@_adamewing

🧬

Joined June 2019
  • Tweets70
  • Following191
  • Followers181
R2Dtool github.com/comprna/R2Dtool for handling, integrating, and viualising isoform-resolved RNA feature data - led by @_AJSethi #bioinformatics #RNA #isoforms academic.oup.com/bioinformat…

GitHub - comprna/R2Dtool: Analyse RNA feature distributions.

Analyse RNA feature distributions. Contribute to comprna/R2Dtool development by creating an account on GitHub.

github.com
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Adam Ewing retweeted
kez cleal@kezcleal26 Jul 2024
So happy to see this out today - our ultra-fast genome browser GW v1.0 #Genomics 🚀 biorxiv.org/content/10.1101/…
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Adam Ewing retweeted
John Greally@greally18 Jul 2024
Interesting observation from @TreyIdeker and colleagues: could #epigenetic ageing clocks reflect somatic mutation rather than cellular reprogramming? Good rule of thumb: whenever there's an "epigenetic" change, look for a genetic change. biorxiv.org/content/10.1101/…

Somatic mutation as an explanation for epigenetic aging

DNA methylation marks have recently been used to build models known as “epigenetic clocks” which predict calendar age. As methylation of cytosine promotes C-to-T mutations, we hypothesized that the...

biorxiv.org
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Have you signed this yet? You should. HDR students shouldn't be struggling to put food on the table and pay rent, on top of the other challenges they already face. Petition closes 24 July 2024, 11:59 PM (AEST).
Prof. Euan Ritchie (@euanritchie.bsky.social)@EuanRitchie116 Jul 2024
HDR students work extremely hard & they aren’t paid anything near what’s reasonable. The current minimum stipend is $32k p.a., ~ $12k below the national minimum wage. Students deserve better, please share & sign this petition. Raise the HDR Stipend aph.gov.au/e-petitions/petit…
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What has 126 figure panels and a completely new antiviral pathway? The @GammonLab's latest paper in @NatureMicrobiol, featuring student Emily Rex's tour de force discovery of the FEAR pathway. Huge congrats to the team! nature.com/articles/s41564-0…
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Amazing results from @sergekoren. Near perfect assembly of human, ont only. "We found the accuracy of Duplex data to be similar to HiFi sequencing, but with read lengths tens of kb longer, .... assemblies have a base accuracy exceeding 99.999% (Q50) and near-perfect continuity"
bioRxiv Bioinfo@biorxiv_bioinfo17 Mar 2024
Gapless assembly of complete human and plant chromosomes using only nanopore sequencing biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
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What are the consequences of aberrant de-repression of germline genes in placental development? We discuss it in our latest hypothesis article! onlinelibrary.wiley.com/doi/…

Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant...

DNA methyltransferase 3B (Dnmt3b) knockout conceptuses show embryonic lethality due to impaired placental formation. These placental cells exhibit aberrant DNA methylation and de-repression of...

onlinelibrary.wiley.com
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🐭🧬Our paper on locus-specific mouse L1 activity and regulation, led by the indomitable @Patricia_Grds is out @genomeresearch!🧬🐭 This study evolved from a simple question: what defines the mutagenic potential of a new L1 copy in vivo? genome.cshlp.org/cgi/content… A thread: 1/n
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Registration is now open for Australia's biggest bioinformatics event of the year. With amazing support from @iscb, our incredible organising committee has been working hard to ensure this year's @abacbs conference will be exceptionally fun & useful. Stay tuned for more updates!
Cheong Xin (CX) Chan@dorkyM25 Jul 2023
Replying to @abacbs
@abacbs 2023 website now live, Registrations & Call for Abstracts now open! Excited to collaborate w/@iscb, and we have an awesome line up of invited speakers & diverse session themes this year! See you in Brisbane #bioinformatics #genomics @combine_au 2023.abacbs.org/
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PLEASE RT💜🧬: The final report of our genetic discrimination project is out today at doi.org/10.26180/23564538 It makes clear recommendations to the Aus government to prohibit the use of genetic test results in risk-rated insurance underwriting. A thread about our findings... 1/5
A-GLIMMER recommendations

ALT A-GLIMMER recommendations

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"Rare penetrant mutations confer severe risk of common diseases" medrxiv.org/content/10.1101/…

Rare penetrant mutations confer severe risk of common diseases

We examined 454,712 exomes for genes associated with a wide spectrum of complex traits and common diseases and observed that rare, penetrant mutations in genes implicated by genome-wide association...

medrxiv.org
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Adam Ewing retweeted
ABACBS@abacbs20 Apr 2023
@abacbs is excited to announce that this year’s Conference will be held 4 – 8 Dec in Brisbane, for the first time in collaboration with the International Society of Computational Biology @iscb! Please save the date and start planning your trip! Info coming soon… @dorkyM @UQ_News
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Maybe you can cheat death...(or at least use it to break free) - 🍻 to @wang_guoxun an exceptional postdoc w/an exceptional eye & @TiffanyReeseLab - a cool story to be part of along w/@OrchardLab_Rob #mitochondria #mimics #ohmy @utswimmuno @utswnews nature.com/articles/s41586-0…

Norovirus MLKL-like protein initiates cell death to induce viral egress

Nature - The murine norovirus NTPase NS3 induces mitochondrial disruption, resulting in cell death, which is required for viral egress.

nature.com
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Imprinting in placenta via nanopore. Worth a read if you're into that sort of thing! Gratitude to all involved, foremost the co-lead authors Michalea Kindlova and Hannah Byrne (no twitter afaik). Many thanks to @QLDFamilyCohort for making this possible. biorxiv.org/content/10.1101/…

An allele-resolved nanopore-guided tour of the human placental methylome

The placenta is a temporary organ present during pregnancy that is responsible for coordinating all aspects of pregnancy between the mother and fetus. It has a distinct epigenetic, transcriptomic,...

biorxiv.org
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Obituary: Haig Kazazian and Horizontal Transfer (1937 – 2022) dlvr.it/Sg4kQK

Obituary: Haig Kazazian and Horizontal Transfer (1937 – 2022)

Mobile DNA -

link.springer.com
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Binfie opportunity. Senior Research Fellow, Level C @MonashCCS @ACBDresearch @MonashUni work with a great team @MonashBioinfo . Make a difference and #changeIt Details here: careers.pageuppeople.com/513…
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Academics are like the kid who tries to fit the whole bag of marshmallows in their mouth, except with projects
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🧬Excited to share that the 2nd story out of my PhD is now on bioRxiv!🧬We resolved locus-specific methylation dynamics of the monomeric mouse L1 promoter during development using bisulfite & nanopore sequencing! w/ @RichardsonL1Lab @Faulkner_Lab 👇 1/6 biorxiv.org/content/10.1101/…

Mouse L1s fade with age: a methylation-enforced mechanism for attenuation of L1 retrotransposition...

Mice harbor ∼2,800 intact copies of the retrotransposon Long Interspersed Element 1 (L1). The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity and epigene...

biorxiv.org
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Postdoc vacancy in my lab in sunny Brisbane - please RT. nature.com/naturecareers/job… You will have or soon have a PhD on mobile DNA or a closely related topic. 3+ years to work together on anything we both find interesting. Start within the next year. Overseas applications welcome.
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