Yissachar lab at BIU, led by Prof. Nissan Yissachar, study intestinal neuro-immune-microbiome communications, in health and disease.
Bar-Ilan University, Israel
Joined February 2020
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Just published! @NatureComms
We built an optogenetic gut platform that activates specific enteric neurons with light.
Our “second brain” is more influential than we thought - its firing patterns shape immunity, barrier strength, and microbial responses! nature.com/articles/s41467-0…
YissacharLab retweeted
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 nature.com/articles/s41586-0…
🧵👇
YissacharLab retweeted
🚨🚨I’m excited to present our lab’s new paper where we tried to provide a mechanistic explanation for the link between antibiotic use and risk of developing inflammatory bowel diseases (#IBD). A 🧵/1
science.org/doi/10.1126/scia…
YissacharLab retweeted
We are nearly at capacity. Please register to save your spot. Reminder: this meeting is free of charge. @KorenLab @YissacharLab forms.office.com/r/Ny9m00jhC…
YissacharLab retweeted
Back to popular demand, the Microbiome Israel Workshop!🦠🧫 This lineup is unbelievable! All microbiomes included! @KorenLab @YissacharLab @SuezLab @EranElinav @finkel_omri @MoranYassour @YaelLitvak @amiyaal @Naama_GZ @EranBlacher @StraussmanR @LabMizrahi
YissacharLab retweeted
Wow! Blown away by @YissacharLab's talk at #IIS 🤯 showing how optogenetic activation of different neurons the enteric nervous system shapes the immune response. Read his fantastic paper about it: biorxiv.org/content/10.1101/…
Check out our new pre-print! 🎉
We developed a powerful platform to dissect enteric neuroimmune connections using whole-tissue optogenetics on-a-chip. We revealed neuronal-specific activity patterns that differentially regulate intestinal immunity.
biorxiv.org/content/10.1101/…
YissacharLab retweeted
And it's out "The maternal gut microbiome in pregnancy: implications for the developing immune system". Thank you for a fun writing experience @mcarmen_collado @LizaKonnikova @MysorekarLab @BrodinPetter @NatRevGastroHep @biumedicine nature.com/articles/s41575-0…
YissacharLab retweeted
100+ @Harvard post-doc alumni in a letter to Harvard board:
“We no longer share a sense of pride in being Harvard alumni. We are reluctant to recommend to our top students to pursue education at Harvard, as its high academic standards are obscured by low moral standards.”
Fantastic opportunity for post-doc in Israel!
Contact us if you are fascinated by host-microbiome research! yissacharlab.com
Applications for the 2024-25 Azrieli Int’l #Postdoctoral #Fellowship are OPEN! Apply by Nov 15 to be considered for a postdoc position at a top academic institution in Israel – available to candidates worldwide.
Learn more: bit.ly/3YSBmV7
#CallforApplications
Such an elegant study - congratulations Kobi and the team!!!
We are very happy to share our lates publication in @Nature, spearheaded by Tal Givony &Yael Goldfarb, expanding the incredible cellular & functional diversity of mTECs and bringing key insights into the roles of thymic microfold and endocrine cells nature.com/articles/s41586-0…
Finally out!! 🎉
Gut microbes and metabolites control epithelial barrier functions.
Now, we can visualize microbiome-induced changes to gut permeability in real-time!
Thanks @EranElinav @Elinav_Lab for a fruitful and fun collaboration!
@Nature_NPJ
nature.com/articles/s41522-0…
YissacharLab retweeted
Our new review with @FAO is out. We provide an overview of the interrelationships between the microbiome and nutrition in child growth and healthy development and discuss the potential of the microbiome in undernutrition interventions.
nature.com/articles/s41467-0…
Fantastic!!
🚨🚨 Gather ‘round children, it’s Bel lab story time! This one is called “tricking the trickster”. It tells the story of how we found a way to foil the evil plans of the master manipulator, Salmonella typhimurium. A 🧵 /1
biorxiv.org/content/10.1101/…
Excellent opportunity for outstanding postdoctoral researchers!
Apply to the prestigious Azrieli fellows program @azrielifdn and join us to dissect host-microbiome interactions in health and disease @yissacharlab
📣 Our Fellows Program has launched its #CallforApplications for the 2024-25 Azrieli International #Postdoctoral #Fellowship! Candidates worldwide are eligible to apply beginning Sept 1, 2023.
Learn more: azrielifoundation.org/the-az…
ALT Group of International Fellows posing and smiling with the Azrieli Fellows team.
YissacharLab retweeted
So excited for this story on IgA deficiency to be out at @SciImmunology ! Great collaboration with @henricksonlab. We were curious why most kids with IgA deficiency were not symptomatic. What exactly is IgA doing for the mucosal and systemic immunity? dx.doi.org/10.1126/sciimmuno…
YissacharLab retweeted
An amazing collaboration with @SItzkovitz led by @AdiEgozi and @BunmiOlaloye. One step closer to world without NEC. #NEC @YalePediatrics @YaleMed @WeizmannScience. #PLOSBiology: Single-cell atlas of the human neonatal small intestine affected by NEC dx.plos.org/10.1371/journal.…
YissacharLab retweeted
Do helminths exploit the plasticity of the intestinal epithelium to their benefit? @WORMoholic suggests they do!
authors.elsevier.com/c/1gwts…
YissacharLab retweeted
🦠Excited to share our new #preprint studying bacterial #DNAinversions in inflammatory bowel diseases #IBD, in patients and mice, with implications on the host #immunesystem. #microbiome #inflammation #bacteriophages 🧵1/8 biorxiv.org/cgi/content/shor…