@YugangGUO2
Joined May 2021
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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases go.nature.com/3vh5Bdv
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Interested in working on the next generation of cancer immunotherapies? The Tang Lab at the Swiss Federal Institute of Technology in Lausanne is looking for a postdoctoral researcher with a strong background in immunology, metabolism, and mouse studies. See below for more info ⬇️
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Thanks Pr. Richard Klemke for highlighting our work in Faculty Opinions. "Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity"- recommended in @FacultyOpinions facultyopinions.com/prime/74…
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Thank ACIR for nice report for our work. acir.org/weekly-digests/2021…

IL-10 rejuvenates your exhausted T cells

While immunotherapies work great in some patients, for most, results are limited. One reason for the limited therapeutic response is the induction of an “exhausted” phenotype in CD8+ TILs. Aiming to...

acir.org
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Our lab's new paper (rdcu.be/clkR2) on metabolic reprogramming of exhausted CD8+ T cells is now out at @natureimmunology, highlighted as a cover story! (1/7)
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#cancer Tang and colleagues show that a half-life-extended IL-10–Fc fusion protein enhances proliferation and effector function of terminally exhausted T cells via metabolic reprogramming which can eradicate established solid tumors in mice.rdcu.be/cld9s
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