Automated systems for analyzing, sorting, and dispensing of cells, model organisms #celegans #zebrafish #drosophila #stemcell clusters #organoids #spheroids

Holliston, MA
Joined September 2016
Developmental biologists, Gary Ruvkun & Victor Ambros, @NobelPrize ceremony today. They were honored for their discovery of microRNAs using C elegans. @SocDevBio
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Big couple of days for the team at #AACR24. @mgarnett11 will be presenting *today* on the development of an organoid biobank for dependency mapping. Ballroom 20CD at 13:25. Also, don't miss @GabrielePicco2 tomorrow presenting novel WRN helicase inhibitors.
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Are you interested in #lung and #airway #organoids and 3D cell culture models ๐Ÿงซ? Come and join us on the Lung and Airway Organoid Workshop on the 29th of April @ImpOrganoid @ImperialBRC @ImperialNHLI More info in: imperial.ac.uk/events/175659โ€ฆ
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How to study #islets Spheroid formation enhances physiological function of human clonal beta-cell lines providing surrogates for primary islets in extracellular electrophysiology #diabetes biorxiv.org/content/10.1101/โ€ฆ
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Pawar et al. show that overactive matriptase activates a PAR-2/PI3K/Akt/MMP9 signaling axis to enhance spheroid dissemination and #metastasis in #OvarianCancer. hubs.la/Q02ry_Mz0 From our #Cancer Cell Biology collection: hubs.la/Q02ry-K20 #AACR2024
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Stop by our joint poster session with @Agilent and Dr. Tony Wood from CST at #AACR24: Quantitative Evaluation of Biomarkers for TGF-ฮฒ-Induced Epithelial-Mesenchymal Transition in Biochemical, Cellular, and 3D Spheroid Model Systems. ๐Ÿ—“๏ธ Sunday, April 7, 1:30-5 PM ๐Ÿ“ Poster section 8, board 13 cst-science.com/o73dg6
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Our paper on collective 3-D forces of tumor spheroids (and tumoroids and organoids) is published doi.org/10.7554/eLife.51912 @eLife. The video below shows strange pulsating forces that we see only (why??) in primary luminal B breast carcinoma spheroids.
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๐Ÿ”ฌ Exciting talk at #AACR2024! ๐Ÿ‘ฉโ€๐Ÿ”ฌAlison Taylor, PhD ๐ŸงฌA genome engineering approach using CRISPR-Cas9 genome editing, computational approaches, and organoid models to understand cancer aneuploidies and potential precision oncology targets for patients. abstractsonline.com/pp8/#!/2โ€ฆ
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Want more control over your PSC cell populations for downstream differentiation? ๐Ÿ“ Take note of our new protocol and learn how to prepare single cells for use in intestinal #organoid differentiations: bit.ly/43BeQm4
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Cancer ball, OVCAR-3 cell line Forms loose aggregates in 3D culture rather than compact spheroids like the OVCAR-8 cell line Two different ovarian cancer cell lines, variances
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Bi/ond's technology ๐ž๐ง๐š๐›๐ฅ๐ž๐ฌ ๐ซ๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก๐ž๐ซ๐ฌ to study complex 3D tissues, organoids, ex vivo, spheroids, ... in vitro, which can provide more ๐š๐œ๐œ๐ฎ๐ซ๐š๐ญ๐ž & ๐ฉ๐ซ๐ž๐๐ข๐œ๐ญ๐ข๐ฏ๐ž ๐ซ๐ž๐ฌ๐ฎ๐ฅ๐ญ๐ฌ ๐ญ๐ก๐š๐ง ๐ญ๐ซ๐š๐๐ข๐ญ๐ข๐จ๐ง๐š๐ฅ ๐ฉ๐ซ๐ž๐œ๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐ฆ๐จ๐๐ž๐ฅ๐ฌ.
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Extracellular electrophysiology on clonal human beta-cell spheroids biorxiv.org/cgi/content/shorโ€ฆ #bioRxiv
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๐Ÿฅผ A research team from @CRGenomica explores the physical, biochemical, and genomic differences between #BreastCancer cells ๐Ÿงซ cultured in 2D and as 3D #spheroids. ๐Ÿ˜Ž Check it out in @embojournal! bit.ly/3vAY89T
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Exciting news from the #BSP2024! Our very own PhD student @AisteVit discussed a pioneering in vitro platform using HepG2 spheroids to culture F. hepatica parasites. This cutting-edge technique opens new doors for exploring host-pathogen interactions more closely than ever before!
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Molecular & physical differences of #breastcancer cells grown in 2D vs 3D: #spheroids have eg. more compact chromatin & distinct downregulated #genes. Image & research by Julieta Ramirez Cuellar, Roberto Ferrari et al @gpvicent @_BIST in @embojournal. On bpod.org.uk/archive/2024/4/6
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NEW SPECIAL FEATURE: Find the latest developments in 3D #cellculture, including 3D imaging of spheroids, cell magnetization, and characterization of 3D neuronal networks, plus much more! bit.ly/2Ur3bG7 @moldev @PromoCell_GmbH @GreinerBioOneUK @Corning
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Join us Friday for our webinar "Visualizing the Benefits of 3D Cell Culture," sponsored by @Corning Our guests will share their experiences with 3D cell cultureโ€”from the development of tissue specific spheroids to new imaging modalities. Register now: ow.ly/Wirf50Gy3gM
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New 'behind the technique' video up on BioTechniques now! This one looks at 3D cell culture with @Corning Life Science's Richard Eglen. What's the difference between spheroids and organoids? How are they being used across different fields? Find out now!

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Registration and abstract submission are OPEN for the Midwest Zebrafish Meeting 2024! Come network at this amazing regional meeting ๐ŸŸ๐Ÿ”ฌ๐Ÿงฌ๐Ÿงช Students, postdocs, and junior faculty โ€“ submit an abstract and present your research! tinyurl.com/MZFM2024
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