@CellSignal
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CST is a private, family-owned company, founded by scientists and dedicated to providing high-quality research tools.
Danvers, MA
Joined March 2009
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EMT is an example of phenotypic plasticity driven by dedifferentiation that can facilitate cancer progression
Use CST® IHC-validated antibodies against E-Cadherin and N-Cadherin to determine if the cadherin switch has been activated in your cancer model
hubs.ly/Q042ylQd0
An Open Letter Concerning Antibody Data Integrity - Open Letter to the Scientific Community | CST Commitment to Data Integrity
hubs.ly/Q04y7J6X0
Why We Have 13,500 Antibodies, Not >100K | Manufacturing Transparency
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Understanding how autophagy is contributing to the progression of a tumor is another aspect of Deregulating Cellular Metabolism ⚛️
CST® antibodies against key autophagy targets like LC3A/B, as well as antibody sampler kits, support researchers studying the rewiring of metabolic pathways within cancer cells: cellsignal.com/research/canc…
New Webinar Series: Master core lab techniques with CST experts
● Oct 1 – ELISA
● Oct 29 – IHC/IF
● Dec 3 – Flow Cytometry
● Jan 21 – Western Blotting
Register today: hubs.ly/Q04x76_R0
⚡🔬Planning your next experiment to examine cancer metabolism? Start with the pathways tumors most commonly hijack.
🔗 Explore key metabolic signaling targets, pathways, and antibody tools for Deregulating Cellular Metabolism on the #CSTBlog.
hubs.ly/Q04g4MRb0
Expectation: Cancer cells undergo cell death.
Observation: Cancer cells survive.
Why is that? Learn whether Bcl-2 family members are contributing to cell death resistance with antibody sampler kits from CST: hubs.ly/Q042yl7K0
A versatile, no-wash assay that’s amenable to high‑throughput, automated drug discovery workflows? That’s TR-FRET in action.
Learn how to configure Eu‑based TR‑FRET assays across your discovery pipeline in the latest #CSTblog
hubs.ly/Q04whpmV0
Determining whether the DNA homologous repair pathway is functioning or not is important, since that knowledge can be used in the treatment of BRCA1/2 cancers 🛠️
Use CST® Rad51 antibodies to identify Rad51 foci, a key indicator of an active HR pathway: hubs.ly/Q042ymzk0
In the latest #CSTBlog, we cover how to turn visually stunning multiplex images into robust spatial data—no closed system required.
Learn how to use QuPath and SignalStar Multiplex IHC to get cell‑level data for downstream spatial analysis👇
hubs.ly/Q04tyH0c0
Understanding how the SASP complex changes over time in the TME requires looking at key markers from many signaling pathways 🧐
Use IHC- and WB-validated antibodies to identify SASP associated proteins: hubs.ly/Q042ykF-0
Our Drosophila spike-in controls normalize CUT&RUN and CUT&Tag data, making it easier to identify global changes in histone marks between treated and untreated samples
See how whole‑workflow normalization turns “looks promising” into “I trust this result”
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Your development pipeline has enough uncertainty. Your antibodies shouldn’t add to it.
You can count on CST® reagents for their specificity, lot-to-lot consistency, and dependable supply chain that keeps your projects moving forward.
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Identifying new angiogenic targets and understanding mechanisms to therapeutic resistance are key in uncovering new vulnerabilities in tumor angiogenesis 🩸
Our IHC- and WB-validated antibodies support cancer discovery researchers in their quest to understand tumor vascularization:
cellsignal.com/research/canc…
Not every spatial experiment needs 20+ markers. The latest #CSTblog covers three considerations for choosing mid‑plex over high‑plex panels—data handling, experimental power, and panel flexibility in spatial biology workflows 👇
hubs.ly/Q04r8D1z0
🧬🔬 Designing an experiment to probe how cells respond to DNA damage or replication stress? Start with the DNA damage and repair pathways most often disrupted in cancer.
👉 Explore key signaling pathways and antibodies for Genome Instability & Mutation.
hubs.ly/Q04g4QWC0
🔬💀 Planning experiments to interrogate how tumors resist apoptosis in your model system?
👉 Explore pathway diagrams and IHC‑validated antibodies for studying the Cancer Hallmark: Resisting Cell Death on the #CSTBlog. hubs.ly/Q04fFXPJ0
Simplify chromatin profiling normalization with Drosophila spike-in controls from CST.
✅ Ready-to-use Drosophila spike-in controls for CUT&RUN/CUT&Tag normalization
✅ Whole-workflow assay coverage from cell handling through NGS
✅ Straightforward protocols with instructions for calculating the normalization factor
Reduce complexity and focus on the biology, not the method 👇
blog.cellsignal.com/chromati…