@TheColonnaLab

We study innate immunity with a focus on ILCs, macrophages, and DCs. The account is led by trainees. @wusm_pathology @WUSTLmed

 St. Louis, MO
sites.wustl.edu/colonnalab
Joined April 2021
  • Tweets105
  • Following118
  • Followers4K
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The Colonna Lab retweeted
Julia Belk
@juliabelkAug 14
The transcription factor MAF is known from human genetics to be important in Alzheimer’s disease, but its precise function within the brain has been unclear. Our latest, out today in @CellCellPress, dissects the role of MAF in brain macrophages. 1/ cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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The Colonna Lab retweeted
Julia Belk
@juliabelkJul 30
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/ nature.com/articles/s41586-0…

Somatic mutations reveal the ontogeny of microglia in human ageing

Nature - A widespread influx of myeloid cells into the healthy human brain contributes to the pool of human microglia and becomes common with ageing.

nature.com
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The Colonna Lab retweeted
Immunity@ImmunityCPApr 29
Online now: Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer dlvr.it/TSHW39

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset...

Ulezko Antonova et al. examine plasmacytoid dendritic cells (pDCs) in lymphoid tissues from infancy to adulthood and identify a cycling population of pDCs in fetal and infant lymphoid organs that is...

cell.com
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The Colonna Lab retweeted
Science Magazine
@ScienceMagazineMar 5
Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science. 📄: scim.ag/3NjPIfP #SciencePerspective: scim.ag/4rgI1oL
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The Colonna Lab retweeted
Science Immunology@SciImmunologyMar 2
Platelet-derived growth factor D (#PDGFD) binds to PDGFRβ in #ILC3s in mice and NKp44 in human ILC3s, promoting divergent innate immune responses following intestinal infections. @TheColonnaLab Learn more in Science #Immunology: scim.ag/4aXJmL1
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The Colonna Lab retweeted
Immunity@ImmunityCPFeb 26
Online now: Immunity in Alzheimer’s disease: From mechanisms to therapies dlvr.it/TR9xxM

Immunity in Alzheimer’s disease: From mechanisms to therapies

Alzheimer’s disease (AD) is driven by dynamic interactions between innate and adaptive immunity. Colonna, Chen, and Holtzman review recent advances in the genetic and mechanistic understanding of how...

cell.com
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The Colonna Lab retweeted
Science Immunology@SciImmunologyJan 27
A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue
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The Colonna Lab retweeted
Siling Du@DuSiling26 Jun 2025
🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s41590-0…

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity

Nature Immunology - Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that...

nature.com
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The Colonna Lab retweeted
WashU@WashU30 Apr 2025
Congratulations to physicist Carl Bender of @washuartsci and immunologist Marco Colonna @washumedicine, who have been elected to the @americanacad for their pioneering work in quantum theory and immune pathways in Alzheimer’s. bit.ly/42SK87N
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The Colonna Lab retweeted
Shoutang WANG@ShoutangW13 Feb 2025
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control rupress.org/jem/article-abst…, in this work we linked autophagy with UPR and ferroptosis in the microglial response to AD @CaiZhangying @TheColonnaLab 🥳🍻🆗

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

Microglia contain Aβ plaques in Alzheimer’s disease (AD). In an AD mouse model, microglial Atg7 deletion impaired plaque coverage, increasing Aβ diffusion

rupress.org
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Cai et al. @TheColonnaLab @washumedicine show that, in an #Alzheimers mouse model, microglial Atg7 deletion impairs plaque coverage, increasing Aβ diffusion & neurotoxicity, linked to reduced UPR, increased oxidative stress, & #ferroptosis of #microglia hubs.la/Q036BHM10
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The Colonna Lab retweeted
José Fachi, PhD@zefachi12 Feb 2025
Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! @TheColonnaLab @VinoloM @pewtrusts #Microbiology #Immunology #CellHostMicrobe
Cell Host & Microbe@cellhostmicrobe12 Feb 2025
Our February issue is now live. Come explore the depths of microbiology! cell.com/cell-host-microbe/c…
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The Colonna Lab retweeted
Siling Du@DuSiling9 Aug 2024
🧵 Excited to share my first preprint from my PhD @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 biorxiv.org/content/10.1101/…

Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct...

Microglia are thought to originate exclusively from primitive macrophage progenitors in the yolk sac (YS) and to persist throughout life without much contribution from definitive hematopoiesis. Here,...

biorxiv.org
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The Colonna Lab retweeted
Xavier Lab@TheXavierLab28 Jun 2024
Collaboration with @TheColonnaLab & others, in press at @Dev_Cell: The FGFR1OP gene, implicated in #Crohns, contributes to intestinal barrier function by modulating the actin cytoskeleton in crypt cells. (1/2) cell.com/developmental-cell/…

The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

Trsan et al. show that deletion of the centrosomal protein FGFR1OP in mouse intestinal cells disrupts crypt architecture, impairs regeneration, and causes inflammation. FGFR1OP is crucial for...

cell.com
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The Colonna Lab retweeted
Jinchao Hou@JinchaoHou2290326 Apr 2024
Thrilled to share our work has been highlighted by Dr Monica M. Bertagolli @NIHDirector @TheColonnaLab
This Post is from an account that no longer exists. Learn more
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The Colonna Lab retweeted
Raki Sudan@RakiSudan3 Apr 2024
Excited to share our latest review describing Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation @TheColonnaLab - Immunological Reviews - Wiley Online Library onlinelibrary.wiley.com/doi/…

Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Group 1 innate lymphoid cells (ILCs), comprising ILC1s and natural killer cells (NK cells), belong to a large family of developmentally related innate lymphoid cells that lack rearranged antigen-sp...

onlinelibrary.wiley.com
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The Colonna Lab retweeted
IdoAmitLab@IdoAmitLab31 May 2023
Exciting talk from @TheColonnaLab on new therapeutic approaches targeting microglia receptors in AD #NIM2023
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The Colonna Lab retweeted
Yingyue Zhou@YingyueZhou21 May 2023
Colonna lab California sub-lab @TheColonnaLab
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Excited to share our new paper in @NatImmunol on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: rdcu.be/damS8
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The Colonna Lab retweeted
WUSTL Immunology@WUSTLImmuno17 Apr 2023
Gwen @GwenRandolph_ and Vincent @TheVincentPeng modeling WashU Immunology Program Jackets at #MyeloidCells @KeystoneSymp! @WUSTLImmuno @WUSTLdbbs
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