@VilledaLab
 San Francisco, CA
VilledaLab.ucsf.edu
Joined November 2018
  • Tweets116
  • Following199
  • Followers1.1K
10Media
Cover story in Immunity! 🎉 Aged CD8+ T cells and their secreted factors drive hippocampal-dependent cognitive decline. Targeting them rescues cognition in old mice, pointing toward future therapeutics for age-related cognitive loss. Congratulations Dr. Juliana Sucharov + team!
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cell.com/immunity/fulltext/S…

Aged circulating CD8+ T cells and their secreted factors drive cognitive decline

The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal...

cell.com
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Wonderful to be able to share this fantastic new work in @biorxivpreprint led by @HerberCharlotte (and in collaboration with @VilledaLab) on how aging impacts spatial coding and memory!
Charlotte Herber@HerberCharlotte
22 Apr 2024
I'm excited to share a preprint reflecting my PhD work with @lisa_giocomo, where we characterized the impact of aging on the medial entorhinal cortex (MEC), a key hub of spatial coding and memory. 🧵below! biorxiv.org/content/10.1101/… (1/11)

Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex

Across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network-level spatial...

biorxiv.org
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Interested in having your own independent lab immediately after graduate school? The UCSF Sandler Fellow Program is now open for applications. Deadline 1/12/24. Please spread words.
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Dena Dubal
@DenaDubal
19 Oct 2023
Amazing meeting, best science and wonderful friends ⁦@SimonsFdn⁩ ⁦@SCAgingBrain. Thx for the pic Saul ⁦@VilledaLab⁩!! ⁦@BrunetLab⁩ ⁦@ctmurphy1⁩ ⁦@JasonSynaptic⁩ ⁦@wysscoray⁩
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Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species @ctmurphy1 @UCSFAging @VilledaLab cell.com/cell-reports/fullte… | @CellReports
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We're proud to announce that @param_p_singh and @DrRohitBose are recipients of the @NIHDirector's New Innovator Award! This award is given to exceptionally innovative early-stage investigators. bit.ly/3rEDpzT #NIHHighRisk
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New work from the lab @NatureAging! 🌱🌱 We asked whether the ability of plants to suppress pathological protein aggregation can be applied into human cell and animal models to delay or even prevent neurodegenerative diseases nature.com/articles/s43587-0…

In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent...

Nature Aging - Unlike animals, plants prevent pathological polyQ aggregation through chloroplast proteostasis. Expression of the chloroplast protein SSP in human cell and nematode models prevents...

nature.com
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Yin Shen@YinShenLab
28 Sep 2023
🌟 Exciting Job Opportunity Alert! 🌟 We are recruiting multiple faculty members @IHG_at_UCSF this year and want to hear from you!
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Have you ever felt stressed about asking questions after a scientific talk? Here I share a few thoughts and tricks that might help you become comfortable in asking questions: valenzano-lab.github.io/docs…
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About time to officially announce that our lab recently moved to @IcahnMountSinai! We are so delighted to join the wonderful community here, and we are looking for postdocs. Come join our team! labs.icahn.mssm.edu/panagiot… Apply here: careers.mountsinai.org/jobs/…

Home - Panagiotakos Laboratory

Welcome to the Panagiotakos Lab at Mount Sinai!neural development | activity | calcium channels | neuropsychiatric disorders of developmental origin We are looking for postdoctoral fellows to join...

labs.icahn.mssm.edu
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nature
@Nature
16 Aug 2023
A protein involved in wound healing can improve learning and memory in ageing mice go.nature.com/47xwitb
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Eric Topol
@EricTopol
16 Aug 2023
An impressive trio of papers makes a strong case for platelet factor 4 (PF4) as the key to reducing inflammation and improving cognition in the aged brain model nature.com/articles/s41586-0… @Nature @VilledaLab @UCSFMedicine @justsaysinmice
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This is a super cool convergence of work coming out of the labs of @DenaDubal @UCSF and Tara Walker @QldBrainInst demonstrating that the same plate factor – PF4 – can rejuvenate cognition in the context of klotho, exercise and young blood! @NatureAging @NatureComms
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Super thrilled to share our most recent work, published today in @Nature! Adam Schroer and Brit Ventura led this tour de force study, which shows that a platelet factor in blood plasma – PF4 – can attenuate inflammation and rescue cognition in aging: nature.com/articles/s41586-0…
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Laura Remesal-Gomez from the @VilledaLab presenting her work identifying FTL1 as a neuronal pro-aging factor that promotes cognitive decline. #BAAM
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science.org/doi/10.1126/scie… Excited to share our new work out today in @ScienceMagazine, led by stellar postdoc Regina @hijaishin! We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

A cholesterol sensor for the growth regulator protein kinase complex mTORC1 is identified.

science.org
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Ever wondered why #exercise is so beneficial for #healthyliving? Looking for your next position? @JonesLabUCSF and @VilledaLab looking for a joint #postdoc to help unlock the secrets🏃🏃! DM me for more info/ Please R/T! @UCSF @UCSFAging 🌉
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#Cancer brain #metastasis manuscript in press @CellCellPress! Special moment @UCSF @HDFCCC around the holidays. Gift to Zena (1945-2020) ❤️. Honored to mentor Hugo, Zena's trainee now in Roose lab. Super job Hugo! Thx @TheMarkFdn. Please RT 🙏. Zena Werb nature.com/articles/s43018-0…
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UC San Francisco@UCSF
4 Oct 2021
New @NobelPrize winner David Julius, PhD, has had an incredible career. Here’s everything you need to know. #UCSFProud ucsf.edu/news/2021/09/421481…

David Julius Wins Nobel Prize for Work on Pain Sensation

David Julius, PhD, professor and chair of the Department of Physiology and Morris Herzstein Chair in Molecular Biology and Medicine at UC San Francisco, has won the 2021 Nobel Prize in Physiology or...

ucsf.edu
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