Host-pathogen-microbiota interactions lab @Helmholtz_HIRI @Uni_WUE . We love everything RNA! Tweets by Alex (-AW) or other lab members (-Lab).
Würzburg, Germany
Joined July 2020
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Westermann lab retweeted
We are all living in a bubble that deprives us of experiences needed to understand the true magnitude of the threat posed by the rise of multi-drug resistant infections. It would be wise to allocate resources that match the severity of the threat.
science.org/doi/10.1126/scie…
Westermann lab retweeted
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Please mark your calendars for the 8th Conference on Regulating with RNA in Bacteria and Archaea! The meeting will be held September 1 - 4, 2025, at the Strasbourg Convention Centre, Strasbourg, France 🇫🇷.
We are very excited and hope to see as many of you as possible!
Westermann lab retweeted
We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover journals.asm.org/doi/10.1128…
Westermann lab retweeted
A small RNA derived from the 5' end of the IS200 tnpA transcript regulates multiple virulence pathways in Salmonella Typhimurium biorxiv.org/cgi/content/shor… #biorxiv_molbio
Westermann lab retweeted
Happy to share the results of last 5 years' work in #Klebsiella. By performing iRIL-seq in hypervirulent K. pneumoniae (HvKP ATCC 43816), we discover that ArcZ is a core sRNA inhibitor of capsule & virulence, and that its target gene mlaA is a key virulence factor of hvKP in mice
RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Westermann lab retweeted
@lab_rudel introduces the basic concept of @CRC_DECIDE at #DGHMVAAM2024 after two great keynotes by @AndreasPeschel1 and Mathias Hornef: 3 key decisions determine outcome of human infection!
Westermann lab retweeted
Interested in RNA-targeting antisense technologies to manipulate and kill bacteria? Come join us in Würzburg this September -- registration is open (and free!) helmholtz-hiri.de/en/asobiot…
Westermann lab retweeted
The RNA landscape of the human commensal Segatella copri reveals a small RNA essential for gut colonization biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Westermann lab retweeted
Check out our newest manuscript published today in Cell Host & Microbe cell.com/cell-host-microbe/f…
Westermann lab retweeted
If you ever wondered why your favorite enteric bacterium does not grow well on a particular carbon source, despite carrying all the genes required for uptake & catabolism, this thread is for you ‼️ @PLOSGenetics
Westermann lab retweeted
Very excited to finally see our study of global RNA stability in Salmonella out today in
@PNASnews, where we use Bayesian statistical modeling to show bacterial transcripts have subminute half-lives, far shorter than previously thought. pnas.org/doi/10.1073/pnas.23… 1/n
Westermann lab retweeted
Over the moon that the DFG is establishing a priority programme to elucidate gene functions in the human gut microbiome. I am delighted to be coordinating this programme with @TypasLab, @JoergLab and @baerboletta. Exciting science to come!
dfg.de/de/service/presse/pre…
Westermann lab retweeted
Looking for an exciting PhD or Postdoc oportunity in microbiology? We are hiring at all levels! More than glad to discuss, just reach out brochadolab.com
🚨HIRING
We are stacking up and added for the newly established wonderful @AnaRitaBrochad1 Lab:
2 #postdocposition
1 #PhD position
1 Technical Assistant position (BTA/CTA/MTA)
Have a look here and apply for one of our 13 positions
cmfi.uni-tuebingen.de/en/car…
Please share!
Westermann lab retweeted
Explore the fascinating world of bacteriophages with this @NatureMicrobiol paper.🌍🦠@JoergLab @Milan_Gerovac @RobLavigne1 @BoettcherCryoEM @Ko_chihara @laura241192 discovered that phage proteins target & co-opt host ribosomes immediately upon infection. Congrats to all authors!
Jumbo phage proteins co-opt host ribosomes immediately upon infection. We provide a resource for complexes in PhiKZ-infected Pseudomonas cells. #PhageDiversity #PhageComplexes @JoergLab @RobLavigne1 @BoettcherCryoEM @Uni_WUE @Helmholtz_HIRI nature.com/articles/s41564-0…
Westermann lab retweeted
Better late than never: Tim Schnyder has accepted the #HIRI Spirit Award. This award is regularly presented to team members who exceptionally promote the HIRI spirit. 👏🏆
ALT Picture of Tim Schnyder. Photo: Helmholtz Institute Würzburg / Luisa Macharowsky
At the #HIRI, we value not only excellent research but also great camaraderie. For this reason, we regularly honor colleagues who are truly dedicated to fostering the HIRI spirit. Congratulations to @katwandu and Tim Schnyder (who couldn't attend the award ceremony)! 🏆🥳
ALT Picture of Katharina Wandera. Photo: Helmholtz Institute Würzburg / Luisa Macharowsky
Westermann lab retweeted
The global RNA–RNA interactome of Klebsiella pneumoniae unveils a small RNA regulator of cell division | PNAS pnas.org/doi/10.1073/pnas.23…
Westermann lab retweeted
#HIRI’s @WestermannLab & @BeiselLab deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. (1/2)
helmholtz-hiri.de/en/newsroo…
ALT Picture of Sarah Reichardt, Alexander Westermann, Gianluca Prezza, and Chase Beisel. Photo: Helmholtz Institute Würzburg / Luisa Macharowsky
Westermann lab retweeted
Fun collaboration with Wulf Blankenfeldt @Helmholtz_HZI! They found a previously overlooked protein that is essential for proline reductase activity in C. difficile and, likely, in other bacteria. biorxiv.org/content/10.1101/…
Westermann lab retweeted
I'm proud to share our new @NatureComms paper on iRIL-seq, an updated and streamlined version of #RIL-seq to map RNA-RNA interactomes in vivo without UV crosslink! We revealed many mRNA regulatory hubs targeted by >=4 sRNAs and a new 3'UTR-sRNA FadZ. rdcu.be/ds2tQ
