@TheBenSpikeLab

Working to understand how cells integrate cues to sustain complex tissues, how this goes awry in diseases like cancer, and how to put things right.

Joined April 2021
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Congrats to Ozlen, Brooke and the rest of the gang for getting this preprint up and the formal manuscript under peer review. biorxiv.org/content/10.1101/…

Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/St...

Breast cancers are categorized into subtypes with distinctive therapeutic vulnerabilities based on expression of clinically targetable receptors and other genes that mimic cell types of the normal...

biorxiv.org
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Spread the word! We have two Biostatistics faculty searches open @UofUHealth, in collaboration with @HuntsmanCancer. @UofUPHS #MedTwitter #AcademicTwitter #BlackInStats #PopulationHealth #HigherEdJobs #EpiJobs
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Today, we released Uncharted to transform cancer care and empower patients in a whole new way. An emotional day for me. Share with those you love: unchartedhealth.org/

Uncharted

Cancer Patients - get free, scientifically valid cancer education created by scientists, researchers, and oncologists to understand your cancer, take control of your life, and improve your outcome.

unchartedhealth.org
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Congrats @Freeman_DW @MariannKruithof on a very thought provoking review! mdpi.com/1279934
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Stoked to start work on a DOD-CDMRP-Breakthrough level 2 award trying to learn (and block) some mechanisms of adaptive plasticity in breast cancer with our partnering lab @BryanWelm !
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First Lab Tweet! Proud of our team. @Babbling8rooke @Freeman_DW @Elnaz_MM and Ozlen Balcioglu. Picking up some retro-accomplishments on this first one 😁. Brooke and David passing prelims. Yay! Also: breast-cancer-research.biome…

CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Breast Cancer Research - CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes...

link.springer.com
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and this: biorxiv.org/content/10.1101/…

Factorization-based Imputation of Expression in Single-cell Transciptomic Analysis (FIESTA)...

Motivation Single cell RNA sequencing (scRNA-seq) is a powerful gene expression profiling technique that is presently revolutionizing the study of complex cellular systems in the biological sciences....

biorxiv.org
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Inspiring day with the lab at the Y-Me softball tournament with survivors, donors and sponsors raising money for breast cancer research at the University of Chicago! So many strong women and their families and the irrespressible Ginger Rugai
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