@YMerbl

Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology

 Weizmann Institue of Science
yifatmerbl.com
Joined August 2018
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🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology 🔗 nature.com/articles/s41586-0… 🧵👇
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🙏I’m deeply humbled to be included in Nature’s 10 for 2025. Grateful to my lab members, mentors, colleagues at Weizmann, and to my family and friends for their constant support. Our journey began with a small anomaly in the proteasome, a signal that revealed an unexpected layer of immune regulation. Excited for what lies ahead and committed to translating these insights to benefit human health. @NaturePortfolio @WeizmannScience @ERC_Research @CancerResearch @ICRFONLINE @icrf_toronto nature.com/articles/d41586-0…

Nature’s 10: Ten people who shaped science in 2025

A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10.

nature.com
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Let’s not just hope — let’s act — for a future of peace and dignity for all. Violence and hatred must end. Humanity must lead, and science must light the way. 🙏💫🙏 nature.com/articles/d41586-0…

How we’re rebuilding the Weizmann Institute — and our hopes for a better future

Nature - Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.

nature.com
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Humbled and honored 🫣
Samuel Hume
@DrSamuelBHume
10 Mar 2025
Replying to @YMerbl
You are welcome, your paper is completely fascinating
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Yifat Merbl lab retweeted
Samuel Hume
@DrSamuelBHume
10 Mar 2025
Replying to @YMerbl
You are welcome, your paper is completely fascinating
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Thank you for this amazing highlight of our work 🙏🙏🙏
Samuel Hume
@DrSamuelBHume
9 Mar 2025
Top 5 advances in medicine this week (🧵) 1. An untapped treasure trove of antibiotics The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics The top hit is a peptide derived from a serine/threonine phosphatase This peptide kills a range of bacteria, including Pseudomonas and E. coli, and stopped mice dying from sepsis just as well as a conventional antibiotic Study: nature.com/articles/s41586-0… Comment: nature.com/articles/d41586-0…
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Yifat Merbl lab retweeted
Waggoner Lab@LabWaggoner
5 Mar 2025
Protein waste turned into antibiotics in the proteasome as a innate defense strategy of human cells @Nature @WeizmannScience @KarinGoldberg5 @YMerbl nature.com/articles/s41586-0… @NatureNV by @clausen_lab nature.com/articles/d41586-0…
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A big thank you to Tim Clausen (@clausen_lab) for writing such a thoughtful N&V about our recent paper! nature.com/articles/d41586-0…
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Thank you for the shout-out 🙏 and for the @ERC_Research's ongoing support! @WeizmannScience
European Research Council (ERC)
@ERC_Research
6 Mar 2025
🆕 way to fight resistant superbugs? 🦠 ERC grantee @YMerbl and team @WeizmannScience revealed a secret defence in the immune system - reshaping our understanding of infection protection. 👉 bbc.in/3DnLBKL 👉 go.nature.com/3XvSX5Q @Sys_Immunology #Immunology
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Excited to see our work covered @BBCNews. Thank you  @JamesTGallagher for covering it 🙏🙏🙏 bbc.com/news/articles/cpv4jw…

Scientists discover new part of the immune system

New part of the immune system - hidden inside our bodies - could be used to make new antibiotics.

bbc.com
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4/ We hope these findings contribute to a better understanding of innate immunity, and open up exciting possibilities for developing new therapeutic strategies against infections, particularly in the face of rising antibiotic resistance.🔬✨
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5/ This discovery was led by the incredible @KarinGoldberg5 and the amazing support of other team members - highlighting the meaning of teamwork. A huge shoutout to our fantastic collaborators Gee W. Lau, Nissan Yissachar, and Zvi Hayouka.
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Yifat Merbl lab retweeted
ElinavLab@Elinav_Lab
20 Jan 2025
1/14 Excited to share our new @Elinav_Lab @Elinav_DKFZ @WeizmannScience paper @CellCellPress, championed (for 6 years!) by the amazing @rvaldesmas, @AvnerLeshem, @DanpingZheng and twitter-less Alon Savidor. In this work, we’ve adopted into microbiome.. cell.com/cell/fulltext/S0092…

Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers...

A metagenome-informed metaproteomics approach unravels the interplay between the host, gut microbiome, and diet in animal models as well as in human cohorts and identifies disease biomarkers of...

cell.com
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Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from ⁦@werner_achim⁩ Kai Gallant from ⁦@MalteGersch⁩ and Chatrin Chatrin from ⁦@IvanAhelLab⁩ Well done! 👏💫🏆 ⁦@YKulathu⁩ ⁦@polosimona1⁩ ⁦@LabJoazeiro⁩
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it’s a wrap- thank you all 🙏 Such high energies following a meeting with great science, amazing people and beautiful views 🤩🥂💃🕺💫#EMBOubiquitin24
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Fascinating talk by Andrea Murachelli who defined a structure of BRCA1-A with a novel metallo-DUB Inhibitor #EMBOubiquitin24
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We started the last session on UPS therapeutics with a great talk by Stefan Müller @IBC2_GU on SUMO-UB network in stress mediated aggregation #EMBOubiquitin24
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