@Freeman_DW

MD/PhD Student - University of Utah Graduate Student in the Spike Lab https://xitter.cf/t.co/xosZ7885cZ Views are my own. Retweets ≠ endorsement.

 Salt Lake City, UT
Joined May 2020
  • Tweets27
  • Following18
  • Followers14
2Media
This seems like an excellent example of "not all mouse findings translate to humans". nejm.org/doi/full/10.1056/NE…
Today, we released Uncharted to transform cancer care and empower patients in a whole new way. An emotional day for me. Share with those you love: unchartedhealth.org/

Uncharted

Cancer Patients - get free, scientifically valid cancer education created by scientists, researchers, and oncologists to understand your cancer, take control of your life, and improve your outcome.

unchartedhealth.org
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Happy to have this review on Cripto in #Cancer now out. Lots of exciting unknowns to still be worked out in the field. Great collaboration between @TheBenSpikeLab @Freeman_DW @euzoni @ellisyeahh @karkampouna @huntsmancancer mdpi.com/1422-0067/22/18/101…

Whence CRIPTO: The Reemergence of an Oncofetal Factor in ‘Wounds’ That Fail to Heal

There exists a set of factors termed oncofetal proteins that play key roles in ontogeny before they decline or disappear as the organism’s tissues achieve homeostasis, only to then re-emerge in...

mdpi.com
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First Lab Tweet! Proud of our team. @Babbling8rooke @Freeman_DW @Elnaz_MM and Ozlen Balcioglu. Picking up some retro-accomplishments on this first one 😁. Brooke and David passing prelims. Yay! Also: breast-cancer-research.biome…

CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Breast Cancer Research - CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes...

link.springer.com
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Looking at the vaccination rates in Utah by race there are still large gaps between different racial groups. Vaccine equity should be one of the foremost priorities as we continue to push later into the vaccination efforts. Data from: coronavirus.utah.gov/case-co… #PopHealthPath
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Interesting infographic from @nytimes comparing vaccination and rates and #COVID19 mortality. Even more reason to #GetVaccinated and ensure vaccines are widely available globally. #PopHealthPath nytimes.com/interactive/2021…

The Pandemic Has Split in Two (Published 2021)

Zero deaths in some cities. Thousands in others. The pandemic’s fault lines continue to widen as vaccines flow toward rich countries.

nytimes.com
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Exciting new population health program being established between @UofUHealth and @Intermountain #PopHealthPath hcinnovationgroup.com/popula…

Intermountain Partners With U. of Utah on Population Health Program

Health system investing $50 million to establish the University of Utah Intermountain Healthcare Population Health Student Scholars Program

hcinnovationgroup.com
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Triple-negative breast cancer has long been known to disproportionately affect African-American women compared to European-American women. Below is a great review highlighting the non-biologic and biologic components that are at play. #PopHealthPath pubmed.ncbi.nlm.nih.gov/3341…

Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-bio...

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor...

pubmed.ncbi.nlm.nih.gov
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Interesting talk last month @huntsmancancer from Gloria Coronado of @KPCHR focusing on identifying individuals unlikely to pursue follow-up colonoscopies following abnormal FIT tests. #PopHealthPath pubmed.ncbi.nlm.nih.gov/3317…

Development of a multivariable prediction model to identify patients unlikely to complete a...

This trial was registered at ClinicalTrials.gov ( NCT01742065 ) on December 5, 2012. The protocol is available.

pubmed.ncbi.nlm.nih.gov
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There has been a lot of attention within medical schools as to how COVID has negatively impacted student training. One positive that has come out is an increase in student volunteering and outreach at medical schools in Brazil. #PopHealthPath journals.plos.org/plosone/ar…

Medical students’ perceptions and motivations during the COVID-19 pandemic

Background There has been a rapid increase in the number of cases of COVID-19 in Latin America, Africa, Asia and many countries that have an insufficient number of physicians and other health care...

journals.plos.org
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#COVID19 has put a lot of basic research at the forefront of public attention. Maintaining the public's interest in pre-clinical work is important beyond COVID. Below is an interesting article that discusses ways to do that. #PopHealthPath journals.plos.org/plosone/ar…

Facilitating public and patient involvement in basic and preclinical health research

Involving patients in research broadens a researcher’s field of influence and may generate novel ideas. Preclinical research is integral to the progression of innovative healthcare. These are not...

journals.plos.org
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Regarding vaccine hesitancy, data from the UK suggests written vaccine information is more effective when focused on the personal benefits of getting vaccinated rather than discussing societal benefits #PopHealthPath #GetVaccinated #vaccinehesitancy thelancet.com/journals/lanpu…

Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the...

In the approximately 10% of the population who are strongly hesitant about COVID-19 vaccines, provision of information on personal benefit reduces hesitancy to a greater extent than information on...

thelancet.com
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Interesting analysis of census data confirms what many have argued for a long time, increased access to contraception increases high school graduation rates. advances.sciencemag.org/cont… #PopHealthPath
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100% this ⬇️
Michele K. Evans,M.D.@evansmkt7 Jan 2021
Capitol police officer who posed with insurrectionist should be fired #Disgraceful
Amidst the exciting news regarding the @pfizer #COVID19 #vaccine efficacy and safety, it only seems fitting that William #Shakespeare was one of the first recipients in the UK.
Excited to be a part of this work out of the #SpikeLab. Together, Cripto signaling and cellular stress promote plasticity and #stemness in #breastcancer. @huntsmancancer @UofUMedicine breast-cancer-research.biome…

CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Breast Cancer Research - CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes...

link.springer.com
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Timely work from @UUtah showing the effects of the winter inversion on the local homeless population. Even short periods of homelessness had major health implications in the context of air pollution. Clean air should be a medical priority. mdpi.com/1660-4601/17/22/841… #PopHealthPath
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Deciding how to delineate politics and medicine is no easy matter. However, providers have a responsibility to the entire population to disseminate scientific truths. Kudos to @NEJM for taking a stand. nejm.org/doi/full/10.1056/NE… #pophealthpath
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The slowdown in the Moderna #COVID19 #vaccine trial is a great example of why study design matters so much! Not including a representative number of minority groups undercuts the external validity of such clinical trials. reuters.com/article/us-healt… #PopHealthPath
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Fascinating research from a @UofUMedicine grad @KrisOlsonMDPhD looking at the real effects of 'less-lethal' forces. Disappointing that research like this is forced to be done after these weapons are already used widely. nejm.org/doi/full/10.1056/NE… #PopHealthPath
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