@RegotLab

Developing biosensors to study signaling dynamics and cell fate during collective cell behavior

 Baltimore, MD
RegotLab.com
Joined April 2019
  • Tweets150
  • Following324
  • Followers697
18Media
The @RegotLab is searching for talented #postdocs! If you or someone you know is interested in #SignalingDynamics please apply and share #postdocjobs #Hiring #Biology #PhD #AcademicTwitter
Job add for a postdoc in the Regot Lab at Johns Hopkins. Contact sregot@jhmi.edu for information.

ALT Job add for a postdoc in the Regot Lab at Johns Hopkins. Contact [email protected] for information.

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Postdoctoral position available! We're looking for a creative scientist interested in signaling-mediated control of cell cycle transitions. If you're excited by single molecule imaging, live cell biosensors, and fundamental molecular mechanisms, we'd love to hear from you.
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🌐 regotlab.com Please RT/share! #Postdoc #CellBiology #SingleMolecule #LiveCellImaging #QuantitativeBiology #Microscopy
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I’m happy to share that I’ve been selected as a 2025 HHMI Gilliam Fellow. This fellowship will support my PhD research at Johns Hopkins, where I study whole-genome doubling in tumor evolution. hhmi.org/programs/gilliam-fe…
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Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible. If you are interested in the mechanisms behind stress induced endocycling or the role of CDK4/6 in maintaining G2 arrest, check it out: science.org/doi/10.1126/scie…

CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication

Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis (S) phase transition of the cell cycle by...

science.org
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Sergi Regot retweeted
Tianchi Xin@TerenceXin
30 Apr 2024
Excited to share my latest research work just published online today in @NatureCellBio! We find oncogenic Kras mutation induces abnormal tissue architecture through converting pulsatile into sustained ERK signal activation. @nyscf @YaleGenetics rb.gy/nezris
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Sergi Regot retweeted
Tianchi Xin@TerenceXin
30 Apr 2024
Replying to @TerenceXin @NatureCellBio @nyscf @YaleGenetics
I am very grateful to all the co-authors, especially my incredible mentor Valentina Greco @valentatormenta, our wonderful collaborators Sergi Regot @RegotLab, Hironobu Fujiwara @HiroFujiwara and H. Amalia Pasolli @APasolli.
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Sergi Regot retweeted
FASEB
@FASEBorg
23 Apr 2024
Cell signaling investigators, submit your cutting-edge research by May 12! @albecklab, @Mia__Sung, @steve_cappell, and @schmittwitt_ are looking forward to featuring you at #DECSRC for a short talk or poster session. View the details and save your space: hubs.ly/Q02tN76k0
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Travel award deadline for #InSiDE FASEB is April 30th! Apply now! events.faseb.org/event/595dd…
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Congrats to our amazing graduate student Connor Mckenney on his recent poster presentation at the Conceptual power of single cell biology conference!!
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Why are senescent cells irreversibly arrested in the cell cycle? Today in @CellReports we report in a study led by talented postdoc @Afifi_MM that the transcription factor MYC is constantly degraded, keeping the cells locked in a non-proliferative state. cell.com/cell-reports/fullte…

Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

Afifi et al. use time-lapse imaging, high-throughput single-cell analyses, and quantitative measurements to investigate the irreversibility of cellular senescence. Senescent cells enter and maintain...

cell.com
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Congrats to our great graduate student @AdlerGuerrero on presenting his poster/talk on how sustained ERK signaling leads to whole genome doubling through mitotic bypass at the Gordon Research Conference for Cell Growth and Proliferation.
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Congrats to our great graduate student Connor Mckenney on winning the @JohnsHopkinsMBG Journal Club Award this year!! 📖🧬
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Congrats to our great post-doc @VDunlock for presenting her poster on mechanisms of kinetic proofreading in T cells at the FASEB conference!
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A book in genetics for kids. What’s wrong with this picture?
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Enjoying my sabbatical from #uicbarcelona with Sergi Regot at @RegotLab in Baltimore.
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Really cool new report in @CellSystemsCP by @RegotLab and @amyfpeterson from @JohnsHopkinsMBG. sciencedirect.com/science/ar… Since the cool thing these days with #peerreview is to experiment, my first-round review of the paper is also published and linked in the 🧵below
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Amy’s paper is out in Cell Systems! authors.elsevier.com/a/1g38-…
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Sergi Regot retweeted
Bin Wu Lab@binwu1
9 Nov 2022
Excited to share our preprint about "Bursting Translation on Single mRNAs in Live Cells" biorxiv.org/content/10.1101/… by Nathan Livingston @nliving93 and Jiwoong Kwon, in collaboration with @JianLiu_Lab, @GreenLabJHMI and @taekjip
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Sergi Regot retweeted
Seydoux Lab@Seydouxlab
9 Nov 2022
Are all phase-separated compartments functional, or are some “accidental condensates”? Check out our new preprint with @PAskjaer to find out more: biorxiv.org/content/10.1101/…

Cytoplasmic nucleoporin foci are stress-sensitive, non-essential condensates in C. elegans

Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier that separates nucleoplasm from cytoplasm. Nups have also been observed in cytoplasmic foci proposed to function as pore...

biorxiv.org
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Sergi Regot retweeted
Tianchi Xin@TerenceXin
19 Sep 2022
Excited to share the preprint of my latest work. Wonder how oncogenic Kras disrupts tissue architecture? We find it does so through converting pulsatile into sustained ERK activation! Thank my mentor @valentatormenta, collaborator @RegotLab and other authors!
bioRxiv@biorxivpreprint
17 Sep 2022
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation biorxiv.org/cgi/content/shor… #bioRxiv
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