New Ventures @ForesiteLabs applying emerging technology to biotech and therapeutics. Former @NSFGRFP fellow studying cancer & signaling dynamics @JohnsHopkins
Baltimore, MD
Joined March 2015
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Tim Aikin retweeted
1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia
science.org/doi/10.1126/scie… 🦠🧬🛠️🖥️💥
Tim Aikin retweeted
Thrilled to share my lab’s new preprint describing our discovery of the E2 ubiquitin conjugating enzyme UBE2H as a widely-shared dependency in aneuploid cancer cells. @biorxivpreprint @biorxiv_cancer
Tim Aikin retweeted
Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/S0092…
Tim Aikin retweeted
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tom_golde 🙌 @IBECBarcelona biorxiv.org/content/10.1101/…
Tim Aikin retweeted
❄️Time-deterministic cryo-optical microscopy, developed by researchers at @UOsaka_en, Janelia & collaborating institutions, rapidly freezes live cells under an optical microscope, capturing a snapshot of cellular activity in high resolution.
[Research] Freeze-framing the cellular world to capture a fleeting moment of cellular activity dlvr.it/TMgKNV #UOsaka #research
Tim Aikin retweeted
I'm often asked how human genetics can be used to validate drug targets.
In our new @NatureCVR paper, we provide an end-to-end framework for IL-6 inhibition🧵
👉build a genetic proxy
👉demonstrate potential for cardiovascular benefit
👉assess expected & unexpected safety signals
Tim Aikin retweeted
3D cross-sectional views of the dynamics of chromosomes (H2B, blue) and the endoplasmic reticulum (orange) in interphase and mitotic LLC-PK1 cells over a 50 x 180 um field at 6 sec intervals, as seen in the lattice light sheet structured illumination mode of MOSAIC.
Tim Aikin retweeted
What does pushing the boundaries of model capacity and data scale do for generative protein language models? I’m super excited to share our latest work @ProfluentBio where we begin to explore and test some of our hypotheses!
Tim Aikin retweeted
Astonishing breakthrough in #organoid engineering, as reported in @Nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and colleagues: intestinal epithelial organoids incorporating tissue-resident immune cells. @IHB_Research @Roche go.roche.com/4a5t1
Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research nature.com/articles/s41586-0…
Tim Aikin retweeted
Protein design for ...checks notes... growing semiconductors (!!)
Biology is nanotechnology.
Tim Aikin retweeted
We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/S0092…
Tim Aikin retweeted
We are delighted to share our work, now available in
@Nature:
nature.com/articles/s41586-0…
Our scoring system can be accessed here: kinase-library.phosphosite.o…
Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features!
#TheKinaseLibrary #KL
Tim Aikin retweeted
We are delighted to share the #tyrosine @KinaseLibrary, now in @Nature: nature.com/articles/s41586-0…
Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.o…
#TheKinaseLibrary #KL #part2
🧵
1/9
Tim Aikin retweeted
Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible.
If you are interested in the mechanisms behind stress induced endocycling or the role of CDK4/6 in maintaining G2 arrest, check it out:
science.org/doi/10.1126/scie…
Tim Aikin retweeted
We joined forces with ARCH Venture Partners /
@rtnarch to incubate @xaira_thera, a biotech company using AI to re-engineer the entire drug discovery and development process. Read more: endpts.com/in-biggest-ever-b…
Tim Aikin retweeted
new results! We describe an optogenetic method to 'paint' patterns of morphogen signals in zebrafish embryos to guide their development. Preprint here:
biorxiv.org/content/10.1101/…
Check out @LordLab_Pitt's explainer thread for the details!
We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development.
biorxiv.org/content/10.1101/…
Tim Aikin retweeted
Capturing the axial elongation of a zebrafish embryo (back and forth) using our single objective LSM DaXi #FluorescenceFriday #zebrahub #zebrafish 🐟🔬
Tim Aikin retweeted
In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to self-organize embryonic stem cells into spatially-ordered embryonic patterns. biorxiv.org/content/10.1101/… #crispr
Tim Aikin retweeted
2/ #FluorescenceFriday #cellbiology #bioart
Dictyostelia start out as unicellular amoeba, but eventually many amoebae come together to form a multicellular slug and, eventually, a fruiting body to complete its life cycle. The initial stages of aggregation are shown here in 3D at 6 volumes/min over 48 min by lattice light sheet microscopy.
doi.org/10.1126/science.1257…
Tim Aikin retweeted
@TheDynamicTim and @AdlerGuerrero work is out in Developmental Cell! You guys are amazing.
If you are interested in how oncogenes can prime cells for whole genome doubling take a look!
authors.elsevier.com/a/1iy3F…