Analyzing the complex relationships among immune cells with mathematical tools, @UniklinikBonn @ImmunoSens @HCM_Bonn @IEO_Bonn
Bonn, Germany
Joined March 2021
- Tweets29
- Following99
- Followers150
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Kevin Thurley retweeted
A new study shows how math can reveal hidden cancer cell strategies. By using a math model, researchers found that DNA-damaged cells often skip division and undergo polyploidisation—a survival response missed by observation alone.
doi.org/10.1101/2025.08.14.6…
Kevin Thurley retweeted
Researchers at #CharitéBerlin, @drfz_Berlin and @MDC_Berlin have identified the immune cells that cause severe kidney inflammation in #lupus. The study, published in @nature, could pave the way for future antibody therapies.
charite.de/en/service/press_…
ALT Kidney tissue (lupus mouse model) showing signs of incipient fibrosis (green). When the NKp46 receptor of the ILCs is blocked, the lupus nephritis recedes. Blue: cell nuclei. © Charité | Frauke Schreiber
Excited to share our analysis of cytokine communication using a new 4D simulation environment. Without spatial inhomogeneities, cytokine signals are basically ineffective! The spatial distribution depends on receptor feedback and tissue architecture. cell.com/iscience/fulltext/S…
Kevin Thurley retweeted
.@naturemethods has increasingly focused its attention on methods development in immunology and presents a special issue that highlights methods and technologies that have galvanized immunological research.
Editorial: go.nature.com/3VckKr2
Issue: go.nature.com/3ypwqxJ
ALT The image features a quote on a dual-tone background, with the top half in white and the bottom half in orange. The quote reads: “We are optimistic about the future of immunology and are eagerly watching this space for methods developments that will address open questions in this field.” Below the quote, the logo for "nature methods" is displayed in white text on the orange background.
Kevin Thurley retweeted
Glad to share work led by @Sarthak_Sahoo_ showing an increased prevalence of hybrid E/M state and higher heterogeneity in basal breast cancer, now out in @iScience_CP. Grateful to our collaborators @c_chaffer @JSomarelli & Jyothi S Prabhu @StJohnsResearch.
sciencedirect.com/science/ar…
Kevin Thurley retweeted
European Society for Spatial Biology (ESSB) is here, finally! ESSB is a recently founded scientific society dedicated to advancing research in the emerging interdisciplinary field of spatial biology. This is the perfect spot for spatial enthusiasts! Come join us!
Kevin Thurley retweeted
Collaborative work with the Yoshitane group!
Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells pnas.org/doi/full/10.1073/pn…
Kevin Thurley retweeted
The immune system is a uniquely dynamic environment. In a Comment, @mathematista discusses how custom-built mathematical models should complement experimental approaches to make immune kinetics more predictable.
nature.com/articles/s41592-0…
Kevin Thurley retweeted
Plz RT @biopatrika @IndiaBioscience @DynamicsLiving @physics_living @SMBMathOnco @GibinPowathil @vj_rajagopal @asharmaiisc @BalashaLab @DNagrathLab @pearce_maths @molab_uclm @jishnu1729 @rrockne @lab_craig @ThurleyLab @umichkim @sidharthagoyal @MathCancer @mathoncbro @DagmarIber
Exciting opportunity alert: Applications are now open for the Assistant Professor position in the Department of Bioengineering, IISc. If you're passionate about research and teaching in this field, we want to hear from you! Apply now! iisc.ac.in/careers/faculty-r… @iiscbangalore
Kevin Thurley retweeted
Our paper @ImmunityCP reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n
Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: authors.elsevier.com/c/1j0dm…
Kevin Thurley retweeted
Glad to share our mini-review on role of computational models in understanding T-helper cell plasticity, led by @PradyumnaVH @TheAviatorFrame @BE_IISc
sciencedirect.com/science/ar…
@Systems_Immunol @hongtian162 @ThurleyLab @bhanwar_p @smb_imin @Annaerial @sidjhun @biopatrika @InSDB_79
Kevin Thurley retweeted
#SimuCell3D is now out in @NatComputSci doi.org/10.1038/s43588-024-0… -
Massive thx to the editor Fernando Chirigati @fchirigati for handling our manuscript so well!!
The source code is available free online:
git.bsse.ethz.ch/iber/Public…
Can't wait to see it used!! #openscience
Kevin Thurley retweeted
Enjoying the company of colleagues and friends @teichlab @BockLab Kevin Thurley, Jonathan Badger @BanffNP while attending the fantastic #KSSystemsImmune24
keystonesymposia.org/confere…
Kevin Thurley retweeted
Congrats to @egbawden & Thomas Gebhardt to this amazing work on #melanoma #immunity. Fantastic collaboration within @BonnMelbPhD. Thanks to @dfg_public @UniMelb @UniBonn
Kevin Thurley retweeted
Absolutely thrilled to see our immune repertoire review out this week: fantastic collaboration with @mariottienca @vanessajmh @HabibBashour @KhangLeQuy @puneet021192!
New this week: Adaptive immune receptor repertoire (AIRR) analysis
@mariottienca @UiO_LifeSci @UniOslo_MED @victorgreiff outline the approaches and challenges in AIRR analysis and present future developments toward predicting adaptive immune responses.
go.nature.com/3U9qOAH
Kevin Thurley retweeted
Location matters! An epithelial cell’s position within a population determines its response to interferons through cell polarization & basolateral localization of the #interferon receptor ➡️ embopress.org/doi/full/10.10… @BoulantLab @Megan_Stanifer @UFMedicine #cellheterogeneity
Great to see the work of my first PhD student finally published in @ScienceAdvances, extending our data-based modeling framework to study a network of proliferating cell populations in chronic inflammation.
@DRFZ_Berlin @IEO_Bonn @ImmunoSens @HCM_Bonn
science.org/doi/10.1126/scia…
