Artificial Metalloenzymes Laboratory at @UniBasel_en led by Prof. Thomas R. Ward.
Basel, Switzerland
Joined November 2017
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Check out our recent paper on an enantioselective H atom transfer reaction catalyzed by an artificial metalloenzyme. A big thank you to Dongping and Xiang for this inspiring piece of work. nature.com/articles/s41557-0…
Ward Group retweeted
Large-scale, automated screening and active machine learning can increase the success rate and efficiency of enzyme engineering
NEW #ASAP by @JeschekLab, @arkrause, @WardGroupBS & colleagues
Read it here: go.acs.org/a28
Enzyme repurposing of Carbonic Anhydrase and Myoglogin into… ketoreductases. Check out John Hartwig’s paper in Angewandte Chemie
onlinelibrary.wiley.com/doi/…
And ours in CHEM
sciencedirect.com/science/ar…
Ward Group retweeted
Now online:
News & Views on the Article by Zhi Zou, Thomas R. Ward & co-workers @WardGroupBS @UniBasel_en
nature.com/articles/s44160-0… ($)
Microbial cell factories for cycloalkene synthesis by Ru Jiang & Gerard Roelfes @RoelfesGroup
nature.com/articles/s44160-0… ($)
We have a PhD position opening for a candidate with demonstrated experience in electrochemistry.
We are aiming to immobilize various metalloenzymes for small molecule activation.
See for example: pubs.acs.org/doi/ful
Congrats to Tobias for the nccr tubo grant!
We are glad to announce the recipients of the 2023 #NCCRCatalysis Turbo Grants!
Congratulations to @WeinreichJan from @corminboeuf_lab group, @benedikt_winter and @JoSchllng from @EPSE_ETH group, and @t_vornholt from @WardGroupBS group.
Details here 👉🏻 nccr-catalysis.ch/news/recip…
Ward Group retweeted
Nice work! ✨ nature.com/articles/s41557-0… – at Pully, Suisse
Ward Group retweeted
ever since @barra_lena's work on PLP-mediated catalysis in the biosynthesis of altemicidin, I've been fascinated by PLP. very cool to see this enzymatic pathway intercepted by photoredox-generated radicals!
We published our first paper on pyridoxal radical biocatalysis in @ScienceMagazine : lnkd.in/gkB5dpKM. What we are most excited about is the ability to design general biocatalytic activation modes which are both new-to-biology and new-to-chemistry:
Great collaboration
A big thank you to all contributing colleagues/authors/experts and Jo Richers for a superb title page
Bridging the Gaps: Learning from Catalysis across Boundaries
@NCCR_Catalysis @WardGroupBS
pubs.acs.org/doi/10.1021/acs…
Ward Group retweeted
Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)–H Bonds | JACS @UniBasel_en @WardGroupBS @TotalSyntheses #Metalloenzyme #Enantioselective #Amidation #Nitrene #CHfunctionalization pubs.acs.org/doi/10.1021/jac…
Ward Group retweeted
Celebrating Rudy Marcus’ 100th birthday @Caltech @CaltechCCE @NobelPrize . Still loving #chemistry!!
Ward Group retweeted
We are thrilled to share a new HF-free technology that converts fluorspar to fluorochemicals. Enormous congratulations to the amazing team of chemists who made this recurring dream a reality! science.org/doi/10.1126/scie… @CalumPatel @ScienceMagazine @OxfordChemistry @Fluo_Rok
Ward Group retweeted
This @ACSChemRev was guest edited by #NCCRCatalysis PIs Thomas @WardGroupBS and Christophe @CoperetGroup! The issue focuses on "Bridging the gaps: Learning from Catalysis across Boundaries" - right up our alley! 🧪📑
Read here 👉🏻 doi.org/10.1021/acs.chemrev.…
xitter.cf/CoperetGroup/status/16…
Bridging the Gaps: Learning from Catalysis across Boundaries
@NCCR_Catalysis @WardGroupBS
pubs.acs.org/doi/10.1021/acs…
Anyone interested in joining the Ward group for a PhD? Have a look at euraxess.ec.europa.eu/jobs/8…
and
xitter.cf/MetRaZymes
for an opening as part of an exciting team of European chemists
Ward Group retweeted
JACS online:
An Artificial #Metalloenzyme Based on a #Copper #Heteroscorpionate Enables sp3 C–H #Functionalization via #Intramolecular #Carbene Insertion
@UniBasel_en @WardGroupBS @TotalSynthesis
@J_A_C_S @isciverse @CHNSci @TotalSyntheses
pubs.acs.org/doi/10.1021/jac…
Ward Group retweeted
We reconstitute active artificial hydrogenases using apo-protein of [Fe]-hydrogenase and synthetic Mn complexes. The most active variants appear to operate via a reaction pathway deviated from the native pathway.
onlinelibrary.wiley.com/doi/… @EPFL_CHEM_Tweet @angew_chem
Ward Group retweeted
Metal hydride reductions join the growing family of reactions catalyzed by metalloenzymes! Check out this paper on abiotic reactivity, achieved on a carbonic anhydrase platform.
Kudos to @Jipengfeium, Jeeyoung, and Yang! nature.com/articles/s41557-0…
Looking forward to future collaborations with you!
