Grad student interested in mechanobiology!

Singapore
Joined August 2020
4
6
266
Excited to share two back-to-back manuscripts on microtubule lattice organization! The first, led by Jaya Mishra from my lab, describes how short, curved microtubule filaments can be used as a simple in-cell readout of compact microtubule lattice regions.
1
4
8
761
I realize I wasn't clear before: On the QED website you can see scores for ALL THE PREPRINTS THAT WERE PUBLISHED THIS YEAR NOT JUST FOR THE 1%. We highlighted the people who got a perfect score (they they were interviewed, their pictures are there, and you can hear their stories) but all the other preprints (including you!) are there. Maybe your score is 98%, that's fantastic, but it's not on the list that's displayed. Check it out.
Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers. When we launched QED a little over half a year ago, I told you that our mission is to revolutionize scientific publishing. Revolutions don’t happen overnight… or maybe they do? When new technologies enable it? Time to put the power back in the scientists’ hands, not the journals’. Many scientists are depressed, and think journals will stay the same forever, no matter how dysfunctional, but no, it’s happening. Sooner than most people (or committees, or universities) can imagine. Check this out: When we released our AI review platform, it started a whole debate (and social media storm) on what it is that human reviewers can do that AI review still can’t. There are such things (and I’m happy about it), but the list is getting shorter and shorter. Numerous scientists already use QED to find gaps in their manuscripts and grants and to get constructive feedback that improves their experiments. And now, with your help, we take it to the next level. Today we release reviews and scores for all the experimental Life Science pre-prints that came out last year: 57,455 manuscripts!! If we are being conservative, and estimate that it takes a minimum of 8 hours to review a paper (it takes longer), and if we agree that 3 reviewers are typically required to review every submission, then reviewing this amount of manuscripts would take human experts >1 MILLION REVIEWER HOURS… Assuming you can find so many experts (not going to happen!), and assuming the experts who agree would have no conflict of interest (ha!!). QED did it. Then, we chose the best papers in every field (you can browse and search for key words), based on the originality and validity of the claims being made. We benchmarked our reviews not only using eventual journal selections but also by comparing our evaluations to those of human experts. When there were disagreements between the QED score and journal rank, we asked domain experts to judge who’s right (blindly), and they overwhelmingly sided with QED. No need to rely on glam journals anymore. No need to wait for two years to get their stamp of approval. No need to beg the reviewers, or worse, to write less ambitious papers, so no one would be upset. Want to find the most interesting papers in your field? Want to see where your paper stands? (“What’s your QED SCORE?”) Just visit qedscience.com! One last thing: We want good science to be seen (you can read the winners’ comments about their selection and the stories behind their discoveries on our website). We plan to organize a conference where the first authors (yes, the first authors, not the PIs) will present their work. We are not here to shame anyone (papers that got low scores). The reviews of the best papers that we selected explain why QED’s AI thought these papers are especially good - what’s unique about them, what their strengths are, which conceptual leaps were made, and what cutting-edge tools were developed. However, on the QED Science site you can analyze any paper in private, it’s fully transparent, and see if there are any gaps and what’s missing. Run your paper to see how it can improve, and maybe next time your paper will reach the top (if it’s not there already). Whether you’re on the 1% list of just have a good score that you want to share, on our website you can download the report and share it, for example with your tenure, promotion, or hiring committee, or with your university PR department. Forget about journal embargoes and waiting for it to be “accepted”. Improve your work until it’s good enough for YOU. You decide.
1
3
19
11,549
Congrats to @nicoleleejw (and other @ConfinementLab co-authors) on her main story coming out this month in @CellReports! Check out this thread if you’re interested in what Nicole discovered on the role #MechanicalMemory plays in facilitating cell migration in #confinement
1
4
1
23
2,247
Reading a paper is easy. Interrogating a paper is where thinking begins. "Good Research Comes From Good Questions."
3
183
3
869
26,929
Troponin I (slow skeletal) is our #CellLineOfTheWeek! ❤️🔬 Our human stem cell lines & plasmids are openly available to reduce the barriers to scientific discovery. 🧫🚀 📦 Distributed by @Coriell_Science & @Addgene #OpenScience
1
20
1
75
11,975
Check out this editorial in Circulation Research by Dr. Marie-Louise Bang about our paper on alpha-actinin-4 in the cardiac Z-disc. It both summarizes our findings really well (image gives a taste of it; there is more) and lays out future directions. ahajournals.org/doi/10.1161/…
2
22
1,423
Our final #preprint list of 2025 is now up on FocalPlane! In this post, we focus on recent (and recently updated) preprints in bioimage analysis. Let us know if you have any recommendations of preprints that we have missed. focalplane.biologists.com/20…
11
46
3,652
Human monocytes placed on a soft matrix undergo phase separation into micro domains. On glass/plastic, monocytes do not form such domains. See more details in our recent paper in Nature Materials: nature.com/articles/s41563-0…
6
28
3
151
57,488
Depending on your data type, use the right plot to tell the story. A nice interactive app to determine what plots you need data-to-viz.com/
1
25
149
10,019
Analyzing organelles is HARD. They're complex, but critical to understanding biology. Current tools are manual, organelle-specific, or can't handle large 3D datasets. With an easy install and a click of a button, Nellie solves ALL these problems! nature.com/articles/s41592-0… 🧵2/N
1
4
22
1,577
A hungry heart muscle cell (cardiac myocyte) videoed through a microscope by Burnette Lab graduate student, @EmmaKoory. What is it eating and why? We may never know....... #CellBiology
2
37
137
7,451
Been doing a lot of time lapses of iPSC-derived cardiac muscle cells lately! Here's one of my favorites. This cell is expressing fluorescent alpha-actinin-2 and the colors represent depth. Movie length = 24h with frames taken every 20m. #microscopymonday #cellbiology @MAG2ART
7
22
1,610
I made this muscle myosin II expression plasmid with a fun surprise on it that, if I can get to work, will be big. Stay tuuuneddd
iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. Could we use these rare cells to uncover mechanisms underlying arrhythmias? Probably, but the way the Burnette Lab would approach that would require a lot of description-- I apologize for using such filthy language. Description indeed...... Grant reviewers hate the uncertainty that word implies; "What if they just take a bunch of videos with their microscopes?" Well, we would do that....... and some other stuff...... the idea that we would not discover something new along the way is laughable. The "other stuff" would be pretty cool. This video shows an iPSC-derived cardiac myocyte videoed by Burnette Lab graduate student @EmmaKoory. Muscle myosin II is shown. #CellBiology
2
3
266
"Non-Muscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling" is now online at Circulation Research! Congratulations to Dr. James Hayes on this ambitious work! There is a lot in the paper so let's start with the graphical abstract. @CircRes ahajournals.org/doi/10.1161/…
5
16
59
3,450
New preprint from @JieYan_NUS @ChaoyuFu
Replying to @MBIsg
@MBIsg @ChaoyuF Mechanical forces shape cell fate, proliferation, and migration. But how do adhesion GPCRs (aGPCRs) turn physical cues into biochemical signals?
2
7
953
Happy to share latest review from the lab: sciencedirect.com/science/ar…. Stay tuned with our upcoming special issue on Environmental control of oogenesis and ovarian dynamics in Seminars in Cell & Dev. Biology!
1
4
17
1,692
MBI Fellow Yee Han Tee, co-chair for Session 3, spoke movingly about Mike’s contributions to science and Singapore, his mentorship, and the importance of the ‘Friday night’ experiment for testing new ideas! #MBIMPG2025
1
6
535