PC8）に分かれ (下図参照)、下流の遺伝子も12の遺伝子プログラム（GP0～GP11）にまとまりました。
#HSPC #細胞系譜 #scCRISPR #AML
"Single-cell CRISPR screen maps epigenetic regulators of lineage specification and malignancies in human HSPCs"
Yuan S, Yang S, Huang Y, Ma B [..] Cheng H, Wei J, Cheng T.
Cell Stem Cell. 2026-10-13/11-05.
doi.org/10.1016/j.stem.2026.…
#scCRISPR #HSPC #epigenome #AML
生細胞タンパク質標識用の高親和性スプリット型HaloTagを開発
(Nature Communications誌刊行論文から)
crisp-bio.blog.jp/archives/3…
アデノ随伴ウイルス (AAV) の高用量投与に伴う毒性の軽減を目指して代替受容体を探索・特定
(Cell誌掲載論文から)
crisp-bio.blog.jp/archives/3…
イチゴの「四季成り性」の鍵は TFL1 (TERMINAL FLOWER 1) にあった ― CRISPR編集で一季成り品種に四季成り性を再現
(Plant Physiology刊行論文から)
crisp-bio.blog.jp/archives/4…
#CRISPR #花成制御 #イチゴ
“CRISPR editing of TERMINAL FLOWER 1 recapitulates perpetual flowering in strawberry, mimicking repression by the PERPETUAL FLOWERING locus”
Bjornson M [..] Feldmann MJ, Knapp SJ.
Plant Physiology, 2026-10-09.
doi.org/10.1093/plphys/kiag6…
This is not a view of the Earth at night.
What you see glowing are the locations where earthquakes have occurred.
When you visualize earthquakes around the globe, what initially look like random events actually reveal remarkably clear "lines."
The area around Japan is insane.
This visualization maps out not only the "locations" of earthquakes, but also their "depths" in 3D.
Earthquakes do not occur randomly across the globe; instead, they are concentrated in band-like zones along plate boundaries.
Looking closely around Japan, you can also see hypocenters aligning diagonally into the earth. This happens because earthquakes occur along subducting plates.
Note: The depths of the hypocenters are exaggerated by 8x for better visibility.
[レビュー] CRISPR/Cas9のオンターゲット活性, オフターゲット編集リスク、および編集結果のディープラーニング（DL）による予測：その現状とマルチスケールな視点
(Journal of Translational Medicine 誌刊行レビューから)
crisp-bio.blog.jp/archives/4…
現行DLモデルの限界「構造的盲点 ("structural blind spot")」を超える「3層フレームワーク (“three-layer framework”)」を提唱
REVIEW "Deep learning–driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives"
Weian Du, Tingfeng Zhang [..] Hong Hu, Ling Chen, Chao Liu
J Transl Med 2026-04-28
doi.org/10.1186/s12967-026-0…
イネにおいて白葉枯病耐性を担う5,10-ジケト-カスベン（DKC）を然るべく輸送するABCGトランスポーターOsPDR17を同定
(New Phytologist誌刊行論文)
crisp-bio.blog.jp/archives/4…
“The ABCG transporter OsPDR17 mediates transport of 5,10-diketo-casbene and enhances disease resistance in rice.”
Wang R [..] CHen Y.
New Phytol. 2026-10-03
doi.org/10.1111/nph.71629
... rice resistance to bacterial blight
がんによるビタミンB2の競合が、T細胞のフェロトーシスに関する代謝チェックポイントを形成する
(Cell誌刊行論文から)
crisp-bio.blog.jp/archives/4…
“Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis”
Huanpeng Chen, Chao Li [..] Yingjie Bian.
Cell 2026-10-06.
doi.org/10.1016/j.cell.2026.…
CareSLCs: chimeric antigen receptor (CAR)-single-guide RNA (sgRNA) evaluation of SLCs
#CRISPR-Cas9 screening
生細胞のRPIを「記録・監視・探索」する：CRISPR/dCas13ベースの最新多角的解析ツール群
(NAR論文から)
crisp-bio.blog.jp/archives/4…
“Development of CRISPR/Cas13-based analytical tools to study RNA-Protein Interactions.”
Yamamoto k [..] Goyama S.
Nucleic Acids Res. 2026-10-14
doi.org/10.1093/nar/gkag928]
"BiFC-dCas13, NanoBiT-dCas13 & split-TurboID-dCas13" for recording, monitoring, and discovering RPI-associated biology and molecular environments.
