Urology Registrar at Imperial College London NHS Trust; Clinical Research Fellow for IP-10 AVIDITY; GKT/KCL Class of 2020; MBBS BSc MRCS

London, England
Joined May 2018
Fantastic day @ictmc2026 to see novel #AVIDITY and #TRANSFORM trial designs presented by @QMUL collaborators IP10-AVIDITY - efficient random disclosure controlled trial design IP12-TRANSFORM - innovative data-led strategy to widen participation in PCa screening xitter.cf/_Sam_Morris_/status/21…
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IP10-AVIDITY making fantastic progress 👏
New milestone reached! IP10-AVIDITY has now recruited over 50 patients. Congratulations to @royalmarsdenNHS for recruiting the 50th patient 👏
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🎉 Delighted to welcome Sunderland Royal Hospital (@mccrackenstuart, Fraser Barbour) & @FreemanHospital (@rajan_vpillay, James Leighton) to #IP16SCOPE, an international service evaluation on #ActiveSurveillance in #ProstateCancer! 📩Interested? Email us: [email protected]
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🚨NEW PUBLICATION🚨 IB1-LASERCOMPLETE live in @BJUIjournal! @TUF funded prospective feasibility study in bladder cancer: 👉 Can FCM help detrusor muscle detection in TURBT samples 📄 Read it free: doi.org/10.1111/bju.70395 Thank you to the funder, all co-authors and the patients!
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#IP10AVIDITY update after a strong July for recruitment 4⃣0⃣ patients recruited from 2 main sites and 2 PICs New sites opening soon helping to answer PSMA PET clinical utility and cost-effectiveness questions Thanks to all patients and all those involved
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Not surprising - lots of extra (potentially unnecessary) ADT use for tiny glowing spots only seen on PSMA Need to tackle the utility question - IP10-AVIDITY RCT currently strong recruitment @IP_London @_Sam_Morris_ @Connor_Urol
Receipt of prostate-specific membrane antigen positron emission tomography for #ProstateCancer staging was associated with higher initiation rates of androgen receptor pathway inhibitor therapy and increased use of systemic treatment. ja.ma/4bXVb4W
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#IP7 #PACIFIC has recruited its 2️⃣0️⃣0️⃣0️⃣th patient! Well done to all sites involved, and to Southend @MSEHospitals who recruited patient number 2000! Not long to go!
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Congratulations to @NikhilMayor who has been awarded a prestigious and highly competitive @NIHRresearch Doctoral Fellowship! The £500k award provides an opportunity to optimise screening pathways using MRI - including a #ProstateCancer screening study called #RADAR, coming soon!
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First spoke about focal therapy in Radio 4 Today studio in 2012, when our second phase II trial in 42 patients was published in Lancet Oncology, funded by @The_MRC, showing excellent early outcomes. 14 years later, back to talk about longterm outcomes of 3,477 pts @IP_London
A major study suggests focal therapy for prostate cancer is just as effective as surgery or radiotherapy - with a lower risk of side effects. Prof Hashim Ahmed and his patient Paul Sayer, founder of charity Prost8 UK, want greater availability for the less invasive treatment.
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Sam Morris retweeted
Fantastic to see our study covered in page 2 of @thetimes newspaper today!
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✅ Focal therapy for prostate cancer is effective over the long term 🏆A win for all those eligible patients who want a treatment for their significant prostate cancer with fewer side effects 🇬🇧 Amazing ‘Team UK’ endeavour for the last two decades to get us to this point!
🚨 NEW IN @EUplatinum! 🚨 The largest analysis of focal therapy by Imperial Prostate and UK colleagues, reporting 1⃣0⃣-year outcomes after focal HIFU and cryotherapy in 3⃣4⃣7⃣7⃣ men 🔥🧊 Led by @AJWLight @LondonProstate1 @TaimurShah Read for free: europeanurology.com/article/…
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BREAKING NEWS 📰 A less invasive treatment for prostate cancer called focal therapy is just as effective as surgery or radiotherapy, with a lower risk of side effects, a new study has found. The 10-year study, led by @imperialcollege, was supported by us through a doctoral fellowship, our @ImperialBRC and the Imperial Experimental Cancer Medicine Centre. As @PreetKGillMP, Minister for Health Innovation and Safety, said: "Our National Cancer Plan sets out our ambition to transform cancer care, and backing innovations like focal therapy is exactly how we are delivering on that promise." Read more in the @BBCNews coverage ⬇️
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Sam Morris retweeted
A career highlight to lead this study on 10 year outcomes in almost 3500 men undergoing focal therapy, now published in @EUplatinum And fantastic to see the widespread UK media coverage today across TV, radio, and print! Many thanks to my collaborators and mentors 🙏
🚨 NEW IN @EUplatinum! 🚨 The largest analysis of focal therapy by Imperial Prostate and UK colleagues, reporting 1⃣0⃣-year outcomes after focal HIFU and cryotherapy in 3⃣4⃣7⃣7⃣ men 🔥🧊 Led by @AJWLight @LondonProstate1 @TaimurShah Read for free: europeanurology.com/article/…
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#IP2ATLANTA pilot results presented by @Archana_GK1 at #LSS2026 What effect does doublet systemic therapy have on primary tumour in mHSPC? Complete pathological response 11.3% ⬇️ cribriform pattern, EPE & PNI ⬆️ intraductal pattern ⭐️ Main trial results in 2027
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#IP10AVIDITY: @_Sam_Morris_ updated the London Surgical Symposium about the @ProstateUK-funded trial status ➡️ 30 recruits across two full sites and 2 PICs ➡️ Pilot phase into final third of recruitment period Exciting news to come from our other IP presentations today…! 🥇
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#IP2ATLANTA pilot PROMS and local AE data presented at the London Surgical Symposium by @_Sam_Morris_ ➡️ Cytoreductive treatment appeared to be associated with improved urinary symptoms ➡️ Offset by modest increase in pad usage after radical treatments Full results due 2027
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Replying to @Archana_GK1
@Archana_GK1 presented local 5-year #RAPID pathway #ActiveSurveillance outcomes ➡️ ~50% treatment rate within 5 years, with more treatment in GG2 patients than GG1 ➡️ Treatment triggers are heterogenous ➡️ Active surveillance needs improvement #LSS2026 #prostatecancer #urology
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Replying to @uz1_033
@uz1_033 presented his BSc work on the clinicopathological characteristics of patients with non-expression of PSMA at primary staging in cases of adenocarcinoma before initiation of ADT ➡️8.2% of tumours were non-avid ➡️non-avid tumours had lower PSAs Well done, Usman 👏
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Great to be presenting our work at the London Surgical Symposium today, with 2️⃣ podium presentations and 5️⃣ posters by @Archana_GK1, @_Sam_Morris_ and BSc student Usman Stay tuned for 🔑 messages!
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It's been an excellent month for recruitment in the #IP10AVIDITY trial with 28 patients now recruited across @ImperialNHS, @royalmarsdenNHS and PIC sites @ChelwestFT and @WestMidHospital. Thanks to all participants and contributors. Exciting news on further sites coming soon!
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