Mitochondrial research at the Division for Molecular Metabolism, Karolinska Institute @wredenberglab.bsky.social
Stockholm, Sweden
Joined August 2020
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WredenbergLab retweeted
Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA.
academic.oup.com/nar/article…
WredenbergLab retweeted
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
nature.com/articles/s41586-0…
WredenbergLab retweeted
Check out our recent paper showing how maternal inheritance of mtDNA is guaranteed in D. melanogaster.
Hansong Ma and coworkers identify POLDIP2 as a novel mitochondrial exonuclease interacting with CLPX protease and promoting elimination of paternal mtDNA during Drosophila spermatogenesis
embopress.org/doi/full/10.10…
WredenbergLab retweeted
I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others.
rdcu.be/d5ACF
#mitochondria
#HHMINews
WredenbergLab retweeted
The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments!
nature.com/articles/s41594-0…
See also the very nice related work by @BMartinHallberg @no1gv: embopress.org/doi/full/10.10…
Happy to share a new preprint, in which we describe the mechanism of human tRNA 3' processing. We show why the RNase Z ELAC2 acts as a monomer in the nucleus, but forms a multi-subunit complex in mitochondria. Plase see 🧵 by @BhattaArjun2p for details!
biorxiv.org/content/10.1101/…
WredenbergLab retweeted
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
WredenbergLab retweeted
Extremely proud to share our integrative work on how 'Dissected antiporter modules establish the minimal proton-conducting elements in Complex I' – now out in Nature Comms! Many thanks to @KAWstiftelsen & @Vetenskapsradetfor funding. nature.com/articles/s41467-0…
ALT https://www.nature.com/articles/s41467-024-53194-5
WredenbergLab retweeted
🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: academic.oup.com/nar/article…
WredenbergLab retweeted
We are excited to share our lab's first preprint, highlighting the role of the CHCHD2-CHCHD10 complex in preserving tissue homeostasis.
A huge thank you to all our collaborators!
biorxiv.org/content/10.1101/…
WredenbergLab retweeted
Exciting new study from the Rorbach lab reveals GTPBP8 as a crucial GTPase in mitochondrial translation and mitoribosome assembly. Huge congratulations to Miriam Cipullo, the driving force behind this research, and the entire team and collaborators!
nature.com/articles/s41467-0…
WredenbergLab retweeted
New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression:
academic.oup.com/nar/advance…
Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
WredenbergLab retweeted
Our mechanistic insights on human 3′-tRNA maturation by the RNAse Z complex are now on bioRxiv!
biorxiv.org/content/10.1101/…. The main findings follow:
WredenbergLab retweeted
Our study is finally out! nature.com/articles/s41531-0…
We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient.
Thanks to @mitopinionated , @LabMotori, @perlmannlab and Per Svenningsson for the great collaboration!
WredenbergLab retweeted
Read our new study: nature.com/articles/s42255-0…
Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.
WredenbergLab retweeted
Happy to share a new preprint, in which we describe the mechanism of human tRNA 3' processing. We show why the RNase Z ELAC2 acts as a monomer in the nucleus, but forms a multi-subunit complex in mitochondria. Plase see 🧵 by @BhattaArjun2p for details!
biorxiv.org/content/10.1101/…
WredenbergLab retweeted
Very happy to share our new article of the interaction of mitochondria, innate immunity and viral infections and the relevance for brain &liver disease. Impressive work by @KangYilin. Thanks @hepojoki @Olli_Vapalahti and all collabs! @helsinkiuni @ASW_lab rdcu.be/dDx2G
WredenbergLab retweeted
Join us 19th-23rd of May 2024 for an exciting #EMBO Workshop in Jozefów, Poland:
𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐌𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐆𝐞𝐧𝐞 𝐌𝐚𝐢𝐧𝐭𝐞𝐧𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐄𝐱𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧
Registration open now!
meetings.embo.org/event/24-m…
WredenbergLab retweeted
This week, postdocs @RubalDiana and @ruth_icg from @mitopinionated Lab and @WredenbergLab represented the division and brought data from the mitochondrial gene expression field with selected talks at #RNAUK2024
WredenbergLab retweeted
Delighted to share new study by Tslil Ast now @WeizmannScience w/ Y. Itoh, D. Suess, @A_Amunts showing (1) the Fe-S proteome is destabilized w/frataxin loss, (2) mitoribosome assembly factor METTL17 harbors a 4Fe-4S cluster, serving as an Fe-S checkpoint for mito translation.
WredenbergLab retweeted
Hypoxia rescue (& hyperoxia sensitivity) of mito CI mutants is evolutionary conserved! Harnessing the power of worm genetics, Josh Meisel w/ @gary_ruvkun discovers “hypoxia mimetic” and “hypoxia resistant” mutants, yielding key mechanisms. cell.com/cell/fulltext/S0092…
