@TurveyLab

Dr. Stuart Turvey and the Turvey lab are commited to improving child health through research. Our research transforms lives. There is urgency to what we do!

 UBC and BCCH, Vancouver,Canada
turveylab.com/
Joined February 2017
  • Tweets2K
  • Following646
  • Followers1.4K
114Media
In this review, Mattison P. Stojcic et al. @TurveyLab comprehensively discuss known inborn errors of IRFs and how they contribute to our understanding of human biology. hubs.la/Q04B0P6r0 📘 From our #Cytokines collection: hubs.la/Q04B0P090 #Cytokines2026
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Turvey lab retweeted
Casanova Lab@casanova_labOct 9
The natural history of a peculiar IEI: IRF4 p.T95R combined immunodeficiency: Clinical features and transplant outcomes rupress.org/jhi/article/2/6/…

IRF4 p.T95R combined immunodeficiency: Clinical features and transplant outcomes

This study provides the first comprehensive description of the clinical phenotype and outcomes of all known patients with the heterozygous IRF4 p.T95R vari

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Access to #NewbornScreening for SCID is not yet universal around the world. This month, let’s continue to raise awareness, champion early diagnosis, and advocate for #SCID newborn screening for every baby, everywhere. #ScreenEveryBaby. Save lives. Change futures.
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Replying to @jhumimmunity @anne_puel @casanova_lab @BeziatV
(2/2) News & Views highlights two studies by Andersen et al. (rupress.org/jhi/article/2/3/…), and @turveylab (rupress.org/jhi/article/2/4/…)

Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-...

Here, Andersen and colleagues describe a patient with asthma, pulmonary aspergillosis, and elevated IgE homozygous for a deleterious variant in the oncosta

rupress.org
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Did you know there are more than 550 identified Primary Immunodeficiencies? 🤯 And researchers continue to discover more. Awareness leads to earlier diagnosis, and earlier diagnosis can save lives. 💙
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Our July issue is here! hubs.la/Q04ndpyG0 This cover highlights the first human biallelic OSMR deficiency. @TurveyLab et al. show that OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04ndtgx0
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.@jhumimmunity July issue: hubs.la/Q04ndF0D0 This cover highlights the first human biallelic OSMR deficiency. @TurveyLab et al. show that OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE hubs.la/Q04ndBrH0
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CHILD research out of @TurveyLab published in @NatureComms reveal that certain gut fungi 🍄 play a key role in the development of the immune system & in the development in kids of allergic asthma & some allergies. More: childcohort.ca/gut-fungi-key…
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Gut Fungi are Linked to Asthma Development | "Hundreds of millions of children worldwide are affected by allergic diseases, and the number is growing," said Dr. Stuart Turvey buff.ly/MH0aR72

Gut Fungi are Linked to Asthma Development | Microbiology

New research studies reported in Nature Communications have highlighted the importance of fungi in the gut microbiome, a community of microorganisms... | Microbiology

labroots.com
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Turvey lab retweeted
CIHR
@CIHR_IRSCJun 3
👩‍⚕️Are you an MD? Maintain your medical certification by peer reviewing for CIHR! Learn more: cihr-irsc.gc.ca/e/53995.html…
Earn CPD credits with CIHR peer review

ALT Earn CPD credits with CIHR peer review

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Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…

Human germline biallelic loss-of-function OSMR variants cause severe allergic disease

Samra, Sharma, et al. identify biallelic loss-of-function variants in OSMR as the cause of a new human primary atopic disorder characterized by severe earl

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هكذا يتراكم العلم؛ ملاحظة تقود لاكتشاف، واكتشاف يفتح بابا لفهم أعمق. قبل سنة تقريبًا، وصفنا جين ال OSM كسبب جديد لفشل نخاع العظم، واليوم دراسة جديدة توضح أن نقص المستقبل المرتبط فيه OSMR deficiency يسبب أمراض حساسية شديدة ومبكرة. المثير للاهتمام أن الدراسة تلمّح لفكرة مهمة,غياب الجين نفسه يؤثر على تكوّن ووظيفة نخاع العظم، بينما غياب المستقبل يعطّل إشارات مناعية والتهابية مرتبطة بالجلد والحساسية. هذا مثال جميل على كيف أن نفس المسار الحيوي ممكن يرتبط بأمراض مختلفة تمامًا حسب موقع الخلل فيه.
د. عبدالله الفلاح
@Abdullah_Med23 May 2025
تم التعرف على جين جديد يُسمى OSM مرتبط بحالات فشل نخاع العظم الوراثي، وذلك من خلال عمل بحثي شاركت فيه مع فريق علمي، ونُشر في مجلة The Journal of Clinical Investigation هذا العمل بدأ كحالة تحليل سلبي للاكزوم ، لكن من خلال إعادة قراءة التحليل الدقيقة، تمكنا من اكتشاف طفرة تؤدي الى فقدان وظيفة جين ال OSM في عائلتين غير مرتبطتين. تُظهر النتائج أن الطفرات في هذا الجين قد تؤثر على تكوين خلايا الدم، كما أظهرت الدراسة استجابة إيجابية للعلاج بدواء إلتْرومبوباغ/eltrombopag، مما يشير إلى إمكانية استخدامه كخيار بديل عن زراعة نخاع العظم في بعض الحالات. هذا الاكتشاف يعزز فهمنا لدور جين OSM في أمراض الدم الوراثية، ويفتح آفاقاً جديدة للتشخيص والعلاج. فخور بهذا الإنجاز العلمي الذي انتقل من الملاحظة إلى النشر.
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Turvey lab retweeted
Casanova Lab@casanova_labMar 4
A new human inborn error of immunity: OSMR deficiency can underlie the HIES Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome rupress.org/jhi/article/2/3/…

Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-...

Here, Andersen and colleagues describe a patient with asthma, pulmonary aspergillosis, and elevated IgE homozygous for a deleterious variant in the oncosta

rupress.org
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Turvey lab retweeted
Casanova Lab@casanova_labMay 29
A surprising and exciting observation ! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…

Human germline biallelic loss-of-function OSMR variants cause severe allergic disease

Samra, Sharma, et al. identify biallelic loss-of-function variants in OSMR as the cause of a new human primary atopic disorder characterized by severe earl

rupress.org
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New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs
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Instead of studying asthma only after children get sick, Dr. Stuart Turvey and his team at @UBC have taken a different approach. 💩 By analyzing infant stool samples, researchers found differences in gut bacteria that were associated with later development of #asthma: bit.ly/4rqPbHa
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Monogenic disorders of the IRF transcription factors. Review by Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey: hubs.la/Q046V_810 📘 In our #InnateImmunity collection: hubs.la/Q046VVBm0 #KSInnateImmune26
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New CHILD research in @CellReports by Darlene Dai, Charisse Petersen, @TurveyLab et al. suggests #breastfeeding 🤱may reduce socioeconomic-based differences in children’s chronic disease risk by influencing the infant gut #microbiome 💩@BCCHresearch More: childcohort.ca/ses-breastfee…
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New review: Allergy can be a genetic disease. Modi et al. show how primary atopic disorders reveal mechanisms controlling barrier integrity, immune signaling and tolerance, and inform precision therapies. From @turveylab: hubs.la/Q04fQSwn0 #Atopy #Therapeutics
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Turvey lab retweeted
Casanova Lab@casanova_labMay 7
Who would have thought 30 yrs ago that there would be > 50 inborn errors of immunity underlying atopy ? This has been the most insightful study of allergy: Primary atopic disorders: Monogenic insights into immunity rupress.org/jhi/article/2/4/…

Primary atopic disorders: Monogenic insights into immunity

Modi et al. review how primary atopic disorders, a group of monogenic inborn errors of immunity, reveal fundamental mechanisms regulating allergic inflamma

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