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U.S. stocks closed mixed Monday: S&P 500 +0.4%, Nasdaq +1.1%, Dow -0.1%.
AI shares drove the rebound after last week's selloff, but most stocks outside tech fell and the 10-year Treasury yield rose to 5.14% - a narrow bounce with rates still pressuring valuations.
EyePoint said its 475-patient Phase 3 LUCIA trial of DURAVYU in wet AMD missed non-inferiority versus aflibercept, echoing August's LUGANO miss.
It will end both wet-AMD trials early and cut about 53% of staff, targeting $30M in annual savings.
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Disc Medicine said bitopertin met both co-primary endpoints in Phase 3 APOLLO for EPP: blood PPIX fell 41.4% vs placebo and monthly pain-free light exposure rose 12.2 hours.
The FDA had requested APOLLO data after its February CRL; Disc plans an NDA resubmission by year-end.
U.S. homebuilder confidence fell to 29 in October from 32, below 31 consensus and its lowest since June 2012.
Buyer traffic dropped to 18; 43% of builders cut prices. NAHB cited 7%-plus mortgage rates, higher construction costs and weaker consumer confidence.
China's Q3 GDP grew 4.5% YoY, up from 4.3% in Q2 and above 4.4% consensus.
September factory output rose 5.5%, but retail sales gained just 1.1% and Jan-Sep fixed-asset investment fell 7.2% - a two-speed mix for CNH, commodities and China-linked equities.
Euro-area inflation was confirmed at 3.8% YoY in September, up from 3.2% in August; core held at 2.5%.
Energy added 1.71 percentage points to the headline rate, keeping ECB policy expectations and euro-area yields sensitive to incoming price data.
