Scientist.
Cardiff, UK
Joined April 2010
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Excited to share our new paper led by Maria Sharif and in collaboration with Prof. Ben Wilcox. We reveal how ProPAgens activate Vγ9Vδ2 T cells and show potent anti-tumour activity in colorectal cancer organoids.
LINK: pubs.acs.org/aptsfn/article/…
Fully funded PhD studentship available in my lab in Cardiff University.
- Most suitable for candidates with interest in medicinal chemistry and drug discovery.
- Closing date: 21/03/2025.
- Contact me for enquiries.
@PharmacyCU
findaphd.com/phds/project/a-…
Happy to share that our paper looking into the role of OSR1 kinase in promoting breast cancer oncogenic potential is now out. @PharmacyCU
pubs.acs.org/doi/10.1021/acs…
Youcef Mehellou retweeted
Great news - Accession receive MHRA approval for first in human clinical trial of TROCEPT-01 across six UK sites in a range of recalcitrant tumour types. Fantastic to see an agent initially developed @cardiffuni in my @virustinkerer make it to clinic.
mailchi.mp/9425dbf8fce8/acce…
Youcef Mehellou retweeted
Very sad news of the passing of @sirfrasersays, a giant of chemistry for four decades. He pioneered (with J-P Sauvage) the chemistry of the mechanical bond (catenanes & rotaxanes) & recognised that their well defined motions could be useful for molecular machinery... 1/3
Youcef Mehellou retweeted
Post-doctoral fellow position for 3 years on the structural biology of signaling complexes downstream of LRRK2 kinase, in the lab of Amir Khan, Dublin, Ireland. This is a collaborative position with Dario Alessi at the MRC PPU, Dundee, Scotland ppu.mrc.ac.uk/careers/recrui…
Youcef Mehellou retweeted
New opportunity for a Lecturer (Assistant Professor) in Chemical Biology at the University of Bath! bath.ac.uk/jobs/Vacancy.aspx…
Youcef Mehellou retweeted
📢In this year's GPhC registration exam, our graduates performed top in the UK with a pass rate at first attempt of 93%. We're very proud of their achievements! 🎉
Youcef Mehellou retweeted
**MEETING ALERT** @BiochemSoc @ASAP_Research 20th Anniversary meeting on #PINK1 mutations in #Parkinsons. Fantastic lineup of speakers; industry and clinical talks and many early-career speaker slots. To register and learn more click: shorturl.at/LnXZM
Youcef Mehellou retweeted
📢 Two new preprints alert! LRRK2-a kinase associated with #Parkinson’s and #crohn's #IBD. But where is it expressed and active? Not in Paneth cells, important for Crohn’s, but IL-4 induced in B cells, and other immune cells- see tinyurl.com/mwz4py7u tinyurl.com/mpvfhw44
Youcef Mehellou retweeted
“My time at the MRC PPU was truly formative for my scientific career."
@Gerta_Hoxhaj, MRC PPU Alumni & winner of the prestigious 2024 @Vilcek Prize for Creative Promise in Biomedical Science
Full interview on our website: ppu.mrc.ac.uk/about-us/alumn…
Youcef Mehellou retweeted
The landscape of small-molecule prodrugs bit.ly/43I3X1U
This new review analyses approved prodrugs to reveal trends in their development, highlighting design rationales, indications, mechanisms of API release, chemistry of promoieties and the market impact of prodrugs
Youcef Mehellou retweeted
Edrych ymlaen at brynhawn o ymgysylltu ag ysgolion Grangetown a @YoucefMehellou fel rhan o wythnos Gyrfaoedd a Modelau Rôl!
Looking forward to an afternoon of engagement with the schools of Grangetown and @YoucefMehellou as part of Careers and Role Models week!
#STEM
What an away win for Cardiff City U14 basketball team today! Great move from Teilo 🔥 @BrgVibe
Youcef Mehellou retweeted
A few years back I started a journey to learn more about biopharma and drug discovery. Here is a list of the books I have found helpful (loosely grouped by topic) with the outstanding books highlighted by (+++). Feel free to add your own recommendations, I'll keep adding mine.
Youcef Mehellou retweeted
Out Now! Our new preprint of mechanism of #PINK1 activation at TOM complex. Led by Wale @waleraimi & Hina @mrcppu Fantastic collaboration with @ruferbus Sebastian Mathea @ASAP_Research Karim Labib @naranson @TDDeego. #OpenScience click here surl.li/oqvpt
Youcef Mehellou retweeted
Excited to share our work on @ACSCentSci! We used acetlylysine to replace Lys73 of OXA-48 and showed NaCl altered the antibiotic effectiveness by promoting a newly discovered inactive acyl-enzyme intermediate.@YuanHe_NWU @the100footpole @JinGroupMIB pubs.acs.org/doi/10.1021/acs…
Youcef Mehellou retweeted
Far too many cancers are detected late, when treatment may be less effective. A new @theNCI-supported study estimates the # of lives that could be saved if more people receive currently recommended cancer screening. go.nih.gov/2Waw97y #CancerScreenWeek
ALT A bar chart titled “Number of cancer-specific deaths averted per 100,000 eligible for screening*” showing the estimated deaths averted for lung, lung (plus smoking cessation program), colorectal, breast, and cervical cancers. *The numbers are estimated/modeled based on a 10-percentage point increase in USPSTF recommended screening strategies. The data are from Knudsen A, et al. JAMA Network Open. November 22, 2023.
THIS.
Researchers identify age-dependent, brain region-, & cell type-specific effects AND determine expression levels & extent of basal & maximal activation of #Parkinsons-associated PINK1 & PRKN in patient-derived cell models & rodent brains
tandfonline.com/doi/full/10.…
