Host-pathogen-microbiota interactions lab @Helmholtz_HIRI @Uni_WUE . We love everything RNA! Tweets by Alex (-AW) or other lab members (-Lab).
Würzburg, Germany
Joined July 2020
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Is it anything Hfq-like (RNA chaperone)? Or similar to CsrA (global translation modulator)? We don't know yet. But as it stands, Bacteroidota RRM proteins appear as excellent candidates to map post-transcriptional networks in gut microbiota species. nature.com/articles/s41467-0…
Westermann lab retweeted
We are all living in a bubble that deprives us of experiences needed to understand the true magnitude of the threat posed by the rise of multi-drug resistant infections. It would be wise to allocate resources that match the severity of the threat.
science.org/doi/10.1126/scie…
Westermann lab retweeted
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Please mark your calendars for the 8th Conference on Regulating with RNA in Bacteria and Archaea! The meeting will be held September 1 - 4, 2025, at the Strasbourg Convention Centre, Strasbourg, France 🇫🇷.
We are very excited and hope to see as many of you as possible!
Westermann lab retweeted
We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover journals.asm.org/doi/10.1128…
Last month, Gianluca Prezza (@prezzag) from the lab very successfully defended his PhD. 🎓Congratulations, Gianluca!!!
While we will sorely miss you, we wish you the best of luck for your future endeavors with @ProfTomEllis. (-AW)
Westermann lab retweeted
A small RNA derived from the 5' end of the IS200 tnpA transcript regulates multiple virulence pathways in Salmonella Typhimurium biorxiv.org/cgi/content/shor… #biorxiv_molbio
Westermann lab retweeted
Happy to share the results of last 5 years' work in #Klebsiella. By performing iRIL-seq in hypervirulent K. pneumoniae (HvKP ATCC 43816), we discover that ArcZ is a core sRNA inhibitor of capsule & virulence, and that its target gene mlaA is a key virulence factor of hvKP in mice
RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Westermann lab retweeted
@lab_rudel introduces the basic concept of @CRC_DECIDE at #DGHMVAAM2024 after two great keynotes by @AndreasPeschel1 and Mathias Hornef: 3 key decisions determine outcome of human infection!
Westermann lab retweeted
Interested in RNA-targeting antisense technologies to manipulate and kill bacteria? Come join us in Würzburg this September -- registration is open (and free!) helmholtz-hiri.de/en/asobiot…
Westermann lab retweeted
Check out our newest manuscript published today in Cell Host & Microbe cell.com/cell-host-microbe/f…
Westermann lab retweeted
If you ever wondered why your favorite enteric bacterium does not grow well on a particular carbon source, despite carrying all the genes required for uptake & catabolism, this thread is for you ‼️ @PLOSGenetics
Westermann lab retweeted
Very excited to finally see our study of global RNA stability in Salmonella out today in
@PNASnews, where we use Bayesian statistical modeling to show bacterial transcripts have subminute half-lives, far shorter than previously thought. pnas.org/doi/10.1073/pnas.23… 1/n
Westermann lab retweeted
Over the moon that the DFG is establishing a priority programme to elucidate gene functions in the human gut microbiome. I am delighted to be coordinating this programme with @TypasLab, @JoergLab and @baerboletta. Exciting science to come!
dfg.de/de/service/presse/pre…
5/5: Sharing our discoveries with the world! 🌍 Our data, now publicly accessible via Theta-Base (micromix.helmholtz-hiri.de/b…), serve as a valuable resource for the microbiome research community, fueling further exploration into the fascinating world of gut bacteria.
4/5: What's MasB up to? 🤔 Using MS2 affinity purification and RNA-seq, we identify MasB's target and explore its impact on bacterial phenotypes. #MasB #GeneRegulation
3/5: Small RNAs (sRNAs) play big roles! 🎵 By expanding the annotation of sRNAs and integrating transcriptomic & functional genomics data, we pinpoint conditionally important ones like MasB, crucial for regulating tetracycline tolerance. #sRNAs #AntibioticResistance
2/5: Unraveling bacterial adaptation mechanisms! 🦠We identify stress- and carbon source-specific transcriptional regulons, shedding light on how B. thetaiotaomicron thrives in the dynamic environment of the human gut. #BacterialAdaptation #TranscriptionalRegulation
1/5: Molecular intricacies of gut bacteria! 🧬 Our study in @NatureMicrobiol , with colleagues from @Helmholtz_HIRI, @DeutschbauerLab , & @LBarquist groups, unveils B. thetaiotaomicron's transcriptional landscape across 15 gut conditions. nature.com/articles/s41564-0…
