"a 67-year-old woman [with a history of multiple myeloma and recent exposure to a COVID-19-positive individual] developed rapidly progressive neurological symptoms, including dysarthria, dysphagia, and hypoesthesia, without any respiratory manifestations.. SARS-CoV-2 infection was confirmed.. Her condition deteriorated to focal and dyscognitive status epilepticus.. Brain MRI showed imaging features consistent with rhombencephalitis. Further analysis of the CSF using quantitative shotgun proteomics via mass spectrometry revealed a neuroinflammatory profile indicative of blood–brain barrier disruption and differential expression of several proteins relevant to brain function, including the major prion protein, superoxide dismutase 1 (SOD-1), and other aggregation-prone proteins. [In conclusion, ] This case supports the hypothesis that SARS-CoV-2 can invade the central nervous system and cause severe neurological impairment, even in the absence of typical respiratory symptoms. The findings underscore the importance of considering SARS-CoV-2 in the differential diagnosis of rapidly progressive neurological syndromes.." The challenge is that such important findings are often overlooked owing to the concentration decline caused by SARS-CoV-2. 'Cerebrospinal fluid positive for SARS-CoV-2 associated with neurological manifestations and proteome alterations in a multiple myeloma patient' link.springer.com/article/10…