@ZhengLiuLab

Principal investigator@Wuhan University, China. |Previously @salaitalab @ Emory University, US.| We are working on cell mechanics, Single-Molecule biophysics.

zhengliu82.wixsite.com/liulab
Joined December 2017
  • Tweets244
  • Following981
  • Followers425
27Media
Nature CommunicationsのArticle number、2025年12月22日時点の最新番号は11145。2025年1月16日に出た我々の論文は729なので、年間1万報以上出版されているのですね。APCがざっくり1報100万円なので売り上げ100億円ですね。 nature.com/articles/s41467-0… nature.com/articles/s41467-0… nature.com/ncomms/open-acces…

Increased small impactor flux on the Moon as inferred from regolith thickness at the Chang’E-5...

Nature Communications - In this study, the authors study the regolith thickness at the Chang’E-5 region on the Moon. Based on this, they infer an increased small impactor for this area, being...

nature.com
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Macrophages can engulf targets whole (phagocytosis) or nibble them in small fragments (trogocytosis), a decision controlled by cortical tension in the targets (high tension favors former, low latter) nature.com/articles/s41556-0… nature.com/articles/s41556-0… @NatureCellBio @UCBerkeley
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Excited to share our new Nature Protocols paper!
Nature Protocols@NatureProtocols29 Nov 2025
New Article! Measuring cellular force using DNA-based tension probes: from ensemble to single-molecule studies bit.ly/4pGMukf
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Fibroblasts aren’t always slow — by tuning integrin ligand spacing and force-limited bond lifetime, we boost their migration up to 12×. A new 2D framework for adhesion-regulated motility. | PNAS pnas.org/doi/10.1073/pnas.25…
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Happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2–3 nm and resolve sub-10 nm structural features in cells. nature.com/articles/s41592-0… rdcu.be/eQVxt
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Zheng Liu retweeted
Jie Yan@JieYan_NUS18 Sep 2025
📄 Read the full preprint on bioRxiv: 👉biorxiv.org/content/10.1101/…

Dual-mode intramolecular agonist-dependent mechanoactivation of the adhesion GPCR ADGRG1/GPR56

Mechanical stimuli instruct cardinal cellular decisions pertaining to their fate, proliferation, morphology, and movement[1][1],[2][2]. How adhesion G protein-coupled receptors (aGPCRs), a large...

biorxiv.org
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📣 The Springer Lab is hiring! Advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology. timothyspringer.org/news/202… #postdocjobs, #academictwitter, #ECRchat, #phdchat
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Zheng Liu retweeted
Jie Yan@JieYan_NUS30 Aug 2025
🌟 Excited to announce the East Asia Single-Molecule Biophysics Symposium 2025 (EASMB 2025)! 📍 Singapore 🌐 Info & details: physics.nus.edu.sg/easmb2025… 📌 Abstract deadline: Sept 12, 2025 ✉️ Register: [email protected]
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Check it out at PNAS today. Thank you Alexandre for the collaboration!! PK Mem probes offer long time-lapse imaging of cell membrane dynamics. Made possible by @JingLing369, Yitong Liu, and all the collaborators! Available @spirochrome
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex16 Jul 2025
Thrilled to collaborate with @ZhixingChen2 Lab @PKU1898! We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience tiny.cc/3qhp001
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Jie Yan@JieYan_NUS16 Jun 2025
Just shared a review on mechanosensing protein linkages — their roles in force transmission and potential as therapeutic targets. 🔗 pubs.aip.org/aip/apb/article… #Mechanobiology #ProteinEngineering #DrugDiscovery @MBIsg

Decoding force-transmission linkages for therapeutic targeting and engineering

Mechanosensing and mechanotransduction enable cells to perceive and respond to mechanical forces, underpinning essential physiological processes and disease pat

pubs.aip.org
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It’s finally out!!🥳 Check out our paper in @NatureMaterials on a new hybrid scaffold where we discover ECM-specific cues that regulate cardiac aging 🔗 nature.com/articles/s41563-0… This is the lab’s 1st research paper, led by my 1st @NUSBME PhD student @AveryRuiSun🤩 Tweetorial👇
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Isaac Li@IsaacLiLab12 Mar 2025
We just published a review on recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd.2024.28 #mechanobiology
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Our extensive review on "Computational Super-Resolution: An Odyssey in Harnessing Priors to Enhance Optical Microscopy Resolution" is online at pubs.acs.org/doi/10.1021/acs… Wenfeng put a lot of heart and soul into it. So I believe that it is worth reading😀

Computational Super-Resolution: An Odyssey in Harnessing Priors to Enhance Optical Microscopy...

Published as part of Analytical Chemistryspecial issue “Fundamental and Applied Reviews in Analytical Chemistry 2025”.

pubs.acs.org
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We make it to the cover @NatureBiotech! the IL-10-CAR-T cells eradicate solid tumors! nature.com/articles/s41587-0… The IL-10-CD19-CAR-T cells have shown promising clinical results in several investigator initiated trials too. Stay tuned! #SOHC @myESMO @ASH_hematology

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and...

Nature Biotechnology - CAR T cells engineered to express IL-10 eradicate solid tumors and metastases.

nature.com
Nature Biotechnology
@NatureBiotech12 Nov 2024
The November issue is live nature.com/nbt/volumes/42/is… On our cover, Zhao et al. show that expressing IL-10 in CAR T cells improves their mitochondrial function and therapeutic efficacy in multiple solid-tumor models go.nature.com/3vh5Bdv
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Thrilled to share our back-to-back two Nature @Nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ @YugangGUO2 @RongFan8(1/11)
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Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/scie…
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Here we report the DNA Origami Tension Sensor (DOTS) & measure TCR-pMHC forces in cell-cell junctions! Forces measured using microscopy or flow cytometry! @EmoryChem⁩ ⁦@YuesongH⁩ ⁦@salaitalab⁩ ⁦@EmoryUniversity⁩ nature.com/articles/s41565-0…

Quantifying T cell receptor mechanics at membrane junctions using DNA origami tension sensors

Nature Nanotechnology - The authors present nanoscale DNA origami tension sensors tethered to lipid membranes and reveal the magnitude, dynamics and driving mechanisms of molecular forces...

nature.com
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🤩🤩 Feeling a little starstruck hanging out with Sunney Xie!!
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#methods_highlight Lots happening in molecular tension probes! In addition to the work from the Ha lab we highlighted last month, @ZhengLiuLab has a nice paper on DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells. cell.com/cell/abstract/S0092…
Nature Methods@naturemethods20 May 2024
Research Highlight by @rita_strack : TJ Ha @taekjip, Myung Hyun Jo, and colleagues develop a single-molecule method for probing loading rates in mechanical force measurements. Original paper: science.org/doi/10.1126/scie… Highlight: nature.com/articles/s41592-0…
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🚨Our paper on the confined migration of autonomous cell clusters is now out in @NaturePhysics 👏 Wonderful collaboration with @EdouardHannezo @d_brueckner @XavierTrepat and incredible work by @EleonoreVercru with @LucianoMarine1 and @KYohalie @UMONSnews nature.com/articles/s41567-0…
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