Associate Professor at ShanghaiTech University | Neural organoids

Shanghai, China
Joined October 2013
Self-organizing neural organoids recreate the coordinated development of the spinal cord and peripheral sensory nervous system, enabling studies of development, disease, and drug effects. 🧫 More on the study: bit.ly/3VMIpB2 🎧 Listen now: bit.ly/47euMgv
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Thank you to @stemcellpodcast for featuring our recent study published in Developmental Cell. A couple of days ago, I watched a live recording of the Stem Cell Podcast for the first time. It was a really enjoyable experience.
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Glad to be invited by the @AllenInstitute, @ISSCR and @SocDevBio to visit Allen Institute for symposium. The commitment of the Institute and societies to supporting early-career researchers, irrespective of nationality, is impressive.
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Yangfei Xiang retweeted
Hosting a Mini-Organoid Symposium at #HKUMed with Gui-Wei He (SZ Bay Lab)! 🗓Sept 30, 1–4pm 📍3SR-LT2, 3 Sassoon Rd, HK Gut, brain, heart, liver & cancer organoids. Speakers: Nick Barker, Yangfei Xiang, Joe Zhang, Gui-Wei He & Rio Sugimura. All welcome! #Organoids
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Glad to share our work published in DC. This study developed a method that enables simultaneous derivation and self-organized co-development of central and peripheral neural tissues, providing a new platform for studying neurodevelopmental disorders and drug evaluation.
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Glad to share our latest preprint study: Human hindbrain organoids with segment-specific 5-HT neurons for motor modulation biorxiv.org/content/10.64898…
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🚨 New method alert! @ShanghaiTechUni researchers report a method to differentiate #hPSCs into 3D #NeuralOrganoids that resemble peripheral sympathetic ganglia, producing both neurons and glial cells of the ganglia in a self-organized manner: bit.ly/4pHS9GX
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3/4 These models can facilitate future research into human sympathetic ganglia and cardiac innervation, encompassing studies on regulatory factors, risk factors, and potential interventions.
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2/4 We also developed a system to reconstruct functional connections between the human sympathetic ganglion and the heart, and found that inter-tissue crosstalk promote the development of both human sympathetic and cardiac tissues.
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1/4 In this study, we achieved self-organized and enriched production of human sympathetic lineages in 3D culture. Sympathetic neurons and satellite glial cells were generated robustly and exhibited long-term structural and functional development.
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Looking forward to sharing our latest research progress at the conference.
Free online registration for Cell and gene therapies for neurological conditions: From bench to bedside | December 10-11, 2025 hubs.li/Q03VNNfm0 @MedCellPress @CellRepMed @NeuroCellPress @CellReports
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ShanghaiTech University scientists describe the generation of 3D, neuromusculoskeletal tri-tissue #organoids from human #pluripotent stem cells through a co-development strategy. 🧫 🔗 Get the full story in @CellStemCell! bit.ly/4fbsRef
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There is no need to separately differentiate and co-culture different lineages, which will facilitate future applications.
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Congratulations to my three PhD students (Yin Yao, Zhou Wei, and Zhu Jinkui). Thanks to all who have helped us in this process.
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I’m glad to share that our recent study on human SpV organoids has been featured on the cover of the October issue of @CellStemCell!
Our October issue is live! The cover features a story from @Yangfei_Lab making human medullary spinal trigeminal nucleus organoids, the information hub of the brain. Other highlights include a Review from @Marta_Shahbazi @vincentpasque on human development and embryo models, @leo_jwu on barriers to interspecies chimerism, @boroviak_lab comparing trophoblast stem cells across species, and more! cell.com/issue/S1934-5909(23…
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